"Longidase" is an enzyme preparation. The medication is made in the form of a lyophilisate for the manufacture of a solution for intramuscular and subcutaneous injections. In addition, the medicine is available in the form of rectal and vaginal suppositories. What is part of Longidaza?
Suppositories for rectal or vaginal use include a hyaluronidase conjugate with polyoxidonium. An auxiliary component is cocoa butter.
A powder bottle contains a hyaluronidase conjugate. An additional substance in the composition of "Longidaza" is mannitol.
Healing properties
According to the instructions for use, it is known that the drug has a prolonged effect, and also has an antioxidant, immunostimulating and anti-inflammatory effect.
"Longidase" has an anti-fibrotic effect, facilitates the course of the inflammatory disease, which is in the acute phase.
With subcutaneous or intramuscular administration, together with other injectable drugs, Longidaza enhances their absorption, and with the introduction of local analgesics, the drug accelerates analgesia. Why is Longidaz prescribed?
According to the instructions for use, it is known that the use of pharmacological dosages of the drug during surgery does not adversely affect recovery in the postoperative period. In addition, after surgical intervention does not provoke the progression of the infectious process.
Indications for use of "Longidase"
According to the instructions for use, it is known that the lyophilisate for the manufacture of a solution for injection is recommended for adults with diseases that are accompanied by an increase in connective tissue:
- Adhesions in the pelvis.
- Chronic endometritis (an inflammatory lesion of the inner layer of the uterus that can be triggered by various pathogens).
- Intrauterine synechiae (fusion inside the uterus, which are a complete or partial infection of the uterine cavity).
- In chronic prostatitis (inflammation of the prostate gland, which leads to a violation of the morphology and functioning of the prostate).
- Interstitial cystitis (a clinical syndrome in which an inflammatory process of a non-infectious nature develops that affects not the mucous membrane of the bladder, but the tissue located between it and the muscle).
- In adhesions after surgical manipulation of the abdominal organs.
- In the presence of hypertrophic scars (a type of scar tissue characterized by an excess of fibrous fibers).
- Pyoderma (pustular skin diseases caused by pyogenic bacteria, the main of which are staphylococci and streptococci).
- Long non-healing wounds.
- Limited scleroderma (a chronic disease that leads to the replacement of connective tissue with non-functional scarring).
- With the forming scars after injuries, operations.
- Pneumosclerosis (pathological replacement of the connective lung tissue as a result of inflammatory or dystrophic processes in the lungs).
- Fibrosing alveolitis (a disease that is caused by diffuse lesions of pulmonary interstitium with the development of respiratory failure).
- With tuberculosis (an infectious disease caused by mycobacterium tuberculosis and accompanied by the formation of granulomas in various organs).
- With tuberculoma (a form of pulmonary tuberculosis that looks like a tumor).
- Joint contracture (sustained restriction of movement in the joint).
- Arthrosis (a chronic joint disease with slow cartilage destruction, as well as an increase in pathological changes in the synovial membrane).
- With ankylosing spondylitis (chronic systemic joint inflammation that affects the spine and limits its mobility).
- Hematomas (a type of bruising, limited accumulation of blood with closed and open injuries of organs and tissues with rupture (injury) of blood vessels; in this case, a cavity containing liquid or clotted blood is formed).
Any form of release "Longidaza" is also used in conjunction with antibiotics in gynecology, urology, dermatovenerology, pulmonology, as well as with local painkillers.
Suppositories for rectal or vaginal administration are prescribed for adult patients and adolescents from 12 years of age for complex therapy, or for monotherapy of diseases.
Indications for use of "Longidaza":
- Chronic endomyometritis (an inflammatory lesion that affects the mucous membranes and muscle of the uterus).
- Tubal peritoneal infertility (the impossibility of conception as a result of a violation of the patency of the fallopian tubes, when the egg formed in the ovary cannot penetrate the uterine cavity where the sperm must meet).
- Prevention and therapy of adhesions in the pelvis in the chronic form of inflammatory pathologies of the internal genital organs.
- Ureteric and urethral strictures (abnormal narrowing of the ureter canal, completely or partially violating its patency).
- Peyronie's disease (deformation of the penis during an erection).
- The initial stage of a benign enlargement of the prostate gland (a benign mass that develops from the glandular epithelium or the stromal component of the prostate).
- After surgery on the urethra, ureters.
- Limited scleroderma (a chronic disease that leads to the replacement of connective tissue with a non-functional scar).
- Interstitial pneumonia (chronic lung tissue lesions, which are manifested by inflammatory lesions and impaired alveolar wall structure, as well as endothelium of the pulmonary capillaries, perivasal and perilymphatic tissues).
- Pneumofibrosis (the process of proliferation of connective tissue of the lungs, which occurs under the influence of dystrophic or inflammatory processes).
