Why is Metamax in ampoules needed? Instructions for use and indications for taking this drug will be described in the materials of this article. From it you will also learn about what other forms of release this medication has, what is included in its composition, how to use it correctly and how much it costs.
Packaging, composition, form and description
What substances does the drug “Metamax” contain in ampoules? Instructions for use state that a clear, odorless solution for injection includes an active component such as 3- (2,2,2-trimethylhydrazinium) propionate dihydrate. The medication also contains an auxiliary substance in the form of purified water.
In what packaging is the drug “Metamax” in ampoules sold? Instructions for use indicate that this drug with a volume of 5 ml is placed in contour packs, which, in turn, are in packs of cardboard (10 ampoules each).
It should also be noted that the funds in question have another form of release. Metamax white capsules, the price of which is quite high, contain the same active substance as the solution for injection. As for the auxiliary components, they include potato starch, anhydrous colloidal silicon dioxide and magnesium stearate.
The medicine goes on sale in contour packs (10 capsules each), which are in cardboard packs.
Pharmacological properties
The description of the drug "Metamax" contains information that it has an angioprotective effect. This medication is a synthetic analog of butyrobetaine, which inhibits the enzyme hydroxylase.
The drug in question can reduce the synthesis of carnitine, as well as reduce the accumulation in the tissues and cells of derivatives of acylcarnitine and acylcoenzyme A.
It cannot be said that this agent improves ATP transport, activates glycolysis, and restores the balance between transport and oxygen consumption by cells located in ischemic zones.
Pharmacodynamic and pharmacokinetic characteristics
What are the properties of the drug "Metamax" in ampoules? Instructions for use indicate that due to its characteristics, this tool has a wide pharmacological effect. It activates humoral and tissue immunity, reduces the severity of signs of physical and mental stress, has cardioprotective properties, increases the ability to work and the intensity of metabolic processes.
If the patient has developed acute ischemic tissue damage, the Metamax medicine reduces the size of the necrotic zone and shortens the rehabilitation period. In chronic and acute ischemic cerebral circulatory disorders, the medication contributes to the redistribution of blood flow in ischemic zones.
In people who have heart failure of a chronic nature, exercise tolerance increases, and myocardial contractility also increases.
As for patients with chronic alcoholism, with this diagnosis, the medication in question can eliminate disorders of the nervous and somatic systems, and with dystrophic and vascular diseases of the ocular fundus, improve local blood circulation.
After intravenous administration of the solution, its highest concentration in the blood is observed for ¼ hour. The half-life is 2-4 hours and depends on the dosage. With prolonged use of the medication, its half-life may increase.
If the patient was prescribed an oral form of the drug, then the drug is very rapidly absorbed from the digestive system. After 1-2 hours, the maximum concentration of the drug is observed in the blood. Moreover, its bioavailability is 78%. The half-life of this form is 3-6 hours.
The medication is excreted from the human body mainly through the kidneys.
Indications for use
The prescription of drugs "Metamax" (ampoules and capsules) is carried out only by your doctor. As a rule, such a tool is used to treat such pathologies as:
- fundus vessels, retinal dystrophy ;
- chronic bronchitis, chronic obstructive pulmonary disease;
- ischemic circulatory disorders in the brain;
- allergic and infectious bronchial asthma;
- chronic alcoholism (for relief of withdrawal symptoms);
- reduced physical performance, including those involved in sports;
- encephalopathy;
- cerebrovascular insufficiency.
It should also be noted that the Metamax drug, the price of which will be indicated below, is very often used to reduce the duration of the rehabilitation period after surgical interventions.
Contraindications
What contraindications for use does Medication Metamax have? Ampoules and capsules can not be used with:
- breastfeeding and pregnancy;
- increased intracranial pressure, impaired outflow in veins, intracranial tumors, as well as organic lesions of the central nervous system;
- hypersensitivity to drug substances;
- children's age.
Method of use of the drug in ampoules
The dosage of the injection should be selected only by the attending physician (depending on the type of disease). As a rule, injections are given in the morning.
In case of cardiovascular diseases, patients are administered 5-10 ml of 10% daily for 4-6 weeks.
In case of circulatory disorders in the brain (in the acute phase), the drug is prescribed once a day in a volume of 5 ml.
With dystrophic abnormalities and vascular pathology of the retina, the drug is administered parabulbarly and subconjunctively every day in an amount of 0.5 ml for 10 days.
In chronic alcoholism, the drug is administered intravenously or intramuscularly twice a day, 2 ampoules for 8-10 days.
How to take capsules?
The method of use and dosage of Metamax capsules should also be determined by specialists. This form of medication is taken early in the morning, as the patient may develop a stimulating effect. With mental and physical stress, 250 mg of the drug is prescribed four times a day. In case of vascular diseases of the eyes and degenerative disorders of the retina, the injection form of the drug is first used (the first 10 days), and then they switch to oral capsule administration (0.5-1 g once a day). The total duration of therapy is 5-6 weeks.
For chronic circulatory disorders of the brain, take 500 mg of the drug per day. The duration of treatment is 5-6 weeks.
In case of heart disease, 0.5-1 g of the drug is prescribed once a day. The duration of treatment is 5-6 weeks.
Adverse reactions
The description of Metamax medicines (capsules and injections) contains information that they can cause the following side effects:
- Respiratory system: shortness of breath and dry cough.
- Central nervous system: agitation, headache, tremor, paresthesia, dizziness, psychomotor disturbances.
- Alimentary tract: dryness or hypersalivation in the oral cavity, diarrhea, dyspeptic symptoms, nausea, metallic taste in the mouth, abdominal pain, vomiting.
- Hematopoietic system: eosinophilia.
- Heart and blood vessels: changes in blood pressure, tachycardia, arrhythmia.
- General reactions at the injection site: hyperemia and pain.
- Allergy: anaphylactic shock, rash, angioedema, urticaria, redness of the skin and itching.
- Other: hyperthermia, increased sweating, chest pain, weakness, chills.
Overdose
To date, there have been no known cases of overdose with the mentioned agent. However, experts argue that when using high doses of the drug, the patient may experience symptoms that are very similar to side effects.
To treat such conditions, gastric lavage is performed, as well as a cleansing enema or a saline laxative.
Drug interaction
The combined use of the drug with cardiac glycosides, antihypertensives and antianginal drugs enhances the effect of the latter.
The Metamax medication can be combined with diuretic and antiarrhythmic drugs, as well as with anticoagulants and antiplatelet agents.
You should be extremely careful while using the drug in question with peripheral vasodilators, beta-blockers, Nifedipine and Nitroglycerin. This is due to the fact that against the background of such a combination, the patient may develop moderate tachycardia or arterial hypotension.
Drug analogs, reviews and prices in pharmacies
What can replace a medicine like Metamax? The following medicines are analogues of this remedy: Vazonat, Trimedronat, Vazopro, Celebis, Metonat, Milkardil and Mildronat.
It is impossible not to mention that all of the listed medicines have their own characteristics, adverse reactions and contraindications. In this regard, before using them, you must definitely visit a doctor.
How much is the drug in question? Prices in pharmacies for this tool may be different and depend on the markup, as well as on the form issued. On average, for medicinal capsules you will have to pay about 380 Russian rubles (for 40 pieces). As for the ampoules, they are a bit more expensive. Their cost is about 500 rubles (10 ampoules). Doctors explain this difference in price by the effectiveness of the funds. Indeed, patient reviews say that Metamax injection solution does better than the oral form of the medicine. This is due to the fact that after intravenous administration, the absorption of the drug occurs much faster and in a larger volume.