"Divigel" is a drug with anti-climacteric effect. This drug is part of the estrogen-based medication group and has a feminizing effect on the female body. The medication helps to normalize metabolic processes in the body, helps to improve the sexual function of women and increases the production of hormones in case of their deficiency. Against the background of postmenopause, the drug prevents the appearance of osteoporosis. Reviews about the "Divigel" are available in large numbers.
Indications
The drug is made in the form of a gel for external use. The content of the main substance of estradiol per 1 gram of the product is 500 mg. The medication is prescribed in the following cases:
- Hormone replacement therapy to eliminate estrogen deficiency in women.
- Treatment of menopausal syndrome that has arisen against the background of age-related or artificial menopause. Reviews about "Divigel" with menopause are mostly positive, they will be considered at the end of the article.
- When planning a pregnancy to make up for estrogen deficiency. According to reviews, Divigel is absolutely safe when planning a conception.
Contraindications
The medication is contraindicated for appointment in the following cases:
- Sickle cell anemia.
- Endometrial hyperplasia.
- Neoplasm in the pituitary gland.
- Diabetes.
- Congenital type hyperbilirubinemia.
- Angiopathy.
- Retinopathy
- Pathologies of connective tissues of a diffuse type.
- Oncological disease of the liver.
- Thrombophlebitis in the anamnesis.
- Hemorrhagic syndrome of the vagina of unknown nature.
- Tendency to uterine hemorrhagic syndrome.
- Menopause in the hyperestrogenic stage.
- Impaired fat metabolism.
- Oncopathology of the mammary gland.
- Spontaneous venous diseases of thromboembolic type.
- Tumors of the ovaries, uterus, endometrium, characterized as estrogen-dependent and malignant.
- Hypersensitivity to estradiol.
- Circulatory disorders in the brain, including ischemic or hemorrhagic type stroke.
- The inflammatory process in the organs of the female reproductive system, salpingoophoritis and endometritis.
- Otosclerosis.
- Deep vein thrombosis, as well as pulmonary embolism.
- Neoplasms in the organs of the reproductive system of women under the age of 60 years.
- Jaundice of cholestatic type.
Feedback on the use of Divigel will be presented at the end of the article.
Carefully
The use of the drug under careful medical supervision should occur with the following pathological processes and diseases:
- Migraine.
- Kidney or liver failure.
- Epileptic syndrome.
- Puffiness.
- Endometriosis.
- Heart failure.
- Mastopathy fibrocystic type.
- Porphyria.
- Asthma of a bronchial type.
- Arterial hypertension.
- Coronary heart disease.
It is not recommended to apply the gel on the genitals and mammary glands, as well as on such sensitive areas of the skin as the face.
You should familiarize yourself with the reviews about Divigel when planning your pregnancy in advance. This will help to adjust the course of therapy and avoid negative consequences.
Instruction manual
The use of the drug involves long courses of treatment with several repetitions.
It is applied once a day to cleaned and dried skin in the region of the lower anterior abdominal wall, as well as to the shoulders, the region of the lower back, forearm and buttocks, alternately. It is recommended to alternate places of application of gel every day. Do not apply on irritated skin. The gel coating area of the skin should not be more than 1-2 palms. After applying Divigel, you must wait a few minutes until the substance is completely absorbed. Watering the place of application is not recommended for one hour. Do not allow the product to get into the eyes, so after using the drug, you need to wash your hands thoroughly with soap.
Initial daily dosage
The initial daily dosage of Divigel is 1 mg of estradiol. However, the dosage may be adjusted depending on the intensity of the manifestation of unpleasant symptoms. The maximum dose of estradiol per day is 1.5 mg, which corresponds to 1.5 grams of gel. This increases the frequency of use of the product up to 2-3 times.
In the treatment of postmenopausal symptoms, a minimum dosage with therapeutic efficacy is used. The duration of use is determined by the doctor.
Divigel is used without progestogen only in patients who have had a uterus removed. If the patient has an intact uterus, the medication is prescribed in combination with a gestagen, which is taken for at least two weeks during the menstrual cycle. After the end of taking gestagen, withdrawal bleeding occurs. If the bleeding is extraordinary or prolonged, you must consult a doctor. Women after a hysterectomy with endometriosis in the history of progestogen do not accept.
If a woman has not used hormonal drugs for replacement therapy or is switching from combined drugs to Divigel without a break, then gel treatment can be started at any convenient day. When switching to a gel with continuous sequential hormone replacement therapy, Divigel treatment should be started after the end of the previous course.
Admission skip
If you miss the next use of the drug, you must apply the drug as soon as possible. This must be done no more than 12 hours from the estimated time of application. In the event that more time has passed, therapy is interrupted until the next time. Irregular use of the gel can lead to undesirable consequences such as spotting vaginal discharge and breakthrough bleeding.
Adverse reactions
Against the background of hormone replacement therapy "Divigel", according to reviews, the following undesirable reactions may occur from all organs and systems of the female body:
- Heart and blood vessels: high pressure in the arteries, thrombophlebitis.
- Nervous system: pain in the head of a paroxysmal type, migraine, depression and mood swings, dizziness.
- Metabolism: accumulation of water and sodium salts in the body against the background of prolonged use of the drug, porphyria.
- Digestive system: nausea and vomiting, pain in the abdomen, resembling colic, impaired bile outflow, icteric cholestatic syndrome, bloating.
- Allergic reactions: rash and itching on the skin, contact-type dermatitis localized at the site of application of the gel, redness and irritation of the skin.
- Endocrine system: marked increase and tension of the mammary glands, overweight, increased likelihood of developing diabetes due to a decrease in tolerance to carbohydrates.
- Genital system: changes in libido, uterine bleeding, endometrial hyperplasia, malignant endometrial neoplasm in the form of carcinoma, ovarian sclerosis, when there is a replacement with connective tissues, a marked increase in leiomyoma.
In addition, the use of a medication can cause curvature of the ocular cornea, accompanied by visual impairment. Also, against the background of using the gel, vaginal candidiasis and melasma may appear.
Reviews about Divigel
Women who used it respond quite well about the effect of the drug. They note marked relief in menopausal symptoms. In addition, the drug is often prescribed for women who experience problems with conception. According to reviews, pregnancy with Divigel occurs very quickly.
It is especially effective for those women who have impaired estrogen production, due to which the follicles in the ovaries do not pass the maturation stage. The drug penetrates deep into the tissue and is converted into estrogen, due to which the growth of follicles is activated and the endometrial layer grows. If you follow all the instructions of the instructions and your doctor, ovulation will occur after one month of application of the gel.
Reviews about Divigel do not end there.
One of the advantages of a woman is called the convenience of its packaging. Thanks to a special tube, it turns out to dose the gel in the required amount. In addition, the tube does not transmit light rays, which makes it possible to protect the hormonal substances contained in the preparation.
According to reviews, Divigel for the endometrium is the best medicine.
Another significant advantage of the drug for hormone replacement therapy is the lack of effect on the liver. It is this organ that is susceptible to the effects of tablet preparations, including those based on hormones. "Divigel" does not penetrate the liver and, accordingly, does not exert any effect on the organ, so it can be used even with hepatitis problems.
Negative comments
Criticism from women who used the gel concerns its adverse reactions. However, this is a consequence of taking any hormonal drugs. Nausea and dizziness accompany many women taking steroid pills. Gel in this case is no exception.