Antibiotics are substances of semisynthetic or natural origin. They help to suppress the growth of living cells (mainly protozoa or prokaryotic). Such drugs can be used for various diseases.
The most commonly used antibiotic is Linkomycin. Reviews, the properties of this medication and methods of its use are presented below.
Form, composition
What forms are inherent in the drug "Linkomycin"? Reviews of experts say that this drug is available in various forms. In pharmacies, it can be found in the form of capsules, tablets, ointments and injection.
The composition of such an antibiotic includes the main component in the form of lincomycin and various auxiliary substances.
Pharmacological characteristics
What is the drug "Linkomycin"? Reviews (tablets and other forms of this medicine should be prescribed only by an experienced doctor) report that this is an antimicrobial agent that belongs to the group of lincosamides. It has a bacteriostatic effect in relation to a wide range of bacteria. When using higher doses of the drug, it can exhibit bactericidal properties.
Mechanism of action
How does Lincomycin (injections) work? Reviews indicate the following mechanism of the antimicrobial effect of this antibiotic: after its use in the cells of microorganisms, protein synthesis is inhibited. It should also be noted that this medication has a pronounced activity against gram-positive anaerobes and aerobic bacteria.
One cannot fail to say that fungi, viruses, protozoa, and Enterococcus faecalis strains demonstrate high resistance to the influence of this drug . Gram-negative microorganisms are also resistant to the drug in question.
Resistance to this tool develops very slowly.
Kinetic features
What kinetic properties are inherent in the antibiotic "Linkomycin"? Reviews claim that after ingestion, the active substance is rapidly absorbed from the digestive tract. Approximately 50% of lincomycin enters the systemic circulation. The drug binds to plasma proteins by 75%, and its peak concentration is observed after 2-4 hours.
This drug penetrates all tissues and fluids. The highest concentrations of this medicine are observed in the kidneys, saliva, liver, genitals, heart muscle, bronchial secretion and bone tissue.
Also, the medication in question is able to penetrate the blood-brain barrier and excreted along with breast milk.
The metabolism of this medicine occurs in the liver. It leaves the patient's body with feces and urine. The half-life of the drug is 5-7 hours.
Indications
For what purpose is Lincomycin used in dentistry? Reviews report that this drug is used to treat infectious and purulent processes in the oral cavity. In particular, the medication in question is prescribed for the treatment of periodontitis, gingivitis, periodontitis, purulent abscesses, etc.
Lincomycin tablets, capsules and injections are used in the following cases:
- with infectious diseases of the respiratory tract and ENT organs provoked by sensitive bacteria (with tonsillitis, otitis media, sinusitis, pneumonia, bronchitis, tracheitis, etc.);
- with diseases of the joints and bones of an infectious nature that were provoked by microorganisms sensitive to the drug (for example, septic arthritis, osteomyelitis);
- with diseases of soft tissues and skin (for example, with an abscess, purulent wounds, mastitis, furunculosis, erysipelas, etc.).
Why is the external drug “Lincomycin” (ointment) prescribed? Reviews claim that such a medication is used for purulent and inflammatory diseases of the skin and soft tissues.
Contraindications
The drug in question cannot be prescribed with high sensitivity to antibiotics, which belong to the group of lincosamides. Also, it is not used to treat people suffering from severe liver and kidney diseases, and under the age of 6 years.
The use of the drug "Linkomycin"
Reviews say that only a doctor should prescribe this medicine. The drug in the form of a solution is administered intramuscularly or intravenously. Its maximum daily dosage is 1.8 g.
Lincomycin capsules and tablets are recommended to be taken 1 hour before meals.
When using the drug in dentistry and in the treatment of other infectious diseases, the drug is prescribed 500 mg three times a day. With more severe symptoms, the dosage can be increased up to 4 times a day.
Lincomycin ointment is used externally. Its thin layers are applied to the lesion site twice or thrice a day.
Side effects
When using the drug "Linkomycin" in ampoules and capsules in humans, the following phenomena may occur:
- violation of the hematopoiesis process (pancytopenia, agranulocytosis, thrombocytopenia, neutropenia);
- gastrointestinal disorders (esophagitis, vomiting, increased activity of liver enzymes, abdominal pain, stool disorders, nausea, hyperbilirubinemia);
- allergies (skin itching, erythema multiforme, urticaria, edema, rash, anaphylactic shock);
- headaches, muscle weakness, dizziness, arterial hypertension.
Reviews
According to patient reviews, the medication in question has a pronounced antimicrobial effect. It allows you to quickly eliminate the unpleasant symptoms of infectious diseases.
Also, some consumers argue that with intravenous or intramuscular administration, this drug acts much faster.
Reviews of patients about the use of this medicine in dentistry report that it quickly helped them get rid of inflammatory and purulent diseases.