- Tuberculosis.
- Fibrosing alveolitis (a pathological process based on extensive damage to the interstitial tissue of the lungs, leading to the development of fibrotic changes and respiratory failure).
- Siderosis (a type of pneumoconiosis that develops when working in dusty conditions with small metal chips).
- Pleurisy (inflammation of the pleural leaves, with fibrin falling onto their surface).
- Non-healing wounds.
Limitations
According to the instructions for use, it is known that contraindications to "Longidaz":
- Hemoptysis (coughing up sputum with blood from the larynx, bronchi or lungs).
- Pulmonary hemorrhage (a complication of various diseases of the respiratory system, which is accompanied by the outflow of blood from bronchial or pulmonary vessels).
- Malignant tumors.
- Acute kidney disease.
- Period of pregnancy.
- For solution - up to 18 years, for candles - up to 12 years.
- Fresh hemophthalmus (hemorrhage into the vitreous body of the eyeball and its surrounding structures, caused by damage to the vessels of the retina and subretinal space).
- Breast-feeding.
- Acute infectious diseases.
- Increased individual sensitivity to hyaluronidase-based drugs.
With extreme caution, Longidase is recommended for chronic kidney diseases.
How to use the solution
Before the injection, 1.5-2 milliliters of a 0.5% solution of procaine or water for injection should be added to the contents of the ampoule or bottle with powder. Ready solution is not subject to storage.
The doctor determines the necessary dosage based on the patient’s individual indicators, as well as the severity of the disease and age. Subcutaneous injections are used under scarred tissue or next to the affected area.
According to the instructions for use, it is known that the standard dosage of Longidase prostatitis medication is 3000 IU once a day every 3-10 days. Given the severity of the disease, five to fifteen injections are prescribed.
If necessary, repeat therapy should be carried out after two to three months. After undergoing the prescribed treatment, which is complicated by a severe chronic form in the connective tissue, the patient is prescribed a maintenance concentration of 3000 IU per day with an interval between injections of two weeks.
The use of injections "Longidaza":
- Respiratory system: intramuscularly - 3,000 microunits every five days, 10 injections per course. Further, therapy is possible, which varies from 3 to 12 months in the same concentration with a time interval between procedures of two weeks.
- For lesions of the pelvic organs, intramuscular injections of 3000 IU are also prescribed once every 5 days, the duration of therapy is 5-15 injections.
- With limited scleroderma, they are prescribed intramuscularly at 3000-4500 IU per day every three days, the course of therapy is from 5 to 15 injections, the duration of treatment and dosage are selected by the doctor depending on the patient's characteristics.
- With hypertrophic scars after burns, as well as pyoderma and surgical interventions, 3000 IU are used intramuscularly per day with a time interval between injections of three to five days, the duration of therapy is no more than 10 injections subcutaneously or intramuscularly - from 1 to 2 times a week.
When is the drug prescribed? If the wounds do not heal for a long time, then 1500-3000 IU are administered intramuscularly every 5 days, the course of therapy is 5-7 injections.
According to the instructions for use, it is known that for arthritis, hematomas, injections are administered intramuscularly at 3000 IU per day every 7 days, the total duration of therapy is from 7 to 15 injections.
In case of adhesive disease, 3000 IU are administered intramuscularly per day after 3-5 days, the course of treatment with Longidase varies from 7 to 15 injections.
To increase the bioavailability of antibiotics and anesthetics, 1,500 IU is prescribed every 3 three days, the duration of therapy is no more than 10 injections.
Candle application
According to the instructions, suppositories are prescribed rectally or vaginally 1 time per day before going to bed. According to the instructions for use with "Longidaz" in gynecology, the candles are injected into the vagina in a supine position.
With rectal administration, suppositories must be used after preliminary bowel movement. The general course of therapy varies from 10 to 20 suppositories. The frequency of use of the drug depends on the severity, as well as the duration of the disease.
In urology, Longidazu is used for 1 suppository every two days, the duration of therapy is 10 procedures. Then, with a time interval of three days, 10 suppositories, the duration of treatment is 20 suppositories.
In dermatovenerology, 1 candle is recommended for use after one to two days, the duration varies from 10 to 15 injections.
In surgery, 1 suppository is used every three days, the duration of treatment is 10 procedures.
According to the instructions for use with Longidase, suppositories in gynecology are used both rectally and vaginally: 1 suppository once every two days, the duration of therapy is 10 injections.
In pneumology, 1 suppository is prescribed once every two days, the duration of treatment varies from 10 to 20 applications.
As a supportive treatment, it is recommended to use 1 suppository once every five to seven days, the duration is from three to four months.
The implementation of re-therapy is possible after three months. In patients with kidney disease, the frequency of application of the solution or suppository should not exceed once a week.
