"Buspirone" refers to agents that affect the nervous system. It is an anxiolytic designed to eliminate anxiety and fear, normalize sleep, improve well-being in the presence of neurosis. Buspirone tablets have some contraindications and can cause side effects.
The composition and release form of the drug "Buspirone"
The drug is available in the form of tablets with a dosage of 5, 10 and 20 mg. The active substance of the drug is buspirone. Excipients include potassium hydroxide, starch from corn, magnesium stearate.
pharmachologic effect
The effect of the drug is sedative, anxiolytic. The medicine removes the symptoms of fear of a vegetative and mental nature. The mechanism of action of the drug is not fully established, but Buspirone is known to be different from benzodiazepines and other anxiolytic drugs.
There is no strong inhibitory effect on the central nervous system after taking Buspiron tablets. Instructions for use show that the drug reduces the formation of serotonin and its release, slows down serotonergic processes, helps block D2-dopamine receptors (postsynaptic and presynaptic endings), and accelerates the excitation of dopamine neurons located in the midbrain. After drug withdrawal, the occurrence of withdrawal symptoms and the return of anxiety are not observed.
The drug is intended for oral use. Penetrating into the body, for a short period of time it is completely absorbed into the digestive tract. As a result of intense metabolism, bioavailability is only 4%. The maximum level of the drug is reached in the blood about an hour after penetration into the digestive tract. Half-life is carried out in 2-3 hours, binding to plasma proteins corresponds to 95%. The continuous use of Buspirone does not affect its effectiveness.
During treatment, do not immediately expect the appearance of the effect of Buspirone. Instructions for use show that the effectiveness of the drug is manifested in the period from the 7th to the 14th day of its administration. The maximum effect of the medication appears after about 120 days of treatment.
Indications for the use of "Buspirone"
Specialists prescribe a medicine for sensations of danger, the identification of fear and anxiety, unmotivated irritability, mild neurosis and sleep disturbances, which are systematic. The tool is suitable for the treatment of somatic disorders, autonomic dystonia and depression, stress relief, alcohol withdrawal.
Contraindications to taking the drug "Buspirone"
Buspirone (including analogues of the drug) has contraindications. The original drug is prohibited to take in such cases:
- glaucoma (closed type);
- severe pathological processes in the liver and kidneys;
- epilepsy;
- cardiac abnormalities, problems with blood vessels;
- damage to the respiratory tract;
- myasthenia gravis;
- hypersensitivity to components;
- the period of gestation, breastfeeding;
- age less than 18 years.
If there is a history of convulsive seizures or epilepsy, it is strictly forbidden to prescribe Buspiron tablets to the patient.
Before starting therapy, the patient should be checked for sensitivity to the drug.
The use of the drug, dosage
During the treatment with Buspirone, the use of tablets is carried out in accordance with the recommendations of the attending physician. The official instruction contains information that each patient needs a different dose of the drug, because an individual treatment regimen determines the effectiveness of the therapy performed. Dosage depends on the patient’s health status. General recommendations are as follows:
- initial stage - 3 doses of 5 mg of the drug;
- continued therapy - a gradual increase in dose in compliance with the interval of 2-3 days (if there is such a need);
- the introduction of a maximum daily dose of 50 mg (in the absence of the desired effect).
"Buspirone" tablets are intended for use only in their entirety; they cannot be dissolved in liquids, crushed and chewed. The medicine is washed down with copious amounts of water, taken at any time of the day, regardless of food intake. The duration of the recommended course is 4 months. It is not recommended to be treated with Buspirone longer than this time.
Side Effects of Buspirone
During treatment with the drug, some unwanted reactions of the body can be detected. For example, drowsiness, general deterioration of health, weakness, fatigue, apathy. If such effects appear, drug withdrawal is required. It is worth contacting your doctor and tell him about negative changes in the body after taking Buspiron tablets. Instructions for use in such cases recommend reducing the dose. If the side effects do not disappear, the doctor should replace the drug with another, more suitable medication.
In very rare cases, the use of "Buspirone" leads to disturbances in the digestive system. For example, heartburn and nausea may occur, followed by vomiting. Pain in the epigastric region is possible. Other adverse reactions may appear. All these manifestations indicate intolerance to the components of the drug.
Overdose of the drug "Buspirone"
If the drug is used in doses higher than recommended, a person may experience symptoms of an overdose. These include nausea with vomiting, gastrointestinal disorders of a different type. The patient is dizzy, the pupils narrow, a short loss of consciousness is possible. Patients who left reviews after treatment with Buspirone Sandoz noted the possibility of confusion, tremor of the upper extremities. Other manifestations of overdose include irritability, irritability, and frequent mood swings. An overdose is treated by washing the stomach, injecting activated charcoal into the body, symptomatic therapy and constant monitoring of blood pressure, heart rate, and respiratory activity. There is no specific antidote to eliminate the symptoms of an overdose of Buspirone. Dialysis in such situations does not bring the desired effect.
Interaction with various substances and other medicines
Sometimes, when it is forbidden to combine certain drugs with Buspiron tablets, it is recommended that the instructions for use be considered analogs as a replacement for the original product. It is known that the medication should not be taken simultaneously with tranquilizers, sedative drugs due to the increased effect of the drugs taken. During treatment with "Buspirone" it is necessary to exclude the use of alcoholic beverages. Do not combine medication with the use of MAO inhibitors because of the risk of hypertensive crisis.
