The medication “Ibuklin Junior” with ibuprofen is produced by the Indian pharmaceutical company Dr. Reddy's Laboratories and is an antipyretic and analgesic drug with anti-inflammatory effect. The cost of this medicine in Russian pharmacies is about 100 rubles per pack.
Composition and form of release
What is Ibuklin Junior with ibuprofen form of release? These are dispersible tablets: flat, round, pink in color with bright splashes, have a fruity mint smell, at risk and a chamfer on one side. Packed in tablets of 10 pieces in blisters. In a cardboard box contains 20, 2 or 1 blister.
The composition of one tablet contains active substances: ibuprofen - 100 mg, paracetamol - 125 mg. The following substances are used as auxiliary components in the production of tablets: corn starch, sodium carboxymethyl starch (type A), microcrystalline cellulose, aspartame, colloidal silicon dioxide, lactose, talc, flavorings, glycerol, peppermint leaf oil, magnesium stearate, dye.
pharmachologic effect
"Ibuklin Junior" with ibuprofen is a combined medication, the pharmacological properties of which are due to the action of its constituent elements. Paracetamol, as one of them, has analgesic and antipyretic effects, and in an indiscriminate way blocks cyclooxygenase (COX). Another element - ibuprofen - represents the category of non-steroidal anti-inflammatory drugs (NSAIDs), and also has antipyretic and analgesic properties. Its therapeutic effect is due to the suppression of COX-1 and COX-2 and a change in the metabolic processes of arachidonic acid, which reduces the concentration in the blood of prostaglandins (mediators of inflammation, pain and hyperthermia). In addition, this substance has an inhibitory effect on the proliferative and exudative phases of inflammation.
The combination of these active elements is most effective in comparison with monotherapy with one of them. This confirms the instructions for use for Ibuklin Junior with ibuprofen.
Pharmacokinetic characteristics
Paracetamol is characterized by high absorption. It binds to plasma proteins by more than 10%. The highest concentration of a substance in the blood is 5–20 μg / ml, and this level is reached in about 30–120 minutes. Paracetamol is able to pass through the blood-brain barrier. In human milk, less than 1% of the accepted dosage is found. 90–95% of metabolic changes in paracetamol are carried out in the liver. The elimination half-life is 2-3 hours. This component is excreted mainly by the kidneys, with urine.
Ibuprofen tablets "Junior Ibuklin" when taken orally, is almost completely absorbed from the digestive tract. The maximum level of the substance is reached in about 60-120 minutes. The elimination half-life is about 2 hours. Communication with plasma proteins - more than 90%. Ibuprofen gradually penetrates into the joint cavities, concentrates in synovial fluid, where its level is higher than in plasma. This substance is excreted mainly by the kidneys, some of it - with bile.
Consider indications for use for Ibuklin Junior with ibuprofen.
Indications for appointment
According to the instructions, the medication is indicated in children from 3 to 12 years of age when such pathological conditions occur:
- febrile syndrome;
- pain of various origins (sprain, toothache, dislocations, fractures);
- as an adjunct in the treatment of tonsillitis and other acute inflammatory diseases of the upper respiratory organs with an infectious lesion (tracheitis, pharyngitis, laryngitis).
Are there any contraindications to the drug?
List of contraindications
Absolute contraindications to the use of the drug "Ibuklin Junior" are:
- pathology of the optic nerve;
- peptic ulcer of the stomach or duodenum at the stage of exacerbation;
- aspirin asthma;
- impaired renal or hepatic function;
- hemorrhagic diathesis, bleeding disorders (hypocoagulation, hemophilia);
- bleeding of any genesis;
- lack of glucose-6-phosphate dehydrogenase;
- children under 3 years old;
- high sensitivity to the constituent elements of the drug, other NSAIDs, or to acetylsalicylic acid.
