In the article, find out whether Monural is an antibiotic or not? After all, it is often prescribed for cystitis. To begin with, cystitis is a typically female disease in which inflammation occurs in the urinary tract. The main reason is infection (fungi of the genus Candida, chlamydia, ureaplasma). The disease often occurs in the weaker sex due to the anatomical features of the body - a short and wide urethra. For a quick recovery, recovery, it is important to determine the disease on time, therefore it is recommended to find out in advance how cystitis manifests itself in women.
Inflammatory pathologies of the urinary tract are often the reason for prescribing the studied medication to patients. The greatest prevalence of such diseases among women, due to the anatomical features of the structure of the urethra of women, however, men suffer from similar diseases, only slightly more rarely. However, many patients are interested in the question: "" Monural "- an antibiotic or not."
The content of this pharmacological agent contains the active element fosfomycin, the main function of which is to destroy pathogenic bacteria and prevent their further reproduction. As a result of this property, the Monural medicine can rightfully be considered an antibiotic.
Before using this tool, you need to consult a doctor, self-medication is prohibited due to the possible occurrence of adverse reactions.
Release form and composition of the medication
What is Monural's antibiotic group? It belongs to the group of fosfomycin. This is an antibacterial medication that is used in the treatment of infectious diseases of the genitourinary system.
This medicine is in the form of granules for the preparation of oral solutions. Granules are characterized by white color, tangerine smell. Dosage - 2 and 3 g in multilayer laminated sachets. The carton contains 1 or 2 bags.
The granule of the Monural cystitis antibiotic granules contains the active element fosfomycin in the form of tromethamol fosfomycin, as well as additional substances - saccharin, sucrose, orange and mandarin flavorings.
pharmachologic effect
The medicine "Monural" has powerful bactericidal properties. The active substance of this medication is tromethamol fosfomycin, which refers to antibiotics of a wide therapeutic spectrum, derivatives of phosphonic acid. The principle of its action is due to the suppression of the initial stages of the synthesis of the cell wall of harmful bacteria. The substance competes with N-acetyl-glucosamine-3-o-enolpyruvyl transferase (enzyme), due to which there is a specific, irreversible and selective suppression of the above enzyme. As a result of this action, there is a lack of cross-resistance with other categories of antibacterial agents and the likelihood of synergism (synergism is observed with amoxicillin, cephalexin, pipemidic acid).
In addition, this drug exhibits high functionality against most gram-negative and gram-positive microbes, which include:
- Morganella morganii;
- Enterococcus spp .;
- Serratia spp .;
- Staphylococcus aureus;
- Pseudomonas spp .;
- Staphylococcus spp .;
- Enterococcus faecalis;
- Staphylococcus saprophyticus;
- Klebsiella pneumonia;
- Proteus mirabilis;
- Citrobacter spp .;
- Escherichia coli;
- Klebsiella spp .;
- Enterobacter spp.
In addition, fosfomycin contributes to a significant decrease in the adhesion of a number of pathogenic bacteria on the epithelium of the urinary canal.
How does the Monural antibiotic work with cystitis in women?
Pharmacokinetics
Fosfomycin trometamol after oral administration is rapidly absorbed from the structures of the digestive tract. With a single dose of 3,000 mg of the main element, the bioavailability is equal to 34-65%. The period the substance reaches its maximum concentration in the blood ranges from 2 to 2.5 hours.
Phosphomycin does not bind to plasma proteins trometamol, dissociates in the body into fosfomycin and trometamol, and subsequently is not metabolized. The main substance accumulates in the urine. When taking a single dosage of more than 3000 mg in the urine, a high level (1,053–4,415 mg / l) is observed for most of the most common pathogens of urinary tract infections, this concentration is 99% bactericidal. The half-life of blood is 4 hours. Excretion occurs in unchanged form by the kidneys (up to 95%), approximately 5% of the substance is excreted in the bile.
With a moderate degree of decrease in renal function, including its physiological decrease in old age, the elimination half-life of fosfomycin slightly lengthens, while its level in the urine remains in the form of therapeutic concentrations.
Indications for appointment
Antibiotic for cystitis "Monural" is prescribed for such pathological conditions:
- non-specific bacterial urethritis;
- acute attacks of recurrent bacterial cystitis ;
- acute bacterial cystitis;
- infection of the urinary organs in the postoperative period;
- massive asymptomatic bacteriuria during pregnancy;
- infection of the urinary tract during surgical interventions and diagnostic transurethral studies (for preventive purposes).
Does he have any contraindications? About it further.
List of contraindications
According to the instructions for the antibiotic "Monural", it has some restrictions on use. These include:
- renal failure (creatinine clearance less than 10 ml per minute);
- high sensitivity to the elements of the composition of the tool;
- age less than 5 years.
