How should I use the Dayvonex drug for psoriasis? You will find reviews about this medication in the materials of the presented article. We will also tell you about the form in which this product is made, what is included in its composition, how much it costs, what properties it has, and more.
Composition, packaging, release forms
What forms of Dayvonex should be used for psoriasis? Reviews say that this tool is available in three different forms. Consider their composition and packaging in more detail.
- "Dayvoneks" - ointment, the active substance of which is calcipotriol. As additional ingredients, the drug contains liquid paraffin, propylene glycol, water, macrogol stearate, Trilon B, white soft paraffin, α-tocopherol and sodium hydrogen phosphate dihydrate. On sale such a tool can be found in aluminum tubes of 100 and 30 g.
- "Dayvoneks" - a cream whose active ingredient is calcipotriol in the form of a monohydrate. The preparation also contains prepared water, glycerin, liquid paraffin, sodium hydroxide, cetearyl alcohol, soft white paraffin, macrogol cetostearate, sodium hydrophosphate dihydrate, trilon B and chlorallylmethamine amine. On sale, such a tool comes in aluminum tubes of 100 and 30 g.
- "Dayvoneks" - a solution whose active substance is calcipotriol in the form of a monohydrate. As additional components, propylene glycol, prepared water, HPC, levomenthol, isopropanol and sodium citrate are used. On sale, this form of the drug comes in a 60 ml bottle of polyethylene.
Pharmacological action of the drug
How does the Dayvonex drug work with psoriasis? Experts say that its active substance, calcipotriol, is an analogue of the active metabolite of vitamin D₃. It is he who inhibits the activation of T-lymphocytes, which is caused by interleukin 1.
The therapeutic effect of the drug is due to the stimulation of morphological differentiation, as well as the suppression of the proliferation of keratinocytes.
Experts say that calcipotriol has a very weak effect on calcium metabolism, compared with calcitriol.
Features of the external drug "Dayvoneks"
Is the Dayvonex Medication Hormonal? The instructions attached to this tool, states that, unlike the drug "Daivobet", the drug in question is not hormonal.
A feature of this medication is that it inhibits the growth of epidermal cells, the excessive growth of which is the cause of psoriasis.
As practice shows, the drug in question shows its effectiveness after about one to three weeks of active use.
Pharmacokinetic properties of an external agent
Does the preparation “Dayvoneks” take place? The instruction says that its active substance is absorbed by about 1-5% and undergoes biotransformation in the liver. After that, inactive metabolites are formed in the patient's body.
The half-life of the drug substance is quite short.
Indications for use of ointment, cream and solution
Why use Dayvoneks medication, the price of which is indicated below? Most often, this drug is prescribed for monotherapy of a disease such as psoriasis, including the form that affects the scalp.
There are reviews of patients who indicate that both stationary and regressing forms of the disease respond to treatment with this drug.
In addition, this medication is often used in the treatment of skin disease in conjunction with drugs such as Acitretin, Cyclosporin and corticosteroids.
By the way, the Dayvoneks solution (lotion) is used only in areas with hair.
Contraindications
What are the contraindications of Dayvoneks? Ointment and cream should not be used in the following cases:
- in diseases accompanied by a violation of calcium metabolism;
- in adolescence and childhood (up to 18 years);
- with hypersensitivity to calcipotriol, as well as other components of the drug.
As for the solution, it also has its contraindications. It can not be used with:
- hypercalciuria;
- hypersensitivity to the elements of the product;
- hypervitaminosis D;
- nephrolithiasis;
- hypercalcemia.
It can not be said that the drug in question is prescribed with extreme caution to patients with:
- nephrolithiasis;
- liver failure;
- acute renal failure;
- over the age of 60.
Instructions for use of the external agent
How to use the drug "Dayvoneks" with psoriasis? Reviews regarding this remedy state that the cream and ointment must be applied to the affected areas twice a day.
The permissible amount of cream is not more than 15 g per day, or 100 g per week.