As relative contraindications, it should be noted:
- arterial hypertension;
- chronic heart failure;
- liver or kidney failure;
- hyperbilirubinemia;
- nephrotic syndrome;
- a history of peptic ulcer;
- gastritis;
- colitis;
- bronchial asthma;
- leukopenia and anemia of unknown origin.
Instructions for use
The Ibuklin Junior medication should be taken orally by dissolving the tablet in 5 ml of water. The interval between doses of the drug should be at least 4 hours, and with functional impairment of the kidneys or liver - 8 hours.
The daily dosage is recommended to be divided into 2-3 doses. The recommended dosage of the drug per day for children is: 3–6 years old with a body weight of 13–20 kg: 3 tablets; with a body weight of 20–40 kg (6–12 years) - up to 6 tablets.
The duration of the course of the drug without medical supervision as a means to lower the temperature should not be more than 3 days, and in the form of an anesthetic, 5 days.
Side effect
The medication "Ibuklin Junior" with ibuprofen can provoke the occurrence of the following adverse reactions:
- Digestive system: dyspepsia, with prolonged use of high doses - hepatotoxic effect;
- Hematopoiesis: agranulocytosis, thrombocytopenia, pancytopenia, neutropenia;
- Allergic phenomena: skin itch, urticaria, rash.
- Respiratory system: bronchospasm, shortness of breath.
- Urinary system: acute renal failure, allergic nephritis, nephrotic syndrome, swelling, cystitis, polyuria.
- CNS: cephalgia symptoms, dizziness, anxiety, insomnia, irritability, drowsiness, agitation, depression, hallucinations, confusion, in rare cases, aseptic meningitis (more often in patients suffering from autoimmune diseases).
- Sensory organs: tinnitus, hearing loss, visual impairment, toxic damage to the optic nerves, double vision or blurred vision, amblyopia, scotoma.
- Other: increased sweating.
When the above pathological reactions appear, it is recommended that the drug be interrupted and seek medical help. The dosage recommended in the instructions for Ibuklin Junior with ibuprofen must be strictly observed.
Overdose symptoms
An overdose medication can provoke the development of abdominal pain, nausea, vomiting, diarrhea, anorexia, epigastric pain, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, acute renal failure, coma, lowering blood pressure, bradycardia , tachycardia, atrial fibrillation, respiratory arrest.
The following therapeutic measures are recommended: gastric lavage (in the first hour after administration), alkaline drinking, sorbent intake, forced diuresis, symptomatic treatment aimed at correcting blood pressure and general condition of the patient. Other methods of therapy are determined individually and depend on the concentration of the drug in the patient's body.
Special recommendations
The decision to take the Ibuklin Junior medication with ibuprofen and paracetamol as an antipyretic drug is taken individually, depending on the tolerance and severity of the febrile syndrome. Caution must also be exercised when prescribing the drug to patients with infectious diseases, which is due to the high probability of masking the symptoms and difficulty in making a diagnosis. In order to reduce the risk of undesirable effects from the digestive system, it is recommended to use this drug in minimally effective doses, with a minimum course. When using Ibuklin Junior with ibuprofen for more than 5 consecutive days, monitoring of peripheral blood and liver status is required. In order to prevent distortion of the test results (quantitative determination of uric acid, serum glucose, 17-ketosteroids), it is recommended to cancel the drug 48 hours before they are performed.
At the time of taking this medication, it is advisable to refrain from driving vehicles and other complex mechanisms, since this requires the speed of psychomotor reactions.
Can Ibuklin Junior with ibuprofen be an adult?
Despite the fact that the pharmacological agent is intended for use by children, adults can also use it for all pathological symptoms indicated in the list of indications for use. However, in this case, it is necessary to correctly adjust the dosage of the drug.
Use in lactation and pregnancy
During pregnancy, it is possible to use the medication only at the minimum rate, as well as in cases where the benefit to the mother is higher than the risk to the fetus. Experimental studies have not revealed the embryotoxic, teratogenic and mutagenic properties of this drug. If you need a short dose during lactation, termination of feeding, as a rule, is not required.
