Mildronate is an effective drug that has been successfully used in modern medical practice for the treatment of cardiovascular diseases.
Before you start taking this medication, it is important to study the instructions for it. This drug is distinguished by a number of indications and contraindications, which the doctor must take into account when prescribing treatment. Many are interested in the best manufacturer Mildronat. There are several countries where it is released. Consider the instructions for using this drug.
Structure
The main active substance of Mildronate is meldonium - an analogue of gamma-butyrobetaine, produced by the cells of the body.
In tablets, there are excipients:
- Potato starch.
- Silicon dioxide colloidal.
- Calcium stearate.
The shell of the tablets consists of titanium dioxide and gelatin.
In ampoules for injection contain meldonium (100 mg per 1 ml) and water.
Meldonium properties
This substance has a positive effect on myocardial contraction, it has a myocardioprotective effect, can prevent heart rhythm disturbances, thereby reducing the infarction zone. Analysis of information on the use of Mildronate for the treatment of angina pectoris shows that the drug effectively reduces the amount of glyceryl trinitrate and the intensity of angina attacks.
This substance has a persistent antiarrhythmic effect on patients with ventricular extrasystoles and ischemic heart disease, and in people with supraventricular extrasystoles, a not so intense effect is noted. Of vital importance is the ability of Mildronate to reduce oxygen consumption by cells during antianginal therapy, when CHD is detected.
Meldonium has a positive effect on arising atherosclerosis, which can occur in peripheral and coronary vessels, thereby reducing the atherogenic index and cholesterol level in blood plasma
In the experiments, the antihypoxic effect of the active substance was revealed, as well as the action aimed at improving cerebral circulation. Mildronate has a stimulating effect on the nervous system - it increases endurance and activity, stimulates the improvement of behavioral reactions, can have an anti-stress effect and protect organs from stress changes.
Exposure
"Mildronate" is a fairly well-known and widely used drug, which is usually prescribed by neurologists and cardiologists. It belongs to the category of metabolic agents, having the following effects:
- Antihypoxic - the drug prevents hypoxic tissue damage.
- Angioprotective - strengthening the walls of the capillaries, improving microcirculation, as well as increasing their tone.
- Cardioprotective - Mildronate has a beneficial effect on the myocardial metabolism.
- Antianginal - normalization of the functioning of the coronary vessels, facilitating the delivery of oxygen to the muscles of the heart system.
Indications for use
Mildronate is prescribed as a tread preparation. Use this medication strictly as prescribed by the doctor, because otherwise there is a likelihood of the patient developing a variety of negative effects.
Indications for use:
- VSD.
- Bronchitis.
- Circulatory disorders in the meninges.
- Dyshormonal cardiomyopathy.
- Withdrawal syndrome.
- Performance degradation.
- Excessive mental stress, physical strain.
- Hemophthalmus.
- Heart failure.
- Speeding up the recovery process after the operation.
- Asthma.
- For weight loss.
Contraindications
Despite the effective effect of Mildronate, there are some circumstances in which it is not worth using. So, the drug is not recommended for use in such situations:
- Pregnancy.
- High ICP.
- Breast-feeding.
- Allergy to the components of Mildronate.
- Age to 12 years.
Negative actions
Usually, Mildronate is tolerated without much difficulty, but it is worth remembering that it can cause some side effects:
- Sudden pressure surges.
- Tachycardia.
- Loss of consciousness.
- An allergic reaction (rashes (urticaria), swelling, itching, allergic-type rhinitis, and redness).
- Shortness of breath.
- Symptoms of dyspepsia.
- Quincke's edema (damage to the eyes, face, lips and larynx).
- An increase in the number of eosinophils.
- Psychomotor agitation.
- Anaphylactic shock (difficulty breathing, loose stools, vomiting, blueness of the skin, impaired functioning of certain organs).
- General weakness.
Admission Rules
Capsules should be taken without chewing. Biting or breaking the integrity of the capsule is prohibited. Mildronate should be washed down with plenty of water. Often this drug is prescribed for athletes, as it will protect the heart from high loads and stresses.
Injection solution
Injections are predominantly performed intramuscularly, parabulbarly, and also intravenously. With intramuscular injection, Mildronate will enter directly into the thickness of the muscle system, after which it is delivered to the cells. Injections of the parabulbar type suggest the introduction of the drug into the eye area (through the lower eyelid to the edge of the eyeball).
The solution for the preparation of injections is released in ampoules. They must be opened immediately before injections.
Before applying this tool, the solution must be inspected for the absence of sediment. For injections it is allowed to use an exceptionally clean solution. Intramuscular injections are allowed even at home, and parabulbar and intravenous injections are performed only in a hospital.
