Allergic reactions bother many people. To get rid of such manifestations, doctors recommend the use of special anti-allergic drugs that significantly improve the patient's condition and eliminate all unpleasant symptoms.
In this article, we will tell you about how a medication such as Bekonase works. Instructions for using this local product will also be presented below.
Release form, composition, packaging
The Bekonase preparation, the instruction of which is enclosed in a cardboard box, is made in the form of a water spray for nasal use. The active component of this agent is beclomethasone dipropionate.
The drug goes on sale in bottles with a special dispenser.
Pharmacology of a local remedy
What is the spray "Bekonase", analogues of which are listed below? This medication is an intranasal form of a topical glucocorticoid that has anti-edematous, anti-inflammatory and anti-allergic properties.
Details on the properties of the drug
The antiallergic effect of the drug in question is due to its ability to suppress the receptivity of receptors to active biological substances (histamines, prostaglandins) and mechanical irritants. In other words, this drug has a direct effect on their non-specific hyperreactivity.
The drug helps to suppress mast cell degranulation, and also removes all active manifestations of inflammatory processes of an allergic nature. It also restores the sense of smell. It is this property that distinguishes the Bekonase medication (spray) from other anti-allergy drugs.
The agent in question improves mucociliary transport and does not affect neutrophils. In this regard, the drug does not change the immune response to a bacterial infection.
The anti-inflammatory properties of Bekonase are explained by its effect on cells by excitation of receptors that are responsible in DNA for transcription of target genes that regulate the synthesis of protein molecules involved in inflammation.
According to experts, this drug is able to inhibit the induction of nitric oxide synthesis, the activation of which has a pronounced pro-inflammatory effect. It also inhibits the synthesis of pro-inflammatory cytokines, which provoke the inflammatory process.
It should be noted that after application of the spray, the production of IgE and the formation of leukotrienes in the mucous membranes are blocked. The medication depresses the activity of genes that regulate the synthesis of enzymes and other protein molecules that are involved in the allergic process. As a result of this effect, tissue edema decreases and a decrease in the secretion of glands in the mucous membrane is observed.
Pharmacokinetics of the drug
Is Bekonase absorbed? The instruction reports that the medication is rapidly absorbed into the nasal mucosa. About 5% of the used dose enters the bloodstream. In this case, the drug is completely biotransformed at the first passage through the liver.
The very low bioavailability of this medication reduces the likelihood of unwanted effects to a minimum, even with prolonged use.
The drug comes into contact with albumin at 80-90%. Its half-life is 16 hours. The drug is eliminated through the kidneys and along with feces.
Indications
For what purpose are nasal drops prescribed to Bekonase? According to expert reviews, this drug is used in inflammatory processes of non-infectious genesis that occur in the nasal cavity. It is also used for relapses of nasal polyposis and allergic rhinitis (seasonal or year-round).
Contraindications
When should you not use Bekonase spray? Reviews of doctors report that this drug has a fairly large number of contraindications. It is not recommended for use with beclomethasone intolerance, as well as in conditions such as:
- glaucoma, a history of myocardial infarction, pathology of the renal system;
- amoebiasis, herpes of the mucous membranes of the eyes;
- pulmonary tuberculosis, recent injuries and nose surgery;
- systemic infections of fungal or bacterial origin, hypothyroidism, ulceration of the nasal septum;
- breastfeeding, pregnancy.
The drug "Bekonase": instructions
The medication in question is prescribed only for intranasal use. In the children's age group of 6 years, as well as adults, the drug is recommended to be used in the amount of one dose in each half of the nasal cavity. Perform instillation should be three or four times a day. If a double dose of the drug is used, then it is injected twice a day.
As practice shows, the therapeutic effect after applying the spray is noted after 5-7 days.
Side effects
The medicine "Bekonase", the price of which is indicated below, is absolutely safe for adult children, even with prolonged use. Its systemic adverse reactions are minor.
In rare cases, the medication can cause local adverse reactions in the form of sneezing, burning and dryness of the nasal mucosa, as well as bleeding and relapses of herpes infection. In addition, in isolated cases, perforation of the septum of the nose was noted .
In the presence of hypersensitivity, the patient may manifest such allergic reactions as urticaria and skin rash.
Spray "Bekonase": analogues and cost
If necessary, the drug "Bekonase" can be replaced by such similar means as "Agistam", "Equazolin", "Otrivin", "Marimer", "Camphomen", "Physiomer".
Buying the drug "Bekonase" in the form of a spray will not be difficult, since it is sold in almost all pharmacies without a doctor's prescription. Its cost varies from 800-950 rubles.
Reviews about the drug
Reviews of patients about the drug under consideration for topical use are very mixed. Someone claims that he copes quite effectively with the task and eliminates all signs of allergic rhinitis, as well as inflammatory processes in the nasal cavity of non-infectious origin.
However, there is such a category of people who report that this drug is absolutely useless. Moreover, a large number of patients are quite confused by the cost of this medication. Although experts say that its price is fully consistent with the quality.
The only positive aspect of this remedy, which absolutely all patients talk about, is that it very rarely causes side effects.