Ointment "Dayvoneks" is undesirable to assign to children and adolescents under 18 years of age. But in case of emergency, when other drugs were ineffective, it is still used. A child of 6-12 years of age is given a medicine twice a day. The maximum weekly dosage for this age is 50 g.
Adolescents after 12 years are allowed to use a weekly dosage of 75 g.
Therapy with Dayvonex in children should be short-lived. Moreover, the medication must be applied to a small area of the skin (not more than 30% of the entire surface area of the body).
The drug in the form of a cream for the treatment of psoriasis is used no longer than 7-8 weeks, but in the form of ointments they are used for up to a year.
As mentioned above, the Dayvoneks solution is mainly used to treat a disease that has appeared on the scalp. A kind of lotion is applied to the affected areas twice a day and rubbed well.
Up to 60 ml of solution can be used per week. Complex treatment is also possible. It provides a combination of Dayvonex cream and solution. It should be borne in mind that the weekly dosage should not exceed 5 mg (i.e. 30 ml of solution and 60 g of cream or 30 g of ointment and 60 ml of solution).
Overdose
What symptoms of overdose occur when exceeding the recommended doses of Dayvoneks? Analogues and the drug itself in high doses can lead to an increase in the concentration of calcium in the blood. Against this background, the patient appears thirsty, there is a decrease in muscle tone, constipation, a decrease in concentration and fatigue.
If such signs appear, you should immediately stop using the medication.
Adverse reactions
There are quite a few side effects that may occur while using a cream, ointment, or Dayvonex solution. The most common manifestations include the following reactions:
- swelling of the face;
- allergic reactions (dermatological);
- depigmentation, which is reversible;
- hypercalcemia;
- periorbital edema;
- contact dermatitis;
- erythema;
- irritation of the skin at the site of application of the ointment, cream or lotion;
- reversible hyperpigmentation;
- various types of rash;
- peeling of the skin;
- skin burning;
- itching
- angioedema;
- eczema;
- exacerbation of the psoriatic process;
- dry skin
- hypercalciuria;
- photosensitivity.
To eliminate such symptoms, the patient should increase fluid intake. Also, if adverse reactions occur, the patient undergo hemodialysis (if renal failure occurs), forced diuresis, and also give corticosteroids and potassium chloride is administered. In this case, the daily volume of urine and the level of electrolytes are constantly monitored.
Drug interaction
The drug "Dayvoneks" is forbidden to use simultaneously with drugs, which include salicylic acid, as well as its derivatives.
Special instructions for using the product
Before using any form of the “Dayvonex” preparation, it is imperative to familiarize yourself with the attached instructions. It states that:
- It is highly recommended not to apply the cream in question to the face. To avoid such contact, wash your hands thoroughly with soap after each use of the medication.
- Do not apply Dayvonex on large areas of the skin (more than 30%). If such a need still arises, then you should regularly monitor the concentration of calcium in urine and blood.
- Hypercalcemia usually develops when using high doses of the drug. When it is canceled, the calcium concentration quickly normalizes.
- The cream contains a component such as cetostearyl alcohol. This substance can easily cause a rash.
- When using the drug, patients are better off avoiding excessive exposure to artificial or natural sunlight.
- The active substance of the drug does not affect the person’s ability to drive complex mechanisms or vehicles.
Medication "Dayvoneks": analogues and price
The most popular and effective analogues of the drug in question are drugs such as Daivobet, Glenriaz, and Psorkutan. Before using the listed medicines, you should definitely consult a dermatologist.
How much is the Dayvonex drug? The price of this tool depends on the form of its release and volume. The average cost of the drug in Russia is from 800 to 1200 rubles.
Reviews about the drug
According to reviews of such a drug as Dayvoneks, it does not help with psoriasis in all cases. In this regard, an ointment, cream or solution should be used only as directed by a narrow specialist (i.e. a dermatologist).
It should also be noted that most experts, however, note that the Dayvoneks and Dayvobet medicines are the main means that are actively used to treat vulgar psoriasis.