Drops
Typically, the agent in the form of drops is used in ophthalmology in such situations:
- Retinal hemorrhage.
- Identification of non-inflammatory lesions of the retina.
- Thrombosis developing in the main vein.
- Pathology of the optic nerve.
Syrup
This form of the drug is prescribed mainly to children over 12 years old. The tool is prescribed by cardiologists when diagnosing disorders in the functioning of the heart. "Mildronate" is allowed to use with reduced performance and excessive exhaustion, for example, during exams.
Dosage
The duration of treatment largely depends on the diagnosis. But this drug will provoke the occurrence of psychomotor agitation, so it must be consumed in the morning.
One tablet of Mildronate contains 250 or 500 mg of the active substance. 5 ml of syrup includes 250 mg of meldonium. The course of therapy, as well as the dosage, depends on the disease and the condition of the patient. Assigned to 500 or 1000 mg per day. You can use this amount at a time or divide it into two doses.
With cardialgia, 500 mg of meldonium is prescribed per day.
In case of circulatory disturbance of the brain - 500-1000 mg per day.
In the case of using Mildronate in the form of syrup and capsules, you need to use it 30 minutes before eating. The last dose of medicine must be taken before 17:00 to facilitate the process of falling asleep.
Course duration
It is extremely undesirable to use this tool for self-treatment. It is very important that the duration of treatment and the dosage of the drug should be prescribed by the doctor who will tell you the Mildronate regimen without interruption and harm to health. Appointments must be made strictly individually.
To achieve the desired effect, you should adhere to the following recommendations when taking the drug:
- For diseases in a chronic form, treatment should be prescribed individually, but its duration is usually not more than 1.5 months;
- With pathology in acute form, the drug should be consumed for 4-6 weeks.
If necessary, the course is recommended to be repeated after a break.
Drug interaction
"Mildronate" without complications combined with such medications:
- Diuretic drugs.
- Antiplatelet agents.
- Bronchodilators.
- Antiarrhythmic drugs.
Mildronate may enhance the effects of other medicines. Usually, this condition is noted with the combined use of this medication with:
- Drugs that help lower blood pressure.
- Cardiac Glycosides.
- Beta-blockers.
Analogs
Many drugs are known to have the same effect as Mildronate. These are: Bravadin, Dibikor, Melfor, Predizin, Riboxin, Carditrim, Kudesan, Medatern, Ethoxidol and Trimet. The solution has the following analogues: Inosin-Eskom, Mexicor, Cardionate, Idrinol, Firazir, Phosphaden, and Histochrome.
Pregnancy and feeding a baby
The safety of using Mildronate during the gestation of a child is not exactly established. To avoid possible adverse effects on the fetus, it should not be used during lactation and in the process of gestation.
It is also unknown whether the active substance "Mildronate" with mother's milk will be excreted. If there is a need to use the drug while breastfeeding, it is recommended to stop lactation.
Application features
Patients suffering from certain chronic diseases should be extremely careful when using the drug. This applies to patients suffering from renal and liver failure. There is no accurate data on its effect on the ability to drive vehicles.
Manufacturers
There are practically no reviews about the manufacturer "Mildronata". Latvia is the country where this medicine is produced. Patients in their reviews do not focus on this. In addition, Mildronat is produced in Poland (Elfa Pharmaceuticals company in Jelenia Gora) and in Slovakia (HPM Pharma company). Regardless of the manufacturer of Mildronate, Germany actively uses this medicine to treat patients suffering from cardiovascular diseases.
In our country, this medication is not produced. We have indicated above who is the manufacturer of Mildronate. In Russia, its analogues are produced. They are no less effective, but cheaper. These are: "Melfor", "Meldonium", "Cardionate", "Idrinol". In Belarus, analogues of the drug in question are also produced. These are: Mildrocard and Riboxin.
Patient opinions
People in their reviews report that Mildronate helps to solve many problems with the heart, blood circulation, relieves fatigue, and increases activity. Students report that taking this medication helped them prepare for the session. Athletes also speak well of the drug. Many write that he has practically no adverse reactions.
However, there are people who have not experienced the effects of Mildronate. They report that after a course of treatment with this remedy they did not increase strength, and fatigue did not decrease.
Total
Mildronate is widely used in various conditions of patients. This drug is produced in different countries. Which manufacturer of Mildronate is better? According to reviews, this is the Latvian company Santonika. The owner of the registration certificate "Grindeks" (Riga). Also, Russian pharmaceutical companies that produce effective and inexpensive analogues have proven themselves well. The drug is prescribed for decreased performance, physical stress, heart failure. If you apply it strictly as prescribed by your doctor, no unwanted reactions are observed.