In the article, we will consider the instruction for eye drops "Ciprofloxacin".
This is an antibacterial drug with a wide range of effects and is included in the group of fluoroquinolones. Designed for topical use in the treatment of ENT and ophthalmic diseases. It can overwhelmingly affect the DNA gyrase of a pathogenic cell, disrupt DNA synthesis, cell growth, division. It provokes the occurrence of morphological changes and the subsequent rapid death of a pathogenic cell.
Drop Composition
Eye drops "Ciprofloxacin" have a dosage of 0.3%, externally they look like a transparent liquid with a yellowish tint or completely colorless.
The active component in the composition of the drug is represented by ciprofloxacin monohydrate hydrochloride. As auxiliary substances used: purified water, glacial acetic acid, benzalkonium chloride, disodium edetate dihydrate, mannitol, sodium acetate trihydrate.
Packaged in dropper bottles made of polymer material. Each bottle holds 5 ml of solution. Additionally packaged in a pack of cardboard.
Pharmacological effects of this drug
Eye drops “Ciprofloxacin” is an antibacterial drug with a wide spectrum of effects, it belongs to the group of fluoroquinolones. Designed for local use in the field of otolaryngology and ophthalmology.
The drug is able to overwhelmingly affect the DNA gyrase of a bacterial cell, disrupt DNA synthesis inside it, inhibit the division of a pathogenic cell, its growth.
It provokes a pronounced morphological change in the cell membranes, as a result of which the bacterial cell quickly dies.
The active component has a bactericidal effect on gram-negative pathogens during periods of their division and dormancy (since it is able to influence not only DNA gyrase, but also provoke lysis of the cell wall). Gram-positive bacteria - only during the period of their division.
The use of Ciprofloxacin eye drops does not cause the microorganism to acquire resistance to other antibiotic drugs that are not part of the gyrase inhibitor group. Thus, it is highly effective against bacteria that are resistant to tetracyclines, cephalosporins, penicillins, aminoglycosides and other antibiotics.
The drug shows its activity against gram-negative aerobes: Citrobacter spp., Enterobacter spp., Proteus vulgaris, Klebsiella spp., Shigella spp., Escherichia coli, Proteus mirabilis, Hafnia alvei, Serratia marcescens, Salmonella spp., Edwardsiella tresses, Salmonella spp., Edwardsiella tressi, ., Providencia spp., Vibrio spp., Morganella morganii, Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Campylobacter jejuni, Pasteurella multocida, Aeromonas spp., Plesiomonas shigelloides, Neisseria.
Also, the activity of the drug is observed in relation to gram-positive aerobes: Staphylococcus spp. (Staphylococcus saprophyticus, Staphylococcus hominis, Staphylococcus haemolyticus, Staphylococcus aureus), Streptococcus spp .; some intracellular pathogens: Mycobacterium tuberculosis, Legionella pneumophila, Chlamydia trachomatis, Brucella spp., Corynebacterium diphtheriae, Mycobacterium kansasii, Listeria monocytogenes.
Resistance to ciprofloxacin is possessed by: Clostridium difficile, Nocardia asteroids, Bacteroides fragilis, Pseudomonas maltophilia, Pseudomonas cepacia, Ureaplasma urealyticum, as well as many staphylococci that are resistant to methicillin.
The drug is not effective against treponema.
Resistance to ciprofloxacin develops rather slowly: after exposure to the active component, persistent microorganisms practically do not remain, but at the same time, bacterial cells do not contain enzymes that can inactivate it.
Indications for the use of the drug
Eye drops “Ciprofloxacin” are indicated for use in the field in ophthalmology if the patient has the following pathologies or conditions:
- Preoperative preparation for ophthalmological procedures.
- Postoperative preventive measures aimed at preventing the development of complications of an infectious nature.
- Lesions of the eyes of an infectious nature, provoked by injury or contact with a foreign body.
- Meibomite.
- Dacryocystitis in a chronic form.
- Corneal ulceration of bacterial origin.
- Keratoconjunctivitis.
- Keratitis
- Blepharoconjunctivitis.
- Blepharitis.
- Conjunctivitis in acute, subacute form.
Also, drops can be used in otorhinolaryngology with the goal of:
- Therapies for postoperative complications of infectious genesis.
