Why is a medicine like Rosex Cream needed? You will definitely find the answer to this question in the materials of the presented article. In addition, we will tell you about the pharmacological characteristics of this drug, what is included in its composition and how it should be used correctly.
Cream "Rosex": the composition of the drug and its packaging
Before using this drug, you need to find out what composition it has. According to the attached instructions, this medication includes such an active component as metronidazole. In addition, this preparation for external use also contains auxiliary elements such as glycerol, benzyl alcohol, non-crystalline sorbitol 70%, isopropyl palmitate, purified water, sodium hydroxide, emulsion wax and lactic acid. Sometimes by mistake 0.75% Rosex cream is mistaken for ointment. This drug goes on sale in plastic tubes of 15, 5, 50 or 30 g.
In addition to cream, this tool is available in the form of a gel.
Pharmacological properties of the drug
What is the drug "Rosex" (cream)? The instructions for the use of the medication say that it is an excellent anti-acne remedy. It should be especially noted that the mechanism of action of this drug is not exactly known. However, experts say that its active component in the form of metronidazole has increased antioxidant activity.
It has been established that this agent significantly reduces the production of active oxygen, as well as hydrogen peroxide and hydroxyl radicals, which are potential oxidants that can cause tissue damage at the site of the inflammatory process.
What other properties does Rosex cream have? The instruction for use of this external preparation states that its active component in the form of metronidazole is ineffective against telangiectasias, which are noted with acne rosacea. Aerobic microorganisms are also resistant to this element.
Thus, the medication in question is an antiprotozoal agent. Experts believe that the principle of its action is directly related to the violation of the DNA structure of bacteria sensitive to the agent.
Pharmacokinetics
The bioavailability of this drug (oral) is about 80%. After using the medication, it is rapidly distributed in body fluids and tissues. Metronidazole penetrates well through the BBB and the placental barrier.
Communication with plasma proteins is about 20%. The metabolism of the drug passes in the liver through binding to glucuronic acid and oxidation. The medicine is removed along with urine (about 60-80%) and feces (about 6-15%).
With local use of the drug (cream, gel), its systemic effect is minimal. The maximum concentration of the active component in blood serum with external use of the drug (when applied to the skin of the face) is about 33 ng / ml. It should be noted that this amount of medication does not exceed 1 percent of the concentration (maximum) of metronidazole in serum after taking the drug (in the form of tablets) inside in a volume of 250 mg.
The peak concentration of the active component in blood serum after cutaneous use is observed after about 7-25 hours.
With external application, the concentration of the drug at the place of use is significantly higher than in the blood plasma.
In what cases are they used?
Now you know what “Rosex” cream is. What is this drug used for? According to the attached instructions, this medication is used for the following deviations:
- vulgar acne;
- pink acne, including poststeroid;
- skin diseases of an infectious nature;
- pressure sores;
- trophic ulcers;
- burns;
- eczema seborrheic;
- eczema;
- oily seborrhea;
- seborrheic dermatitis;
- sluggish wounds;
- trophic ulcers on the legs (against the background of diabetes mellitus or varicose veins);
- hemorrhoids;
- pressure sores;
- cracks in the anus.
These indications relate to the product for external use (cream, gel). As for the oral forms of metronidazole, they are prescribed for the following diseases:
- giardiasis;
- Trichomonas urethritis in representatives of the stronger sex;
- urethritis and Trichomonas vaginitis in women;
- amoebic dysentery;
- combined treatment of severe mixed aerobic and anaerobic infections;
- anaerobic infections caused by metronidazole-sensitive bacteria;
- prevention of anaerobic infection during surgical interventions (on the urinary tract and organs of the abdominal cavity).
In what cases is it forbidden to use the cream?
When should you not use Rosex cream? Contraindications to the use of this tool are listed in the attached instructions. According to her, this drug is forbidden to use with increased patient sensitivity to metronidazole, as well as during pregnancy (especially in the first trimester) and during lactation.
Methods of using the drug "Rosex" (cream)
For a person, this medication is prescribed only if the patient has acne. The drug is applied in a thin layer on previously cleansed skin. Do this twice a day (before bedtime and after morning awakening).
If necessary, Rosex cream is first applied to a gauze dressing, and then applied to the face or to another part of the body. In this form, the local preparation is kept for half an hour.
Rinse off the cream with water should not. You only need to get it wet with a paper towel. As a rule, the duration of treatment with this drug is 4-9 weeks. If necessary, the duration of therapy can be increased to 3-4 months, but only according to the recommendations of the attending physician.
It should be noted that the gel and cream "Rosex" can be alternated. However, it is recommended to do this with an interval of 8-11 hours.
As practice shows, the therapeutic effect after the use of the drug in question is noted after three weeks.
Are there any side effects?
It is no secret to anyone that almost all drugs (including local and external) have certain side effects. And the cream we are considering is not an exception to this.
According to patients' reviews, after regular use, this drug can contribute to the appearance of various allergic reactions (for example, urticaria and skin rash). In addition, Rosex cream often causes peeling, flushing, burning of the skin, as well as severe lacrimation.
In case of observation of at least one of the above side effects, the use of an external agent should be discontinued and consult a doctor. After the examination, the doctor must prescribe a similar, but safer drug to the patient.
Effect on the fetus
There have been no controlled clinical trials on the use of the drug during pregnancy and during breastfeeding. However, animal studies have shown that the drug for external use does not have a toxic effect on the fetus. In addition, it does not cause pathologies and other malformations. It should also be noted that the cream is not able to penetrate into breast milk.
The use of the drug during pregnancy and during the period of feeding the baby with breast milk is permissible only if the possible benefit to the mother significantly exceeds the probable risk to the fetus.
Special instructions for the use of an external agent
What you need to know before using Rolex external cream? Patient reviews about this drug will be described below.
This medication is intended exclusively for external use. During use of the cream, you must be careful not to get it on the mucous membranes. In this regard, the drug should not be applied to the face near the eyes. Otherwise, it can cause quite severe lacrimation.
If the medication nevertheless got on the mucous membrane of the visual organs, then the eyes should be immediately rinsed with a large volume of warm water.
It is impossible not to say that it is extremely important to apply the gel or Rosex cream to the entire affected area.
The active substance of this drug (metronidazole) is water-based. Moreover, this medicine does not contain fats. In this regard, he is absolutely not visible on the face, and also does not leave any spots.
Interaction with other means
Can I use this cream for external use in conjunction with other drugs? According to experts, with the simultaneous use of Rosex cream with the medication Warfarin and other indirect anticoagulants, the effect of the latter is enhanced, and prothrombin time is also increased .
Analogues of means and its price
Now you know why Rosex Cream is needed (the description of the drug was presented above). You can buy this medication in the amount of 30 g for 450 Russian rubles. If necessary, the external agent is replaced by its analogues. The following medicines are especially popular among them: Aquametro, Arilin, Deflamon, Kamezol, Medazol, Metrogil, Metroksan, Metron, Metronidazole, Nidazole, Orvagil "," Rosamet "," Trichobrol "," Trichopolum "," Flagil "and so on.
Reviews about the drug
What do patients say about such an external agent as Rosex cream? Reviews about this medication are only positive. Most patients who used the drug to treat acne report that after regular use of the cream, they completely got rid of unwanted sores on the face.