Side effects
According to the instructions for use, it is known that the substances that make up "Longidase" in rare situations can provoke the occurrence of allergic reactions. A negative effect with the injection can be a pain at the injection site, and sometimes swelling, redness of the skin.
Such side effects are temporary and disappear after 2-3 days. The use of suppositories in rare situations can provoke increased sensitivity, which is characterized by hyperemia, edema, and itching.
Application features
When allergies occur, the use of "Longidaza" must be immediately canceled. It is forbidden to use the solution in the area of ​​the tumor, as well as acute inflammation or infection.
With an exacerbation of the disease, the use of the drug must be prescribed in combination with antimicrobial agents. If it is necessary to discontinue treatment with "Longidaza" drug cancellation can be carried out without gradually reducing the concentration of the drug. Having skipped the next dosage, the subsequent injection is carried out in the standard mode, which is indicated in the annotation or recommended by the doctor.
Do not use doubled dosage to compensate for the previous one. Before starting treatment, the patient is obliged to notify the doctor of all the medicines that are currently being taken.
Women in position and during lactation are prohibited from using the drug. It is contraindicated for patients with acute kidney diseases to use any form of Longidase release.
Recommendations
Neither suppositories, nor Longidaza injections have any effect on car driving, nor do they reduce attention and the speed of psychomotor reactions.
Before therapy, it is necessary to consider the compatibility of Longidase with other drugs, as well as substances and its effects on humans.
Alcohol and Longidase Compatibility
The drug should not be consumed with alcohol. The minimum time that must pass before using the medication is 8 hours after drinking alcohol by men and 14 hours - by women. You can take alcohol a day before injections or the use of suppositories.
According to doctors, it’s generally better to refrain from drinking “alcoholic beverages” during therapy. During the disease, the body has reduced immunity, and resistance to the disease is reduced. Additional load on the liver and internal organs during the processing of ethanol is unacceptable.
There is no difference which Longidase dosage form is used for treatment: injections or suppositories, the active substances affect the body the same way.
In the liver, as well as blood flow when exposed to the products of the processing of wine alcohol, the effect of "Longidase" is reduced. Therefore, the drug is not recommended to be combined with alcoholic beverages.
The main rules for taking products that contain ethanol, and drugs without harm to health:
- Take the medicine two days before drinking.
- Do not exceed a safe concentration of alcoholic beverages, regardless of type - wine, beer or something strong.
- Drink enough water during a hangover.
- Continue drug therapy after removing alcohol from the body (2 days).
The main mistake people make is non-compliance with the last paragraph. On the day when it is necessary to continue using the medicine, it is required to completely abandon alcohol. To use alcohol in the treatment of "Longidaza" or not, it is up to the individual.
Doctors require ethanol to be excluded during therapy. After the end of Longidaza therapy, the recovery course may last, therefore the terms for resolving libations are postponed.
But it is best to exclude alcohol from the diet for the entire duration of therapy. If this is not done, then the effectiveness of the treatment will greatly slow down. Since the composition of "Longidaza" contains such substances that are designed to regulate the processes of creating tissue materials, it is used in medicine to stop the growth of tissue cells.
Drug Interactions
Longidase can be used with antibacterial, antiviral, bronchodilator, antifungal agents, as well as glucocorticosteroids, cytostatics.
Adrenocorticotropic hormone, cortisone, increased concentrations of estrogen can lower the effect of the enzyme hyaluronidase. The drug increases the effect of local pain medication. What can replace Longidaz?
Generics
Longidaza substitute drugs are:
- Lidase
- "Polyoxidonium"
- "Ronidase."
- Biostrept.
- "Distreptaza".
- "Liraza".
- Laprot.
The analogue of Longidase in tablets is Polyoxidonium.
"Longidaz" must be protected away from children. Keep the medicine at a temperature of 2 to 15 degrees away from light in a dry place. Shelf life is 24 months.
Powder for the manufacture of injections is available by prescription, suppositories - without a prescription. The cost of the drug varies from 1,500 to 3,000 rubles. Manufacturer "Longidazy" - the Russian pharmaceutical company "NPO Petrovax Pharm".
Reviews about "Longidaz"
Patients leave only good responses about the drug. Both suppositories and lyophilisate show increased effectiveness with fresh adhesions, and also help the resorption of old scars and prevent the formation of new ones.
For women, as a rule, a medication helps with gynecological diseases."Longidaza" helps to eliminate adhesions, helps with ovarian cysts, and is also effective for endometriosis. There are responses that narrate that after the treatment of gynecological ailments with Longidaza, pregnancy finally came. Men also respond positively to Longidase in the treatment of prostatitis. Especially note the absence of negative reactions and the convenience of its use.
As disadvantages, some patients indicate an unpleasant smell of candles, and when injected, they speak of pain at the injection site.