The drug "Ondansetron" describes the instructions for use as an
antiemetic, effectively suppressing the
emetic reflex, preventing and eliminating nausea. The basis of the action of this medication is competitive highly selective blockade of peripheral and central receptors
serotonin. This antiemetic drug demonstrates the highest efficiency in the
postoperative period, as well as during radiation therapy and special chemotherapeutic drugs. However, in this case, it should be emphasized that the frequent use of the Ondansetron medication (the instructions for use confirm this) can significantly slow down intestinal motility and the passage of contents through the gastrointestinal tract. As for its pharmacokinetic parameters, the highest plasma concentrations are observed one and a half to two hours after direct use, and the half-life takes about three hours.
The Ondansetron drug is produced (instructions for use are always included) in the form of yellow oval tablets and in the form of a solution for infusion and injection. The first as the main element includes ondansetron hydrochloride dihydrate in the amount of five or ten milligrams. Additional components in this case are anhydrous lactose, magnesium stearate, pregelatinized starch, microcrystalline cellulose and yellow opadria. The composition of a colorless transparent solution contains four or eight milligrams of ondansetron as an active element. Auxiliary ingredients are citric acid monohydrate, sodium dihydrate citrate, nitrogen, sodium chloride and purified water.
The use of the drug “Ondansetron” recommends the use of the drug in order to eliminate and prevent vomiting and nausea in patients undergoing cytotoxic chemotherapy. In addition, the use of this drug is very effective in the postoperative period.
During radiation therapy, it is also worth using the ondansetron antiemetic . Reviews at the same time indicate good results of its use both with daily irradiation of the abdominal area, and with a single, but with high doses.
The manufacturer categorically prohibits prescribing this antiemetic drug in case the patient has an allergic reaction to Ondansetron or is individually intolerant of any of the components present in its composition. During the period of bearing a child (especially during the first three months), Ondansetron medicine should also not be taken. These tablets should not be prescribed to younger patients and women who are breastfeeding. In addition, serious contraindications to liver function and surgical interventions in the abdominal cavity are direct contraindications for use.