With the simultaneous use of "Haloperidol" with "Buspirone" in the blood, the level of this drug increases. The combination of the drug with "Trazodone" leads to a significant increase in ALAT.
As a result of experiments in which animals participated, no negative effects on the body during the treatment period were detected. However, in order to avoid unwanted reactions of the body, it is worth refusing to take it.
"Buspirone" instructions for use are as a means, the metabolism of which is carried out in the liver. In this process, CYP3A4 is involved, which is an isoenzyme that facilitates the processing of the drug by the body. For this reason, Buspirone may interact with drugs that relate to inducers or inhibitors of the enzyme.
Features of the use of the drug
If during lactation there is a need for therapy based on the reception of "Buspirone", breast-feeding is temporarily stopped.
With impaired functioning of internal organs, there are some limitations. For example, if you have liver problems, you should be careful during the treatment period and constantly monitor changes that occur with health. Contraindications are only severe violations in the functioning of the body. The same applies to kidney function.
Regarding the appointment of funds from different manufacturers, including the drug "Buspirone Sandoz", reviews of doctors indicate the need to comply with certain rules. When prescribing a medication, a specialist should take into account that this remedy is not able to eliminate the symptoms of withdrawal symptoms resulting from the use of benzodiazepines, and its purpose in such situations is not possible if a gradual withdrawal of the anxiolytic drug was not performed before therapy.
Patients should be aware that Buspirone tablets may affect alertness, especially at the initial stage of therapy, therefore it is better to temporarily refrain from activities involving special responsibility and increased concentration of attention. Performing certain tasks can be potentially hazardous to your health.
As for therapy with Buspirone, the doctors' comments about the drug are mostly positive. However, experts note that it should be prescribed correctly, only if there are appropriate indications and in optimal doses. It is worth noting that with the stress and anxiety that appear due to the constant negative impact of everyday stressful situations, treatment with the use of anxiolytics is usually not necessary.
Patients taking Buspirone with a different dosage, for example Buspirone 10 mg, reviews show how to use an effective drug. People who have been treated with this medication note that the doctor warned them about the caution of using certain medications, for example, oral contraceptives, medicines for diabetics, drugs that are aimed at lowering high blood pressure, drugs to eliminate depression and drugs such as cardiac glycosides antipsychotics.
Renal and liver failure of moderate severity, cirrhosis require a reduction in standard doses. In these cases, the reception of “Buspirone Sandoz” is described by people as a treatment that must be carried out under the supervision of a doctor. You should pay attention to the slightest changes in well-being.
In patients with epilepsy, the medicine is never prescribed because of the risk of seizures. Such therapy for this category of patients is dangerous and should be carried out using other medications. Patients who often abuse drugs and have a history of drug dependence should be treated under the strict supervision of a specialist (there have been no cases of addiction to Buspirone).
Studies have shown that "Buspirone" after 3-4 weeks of use with anxiety is ineffective, so it makes no sense to be treated with it for a long time. Due to the lack of information on the safety of the drug for children, its administration is not performed for persons under 18 years of age.
The treatment with different versions of the drug and Buspirone Hexal reflects reviews of some experts as ineffective therapy because sleep problems, irritability, and anxiety conditions are sometimes a sign of serious psychomotor disturbances.
Analogs, reviews about the drug "Buspirone"
Substitution of the drug with an analogue should be done after consulting a doctor. There is a good substitute for the drug "Buspirone" - "Spitomin." Reviews of patients show that its action is similar to the action of the original product. Apply "Spitomin" to treat those conditions that stop and "Buspirone". The reviews are good, therefore, if necessary, it is quite possible to use this substitute, but only after consulting a specialist. A similar effect is achieved due to the presence of the same active component. Spitomin is most effective in treating patients with anxiety disorders.
After treatment with Buspirone, patients may leave different reviews, but basically the result of such treatment is positive. Is its effectiveness really confirmed? Doctors' reviews show that the drug with the active component of buspirone hydrochloride successfully fights anxiety manifestations that vary in severity and origin, but its effect is immediately imperceptible, it can be seen only after a certain time, namely, after one to two weeks. To see the maximum possible therapeutic effect, you need to be treated for one month.
Buspirone receives positive feedback from patients in cases where there were no side effects, and the drug coped with its task perfectly. Sometimes negative reactions of the body occur, but very rarely when the body does not perceive the components of the drug. From the reviews it became known that the treatment may be accompanied by psychotherapeutic and sociotherapeutic measures. Sometimes patients have a negative reaction of the gastrointestinal tract, dizziness and weakness. Overdose is a rare occurrence.
As a result of the use of the drug "Buspirone", patients who have undergone treatment are rarely left with information about serious side effects. The course should be based on the individual characteristics of the human body, its state of health, and in optimal doses for each particular case. Despite the constant monitoring of the doctor, the patient is obliged to study the instructions before starting treatment.
"Buspirone" is a drug that usually does not lead to the development of side effects and overdose, is not addictive, negative manifestations after its cancellation, and in most cases copes with its task.