During pregnancy and lactation, the Monural medication is prescribed only in cases where the intended benefit of the treatment for the woman is higher than the possible harm to the child. In any case, the decision should be made by the doctor.
So, Monural is an antibiotic or not, we found out.
Rules of use and dosage
The drug is intended for oral administration, after dissolving the contents of the sachet in 1/3 glass of water. If the medicine is taken on an empty stomach, then it should be done 2 hours before or after a meal. It is preferable to take the drug in the evening, immediately before bedtime. Previously, patients are advised to completely empty the bladder cavity.
The dosage prescribed for adult patients is 3 g of a drug once. In the treatment of recurrent or severe infectious diseases of the urinary system, as well as in old age, you may need to reuse the Monural medication every other day in the same dosage.
In order to prevent the likelihood of infection of the urinary organs during transurethral diagnostic procedures and surgical interventions 3 hours before their implementation and one day after the initial intake, 3 g of the drug is also prescribed.
For children after the age of 5, this pharmacological agent is prescribed only once in a dosage of 2 g.
Patients with diagnosed renal insufficiency need to reduce the dose and extend the interval between doses.
Side effects
Antibacterial medication "Monural" from the group of antibiotics of phosphomycin can provoke the development of pathological adverse reactions:
- Digestive system: heartburn, dyspeptic symptoms.
- Other: skin rashes, allergic reactions.
Therefore, it is necessary that the doctor supervise the treatment. Although the risk of side effects after the Monural antibiotic is minimal, you should not be neglected. In case of an overdose, the implementation of forced diuresis is recommended.
Special recommendations
Patients with diabetes mellitus when using this medication should take into account that in the granules of one sachet with a dosage of 2 g of the drug, 2.1 g of sucrose is present, with a dosage of 3 g - 2.213 g of sucrose.
Breastfeeding and pregnancy are included in the list of relative contraindications to the prescription of the drug "Monural". Conducting therapy is possible after assessing the ratio of risk and intended benefit.
In accordance with the instructions, this medication is contraindicated in children under the age of 5 years.
In case of impaired kidney function
If a person has renal failure, correction of dosing regimens is necessary. In severe cases of renal failure (creatinine clearance <10 ml / min), treatment with this drug is contraindicated. Therefore, do not self-medicate.
Drug interaction
With the combined use of the drug "Monural" with metoclopramide, a decrease in the concentration of fosfomycin in blood serum and urine may be observed. Thus, a combination of these medications is not recommended.
How is Monural combined with other antibiotics? This tool can be combined with the administration of drugs of other pharmacological groups. This medication is often prescribed in combination therapy with antibacterial drugs such as Nolitsin, Ceftriaxone, and others.
What group of antibiotics Monural belongs to is now known. How can it be replaced?
Analogs
Preparations identical in therapeutic properties to the Monural agent are:
- "Ecofomural" is a Russian-made medicine that is used to treat bacterial infections of the urinary organs of different localization, provoked by pathogenic microorganisms sensitive to the main component (phosphomycin). They may be asymptomatic bacteriuria and uncomplicated urinary tract infections of acute origin. The drug is also prescribed for the prevention of such pathologies after diagnostic transurethral studies and operations.
- “Espa-Focin” is a German-made antibiotic, an antimicrobial medicine for systemic use, based on the main active elements - tromethamol fosfomycin.
- Urofosfabol is a Russian medicine, an absolute structural analogue of the Monural drug, which has identical properties and indications for its intended use.
- “Cistoral” is a cheaper Russian analogue of “Monural”, which is intended for the treatment of acute uncomplicated urinary tract infections caused by the penetration of microorganisms sensitive to fosfomycin. This tool is used after 12 years.
Price
The drug "Monural" can be purchased at any pharmacy network. Its cost varies between 340-390 rubles per bag containing 2 g of the drug. And in the range of 420-550 rubles for a bag of 3 g.
Reviews about the antibiotic Monural
On medical sites and patient forms, you can find a huge number of responses about this medication, most of which contain positive information about its effect and tolerance to the body.
Patients who used the Monural medication note that this is a very modern, safe and extremely effective drug. It is known that infectious diseases of the urinary tract most often occur in women, due to the anatomical features of the body, so most of the reviews about the drug were left by women.
Patients note that after taking the medicine, the symptoms of the disease begin to disappear after a couple of hours. If the medication is prescribed for cystitis, then frequent urination and burning during it disappear within a few hours. If the antibiotic was drunk before bedtime, then in the morning the symptoms of cystitis are no longer observed. In addition, patients described Monural as a drug that practically does not cause adverse reactions and is very well tolerated. Patients note that the medication is prescribed even for diseases such as urethritis and inflammation of the kidneys, and its effectiveness in these pathologies is no less high.
We examined whether Monural is an antibiotic or not. We hope the information provided will help you.