Interaction with other medicines
The combined use of Ibuklina Junior with ibuprofen from temperature is contraindicated for children with other NSAIDs. Features of combination with other drugs:
- Paracetamol: increased risk of nephrotoxic effects.
- Anticoagulants, thrombolytic agents (anistreplase, alteplase, urokinase, streptokinase), colchicine, antiplatelet agents: the likelihood of hemorrhagic complications increases.
- Glucocorticosteroids, corticotropin, ethanol: the risk of erosive and ulcerative lesions of the digestive system increases.
- Indirect anticoagulants: control of blood coagulation is necessary.
- Hypoglycemic oral drugs, insulin: the hypoglycemic effect is enhanced.
- Diuretics, antihypertensive drugs: their effect is reduced.
- Digoxin, lithium preparations, methotrexate: their level in the blood rises.
- Caffeine: there is an increase in the analgesic effect of Ibuklin Junior with ibuprofen.
- Gold preparations, cyclosporine: nephrotoxicity is enhanced.
- Cefoperazone, cefamandol, cefotetan, plikamycin, valproic acid: the incidence of hypoprothrombinemia is more frequent.
- Colestyramine, antacids: the absorption of the drug is reduced.
- Myelotoxic agents: contribute to hematotoxicity.
Analogs
The following drugs are analogues of the Ibuklin Junior drug with ibuprofen:
- "Brufica Plus";
- "Brustan";
- "Next";
- Khayrumat;
- "Nurofen."
Only a doctor should select a replacement.
The most popular substitute is the drug "Nurofen." True, in its composition there is no paracetamol, so it is not so strong. Available in tablets, suspensions, rectal suppositories.
"Nurofen" for children, depending on the dosage form, is used to treat patients of different age groups: suppositories are prescribed for children from 3 months to 2 years, suspension - for children from 3 months to 12 years, tablets - for children from 6 years of age and adult patients .
All forms of drug release are used as a painkiller for the relief of head, ear, tooth, muscle, joint, menstrual, rheumatic pain, back pain, throat, neuralgia, migraines and other pathological conditions.
Reviews
The drug “Ibuklin Junior” with ibuprofen is mostly positive. Parents who gave this medicine to their children note that it is effective when other drugs do not help lower the temperature. In addition, it is noted that, subject to the rules described in the instructions, the results from Ibuklin Junior come much faster than from other means.
Among the side effects are mentioned loose stools and discomfort in the abdomen. As for the use of this medication by adult patients, such cases are also indicated in the reviews. Patients say that the medicine helped them very quickly, eliminated fever, muscle pain, and reduced symptoms of intoxication with colds. In the case of the use of the drug by adult patients, the dosage can be doubled, compared with the child. However, this should take into account body weight, perhaps the adult with a low weight and the maximum children's dose is suitable.
Doctors in the reviews note that Ibuklin Junior with ibuprofen for children is one of the most modern and effective means. Nevertheless, they warn that it is imperative to observe the intervals between doses of this medication, since when ingested large doses, there is a high probability of signs of an overdose.
Regarding analogues of this drug on medical sites, there are also some reviews. The most popular drug is Nurofen, which is available in a variety of dosage forms for various age categories of patients. This tool also relieves heat and muscle pain, but does not contain paracetamol. The drug “Next” is also mentioned, which has the same composition as “Ibuklin Junior”. This drug is also widely popular and in high demand in the pharmacy chain.
Despite its high effectiveness, the medication has some negative reviews that contain information that the medicine caused a lot of side effects. This, according to experts, is extremely rare, mainly in people suffering from allergic reactions and weak immunity. They experienced severe dizziness, severe dyspeptic disorders, headache, visual disturbances. In older people, the drug provoked an increase in blood pressure, increased heart rate, the occurrence of heart rhythm failures, etc. In these cases, the medication had to be canceled.