- Therapy of the external form of otitis media.
Use of this medication
When using eye drops "Ciprofloxacin" it is recommended to adhere to the following dosages:
- For the treatment of moderate and mild infectious lesions, it is indicated to instill the medicine into the conjunctival sac of the affected eye every 4 hours in an amount of up to 2 drops. If the infection is severe, it is necessary to use 2 drops every hour. As soon as the patient's condition improves, the frequency of instillations and the dose should be reduced.
- In order to treat a ulcerative lesion of the cornea with bacterial origin, it is necessary to instill 1 drop every quarter hour for six hours. Then the frequency of instillations is reduced - the drug is used every half hour. From the second day of therapy, instillations are carried out every hour, in 3-14 days - every 4 hours.
If eye and ear drops “Ciprofloxacin” are prescribed for the treatment of ENT diseases, it is important to clean the external ear canal before use. The solution during use should have room temperature so that the stimulation of the vestibular apparatus does not occur.
Instillation should be carried out up to 4 times a day in an amount of up to 4 drops.
Recommendations for the use of the medication
After instillation of the drops, the patient needs to be on the opposite side for some time (up to 10 minutes).
In some cases, it is allowed to put a cotton swab dipped in the preparation into the cleaned ear canal. It is allowed to find a tampon in the ear until the next procedure.
Therapy for ear diseases can last up to 10 days, but treatment may be extended at the discretion of the doctor.
Negative effects from the use of the drug
Against the background of the use of Ciprofloxacin eye and ear drops, some negative reactions may develop:
- Corneal Infiltration.
- The appearance of spots on the cornea.
- Keratopathy
- Keratitis
- The appearance of crystalline white precipitate in patients suffering from corneal ulcers.
- Decreased vision.
- Unpleasant taste in the oral cavity immediately after using the drug.
- Sensation in the eyes of the presence of a foreign body.
- Lacrimation.
- Photophobia.
- Swelling of the century.
- Hyperemia and slight soreness in the tympanic membrane, the external part of the auditory canal.
- Burning.
- Itching
- The development of superinfection.
- Allergic reaction.
- Nausea.
If these adverse effects occur, it is important to consult a doctor.
Contraindications
“Ciprofloxacin” should not be prescribed in the following cases:
- Increased susceptibility to the ingredients of the drug.
- Age to a year.
- Viral keratitis.
The drug can be used to treat pregnant women and women in the lactation period, but only in cases where the doctor suggests that the benefits of using the drug will exceed the likely harm to the child.
Analogues of a drug
If necessary, Ciprofloxacin can be replaced by one of its analogues. The most popular are: Eleflox, Pefloxacin, Oflocid, Ofloxacin, Nolitsin, Moksimak, Levofloxacin, Levotek, Ivacin, Zanocin, Gatispan, Abaktal ”,“ Tseprova ”,“ Ecocifol ”,“ Cifran ”,“ Ciprodox ”,“ Ciprinol ”, eye drops“ Ciprofloxacin-AKOS ”,“ Procipro ”,“ Ciprofloxacin-Promed ”,“ Ifipro ”,“ Ciprofloxacin-FPO ”, Basigen, Ciprofloxacin-Teva.
Indications of the drug "Ciprofloxacin-AKOS"
The medication is prescribed for infectious and inflammatory diseases of the eye: acute and subacute conjunctivitis, keratoconjunctivitis, blepharoconjunctivitis, blepharitis, keratitis, bacterial corneal ulcer, chronic dacryocystitis, meibomite, infectious eye lesions. Drops are also effective for pre- and postoperative prevention of infectious complications in ophthalmic surgery.
Contraindicated in the presence of viral keratitis, in children under 1 year. A cautious reception is required in case of cerebral arteriosclerosis, cerebrovascular accident, convulsive syndrome.
Reviews on this drug
Patients respond to drops of "Ciprofloxacin" almost always positively. They have a high degree of effectiveness. Almost do not provoke undesirable effects. The therapeutic effect against the background of their use is manifested almost from the first days of use. The advantage of the drug is its availability and the possibility of use in the treatment of children.
Despite the many positive characteristics encountered, self-medication should not be. The drug should be prescribed only by a doctor after a full clinical examination.
We reviewed the instructions for use with Ciprofloxacin Eye Drops.