The trade name for trimeperidine is Promedol. The generic international name for the drug is Trimeperidine. The medication is made in the form of tablets (in a package of ten or twenty pieces), as well as in the form of an injection solution of a concentration of 1 or 2% in ampoules.
The pharmacological group of trimeperidine is opioid analgesics.
The composition of the drug
One milliliter of the drug solution contains 0.01 or 0.02 grams of promedol. An additional substance is injectable water, a narcotic, analgesic.
One tablet contains twenty-five milligrams of the active ingredient.
A Latin recipe for trimeperidine will be presented at the end of the article.
Indications for use
The drug is used for children and adults as an anesthetic for pains of moderate and low intensity, which are primarily caused by injuries, during the operation, before and after it, with myocardial infarction and severe angina attacks.
The drug is effective for pain caused by spasm of smooth muscles of internal organs (in combination with antispasmodic drugs and atropine-like), pain in malignant tumors, including chronic pain.
In the practice of obstetricians, Promedol is used to anesthetize during childbirth - it does not have an undesirable effect on the fetus if the dosage is normal.
The drug "Promedol", the trade name for trimeperidine, is known to many.
Method of application and quantity
The instruction for use involves delivering it to the human body using subcutaneous, intramuscular and, in critical cases, intravenous injections in the form of a solution, as well as oral (internal) administration in tablet form.
To stop the pain, it is recommended to drink tablets orally in an amount of 25-50 milligrams for adult patients. The maximum dose during the day in tablets is 50 milligrams.
For adults, as a rule, intramuscular and subcutaneous injections are prescribed in a dosage of 10-40 milligrams (from one ampoule of a solution of 1% to two ampoules of a solution of 2%).
When carrying out anesthesia, it is advisable to inject fractionally intravenously, from three to ten milligrams, depending on the situation.
In case of pain due to spasms of smooth muscles, the drug is prescribed along with atropine-like and antispasmodic drugs, the patient's condition is carefully monitored.
For premedication, half an hour before surgery, 20 to 30 milligrams are administered subcutaneously or intramuscularly in combination with Atropine (half a milligram).
During childbirth, Promedol is prescribed to stimulate activity and anesthesia. Injections are made subcutaneously and intramuscularly from 20 to 40 milligrams, with a positive state of the baby and the opening of the uterine neck by 3-4 centimeters. The drug relaxes the muscles of the uterine neck and thereby accelerates its opening. Half an hour or an hour before a possible delivery, the last injection should be made so that there are no negative consequences for the respiratory activity of the child.
The maximum amount of parenteral administration to adult patients is 40 milligrams, during the day - 160.
For children after two years, the dosage is 0.1-0.5 milligrams per kilogram of weight, with subcutaneous, intramuscular and rarely intravenous administration. After 4-6 hours, repeated injections can be performed to relieve pain.
For general anesthesia, Promedol is administered intravenously from 0.5 to 2.0 mg / kg / hour. Throughout the duration of the operation, the maximum dose should be no more than two milligrams.
It is advisable to infuse from ten to fifty mcg / kg / hour.
Epidural anesthesia is carried out in an amount of 0.1-0.15 milligrams per kilogram, "Promedol" is previously diluted in an injection solution of sodium chloride (from 2 to 4 milligrams). The onset of the effect is noticeable after 15-20 minutes, the climax - after 40 minutes, the effectiveness gradually decreases over eight hours or more.
How is Latin trimeperidine indicated in the recipe? About it below.
Drug overdose
If an overdose or poisoning occurs, a coma or stuporous state develops, breathing is inhibited. A distinctive symptom is a clear narrowing of the pupils (pupils with severe hypoxia can be dilated).
Maintaining proper ventilation is the first aid. Intravenous administration of a specific opioid naloxone antagonist (Narcan, Intrenon, Narcanti) in an amount of 0.4-2.0 milligrams promotes rapid recovery of respiration. If there is no effect, after 2-3 minutes, the administration of naloxone is repeated. The initial dose of the latter in childhood is 0.01 milligrams per kilogram. You can use "Nalorphine" - from 5 to 10 milligrams intravenously or intramuscularly every fifteen minutes until a total dosage of 40 milligrams is reached. It is necessary to take into account the possibility of withdrawal syndrome if these drugs are administered to patients with addiction to promedol or morphine - the doses of antagonists in such situations should be gradually increased.
Contraindications
Explicit contraindications for the use of the medication:
- If the patient has a condition that is accompanied by respiratory depression.
- The drug is carefully administered to patients with a history of dependence on opioids.
Next, consider analogues of trimeperidine (trade name "Promedol").
Analogs
Promedol has no generics, that is, drugs with the same active ingredient (trimeperidine).
Analogs that have a similar effect and are included in the same pharmacological group are:
- “Omnopon”: active ingredients - codeine, morphine, narcotine, papaverine, thebaine.
- "Morphine" is an injection solution of 1%, the active substance is morphine hydrochloride. You can buy only the "red" recipe.
- "Tramal" - the active substance is tramadol.
Reviews
All opioid drugs are dangerous for the body getting used to the effects of the drug and overdose. This applies to trimeperidine with the trade name "Promedol".
But it is precisely his effective analgesic effect that receives the positive feedback from patients. Promedol helps patients with severe, excruciating pain (especially when it comes to children).
They respond positively to the preparation of the woman in childbirth, childbirth thanks to him passed almost without pain, but actively, since he stimulated activity gently. In addition, relaxation of the cervix prevents alleged tearing of muscles and tissues.
However, there are significant side effects: addiction, respiratory depression, CNS suppression. This is a powerful drug.
The prescription for trimeperidine is written on the prescription form. Its sample is presented below.
Latin Recipe
Rp: Sol. Promedoli 1% 1ml Dtd: No. 10 inamp. S: For insertion under the skin.
Rp: Sol. Promedoli 2% -1 ml Dtd No. 10 in amp. S .: 1 ml IM with the goal of anesthetizing labor at the end of the latent phase of the first period.
We examined the trade name of trimeperidine and its use.