The drug "Normase" (syrup) has a hypoammonia and osmotic laxative effect. The composition of the drug includes lactulose (active ingredient) - a synthetic oligosaccharide - containing residues of fructose and galactose.
In the human body, enzymes capable of cleaving the active component of the drug are lacking. The structure of lactulose also does not change under the influence of an alkaline environment in the duodenum and an acidic environment in the stomach. Thus, the component reaches the large intestine unchanged. In the thick section, specific microflora promotes the hydrolysis of lactulose and the formation of organic acids. The main decomposition product of the component is lactic acid, however, acetic and formic acid are also isolated from the metabolites .
Lactulose promotes an increase in osmotic pressure in the lumen of the colon. Due to the increase in the volume of fluid (as a result of its transition from the blood), the volume of feces also increases. As a result, intestinal motility is stimulated.
Lactulose promotes the formation of an acidic environment, which, in turn, is favorable for the development of bifidobacteria and lactobacilli. As a result, the active component of the Normase drug is involved in the restoration and maintenance of the normal intestinal flora, ensures the absorption of necessary substances, and normalizes protein metabolism.
After oral administration of the drug, the therapeutic effect is observed after twenty-four to forty-eight hours.
The medicine "Normase", the instruction recommends for constipation, including chronic, hepatic encephalopathy (including for the prevention and treatment of precoma and coma). The drug is indicated for disorders of the microflora of the large intestine, including against the background of the development of pathogenic microorganisms. The tool "Normase", the instruction recommends prescribing for dysbacterioses associated with the use of antibiotic drugs, as well as for errors in the diet. The drug is indicated after and before surgery for hemorrhoids to regulate the stool. The drug is also prescribed for hyperamnemia, for putrefactive dyspepsia syndrome in young patients, including food poisoning.
As part of a comprehensive treatment, the drug "Normase", the instruction recommends using vaginal candidiasis and dysbiosis, as well as osteoporosis.
The medicine is allowed for use during pregnancy. Breastfeeding is not a contraindication. After the use of the drug "Normase" during pregnancy, the reviews are generally positive. Patients indicate high efficacy and good tolerance.
The medicine should be taken after meals, by mouth.
To eliminate constipation in the first three days for adults, the drug "Normase" instruction recommends taking fifteen to forty milliliters per day. After that, they switch to maintenance therapy. The dose is from ten to twenty-five milliliters per day. For patients over six years of age, 15 ml are recommended for the first three days, then a maintenance dosage of 10 ml per day. For children from one to six years old, the amount of the drug taken (in the first three days) is five or ten milliliters, for children under one year - five milliliters per day.
Duration of use - from four weeks to three to four months.
As side effects, allergic reactions, diarrhea, flatulence, nausea can occur. Prolonged use of "Normase" may provoke an upset in the water-salt balance.
The drug is contraindicated in case of intestinal obstruction and bleeding, galactosemia, hypersensitivity to galactose, fructose or drug components, with suspected appendicitis.
With extreme caution, the drug is prescribed for diabetes.
Despite the fact that the medicine is allowed for use during lactation and pregnancy, you should consult a doctor before use.