Hepatoprotectors are drugs that positively affect the liver. Also, this group includes agents that are able to protect the cells of the said organ from any damage. However, it should be noted that the effectiveness of a large number of hepatoprotectors has not been confirmed by clinical trials.
The most popular remedy with such properties is the drug "Darsil." Instructions for use of the drug will be presented below. You will also find out what reviews about this medicine leave patients, what properties are inherent in it and so on.
Composition, form and packaging of the drug
The drug "Darsil", the instruction of which is enclosed in a cardboard package, contains such an active compound as silymarin. In addition to it, the preparation contains excipients in the form of potato starch, sugar, lactose monohydrate, calcium stearate, titanium dioxide, magnesium carbonate, talc, aerosil, silicon dioxide, low molecular weight polyvinylpyrrolidone, wax and dye.
On sale, this tool comes in the form of round tablets. They are coated and packaged in contour cells.
Pharmacodynamic properties
What is the drug "Darsil"? Instructions for use of the drug reports that it belongs to herbal remedies. The complex of flavonoid compounds that make up the drug neutralizes the negative effects of free radicals in the liver, exerting a hepatoprotective effect (stabilizes the membranes of hepatocytes and prevents the destruction of cell structures).
It should also be said that this tool stimulates the synthesis of functional proteins and phospholipids that are in damaged hepatocytes, prevents the release of transaminases, activates RNA polymerase and accelerates the regeneration of liver cells.
The active substance of the drug slows the penetration of certain poisons and toxins into the hepatocytes, including the poison of the toadstool. In addition, silymarin blocks the production of acetaldehyde.
After taking Darsil, patients have a decrease in weakness and a feeling of heaviness under the right rib. In addition, treatment with this agent helps to normalize blood biochemical parameters and improve the general condition of a person.
Drug kinetics
Where is the drug "Darsil" absorbed? Instructions for use indicate that the absorption of this drug occurs in the digestive tract.
In the systemic circulation, this drug does not bind to plasma proteins. Moreover, it does not cumulate in the body.
The metabolism of the drug is carried out in the liver. The drug is excreted along with bile for 6 hours.
Indications for taking pills
What diseases does the Darsil medication treat? Instructions for use, reviews of specialists indicate that this tool is very effective in:
- acute and chronic hepatitis of various origins (including viral), as well as posthepatic conditions;
- cirrhosis and fatty liver;
- toxic liver damage (for example, poisoning with salts of heavy metals, medicines, pesticides, alcohol and mushrooms).
Contraindications
The Darsil medication, the instruction of which will be presented below, cannot be taken with hypersensitivity to the drug, as well as under the age of 5 years, with peptic ulcer and erosive diseases of the digestive tract (especially during exacerbation), during breastfeeding and pregnancy, with lactase deficiency and galactose intolerance.
With extreme caution, this medicine is recommended for diabetes mellitus and various hormonal disorders, for carcinoma of the ovary, uterus, prostate and breast, uterine fibroids, endometriosis.
The drug "Darsil": instructions for use
Reviews of experts say that the drug in question must be taken orally after a meal.
The recommended dosage for adolescents from 12 years of age and adults is 1-2 tablets three times a day.
For babies 5-12 years old, the daily dose is divided into 2-3 doses and is calculated according to the following scheme: 3 mg / kg of weight.
The duration of this drug is determined individually (depending on the type and severity of the disease). On average, take a medication for about three months.
Side effects
Darsil tablets, the instructions for which were described in detail above, are well tolerated by patients. Sometimes, while taking this medication, the following side effects are noted:
- arthralgia;
- dizziness, shortness of breath;
- headache;
- heartburn, increased diuresis;
- vomiting, flatulence, nausea, diarrhea;
- local allergic manifestations (alopecia, rash and itching on the skin).
After discontinuation of the drug, these symptoms completely disappear.
Drug interaction
Can Darsil be combined with other medicines? The instruction reports that this medicine enhances the effect of hypocholesterolemic, antiallergic, antipsychotic and a number of antitumor drugs, as well as anticoagulants and antifungal agents.
It is impossible not to say that silymarin significantly reduces the effectiveness of oral contraceptives and medicines for estrogen replacement therapy.
Price, analogues
How much is the drug "Darsil" (tablets)? The instruction will not give an answer to this question. You can find out the cost of the medicine at the pharmacy. As a rule, it is 190-200 rubles.
You can replace the medication in question with such means as Karsil, Hepaleks, Legalon, Karsil forte, Heparsil, Silimar, Gipoglisil.
Reviews
Most reviews of the drug "Darsil" are positive. Consumers claim that taking this medication helps to reduce pain and discomfort in the right hypochondrium. Moreover, the hepataprotector in question eliminates all the consequences that are caused in the process of impaired liver function.
Also, the advantages of this medicine include its low cost, availability and the absence of adverse reactions.