The drug “Clarithromycin” and alcohol, when combined, significantly increase hepatotoxicity. In addition, accumulating in the lung tissue, this drug can become a factor in the development of focal inflammation.
Pharmacological properties
So, let's figure out whether it is possible to take Clarithromycin with alcohol.
Under the influence of a medication on the body, the production of protein in a pathogenic cell is suppressed, as a result of which its reproduction stops. The drug is active against gram-positive microflora: streptococci, staphylococci, listeria, corynebacteria.
A broad-exposure antibiotic is also active against gram-negative pathogens and helps trigger a natural immune response. Its main distinguishing feature is its high toxicity against parasitic protists of toxoplasmosis pathogens. Due to the semi-synthetic composition, this medical device blocks their vital activity and removes strains from the foci of the pathological process.
Many people are interested, after "Clarithromycin" through how much you can drink alcohol. About it below.
Indications
The active element accumulates in the lung tissue, skin cells and muscle fibers. A similar ability is used in the treatment of the following pathologies:
- upper respiratory tract;
- mycobacterial infections;
- infectious ENT diseases;
- bacterial damage to the skin (also in the treatment of AIDS).
Recently, the effectiveness of a pharmacological drug for the treatment of gastric ulcers caused by Helicobacter pylori has been proven.
The combination of clarithromycin with alcohol
The instruction for this medical device does not provide specific instructions on its interaction with alcohol. However, many doctors recommend that you refrain from drinking alcohol during such therapy. Ethyl alcohol can enhance the development of side effects of macrolides. And in relation to parasites, it significantly increases their resistance to the drug.
That is, there is a negative interaction of Clarithromycin with alcohol.
Negative reactions
If you drink alcohol during the treatment period, the following negative reactions may develop:
- Nervous system - nightmares, sleep disturbances, feelings of anxiety. Despite the fact that this medication is well combined with sedatives, their use in certain cases can provoke the occurrence of hallucinations, persistent psychosis.
- Digestive system - nausea, enterocolitis, stomatitis, persistent diarrhea, which is difficult to eliminate even with the help of special tools. Patients with a history of alcoholism may develop nonspecific jaundice.
- Circulatory system - as a result of high toxicity to staphylococci in combination with high doses of ethyl alcohol, taking a pharmacological agent can cause thrombocytopenia.
- Sense organs - hearing impairment (in some cases persistent), noise in the head and ears, change in taste, distortion of smell.
- Skin - Steven-Johnson syndrome, urticaria, itching, eczema. Both alcoholic beverages and external use of alcohol lead to such reactions. The above complications are possible only if you drink strong alcohol. Alcohol in therapeutic doses will not disrupt the metabolism.
- Eczema - with the systematic use of alcohol before the course of therapy, cell membranes become more permeable to the vast majority of proteins. Thanks to this, pathogenic bacteria gain access to the deep zones of healthy cells. Mastering them, they can provoke any completely unpredictable reaction to the use of the drug “Clarithromycin” with alcohol, such as eczema.
Safe amount of alcohol when treated with medication
The half-life of this medication is approximately 5-6 hours. However, due to the fact that it is able to accumulate in a therapeutic dose in tissues, completely traces of the active substance will disappear from the body only after 48 hours. At this time, you must refrain from drinking.
Clarithromycin is allowed to start a therapeutic course 2-3 days after the last use. So much time on average is necessary for alcohol to be processed. However, based on a blood test, a specialist can prohibit the use of alcohol for another month after treatment.
Nevertheless, the compatibility of the drug “Clarithromycin” and light alcoholic beverages can be called conditional. This means that for a healthy adult, a small amount of a low-alcohol drink is not contraindicated.
Therapeutic standards
The so-called therapeutic standards are:
- beer - in a volume of 300 ml (strength not more than 4%);
- non-alcoholic beer - up to 500 ml;
- white or red wine - 200 ml;
- drinks with a high content of ethyl alcohol - 100 ml.
Alcohol after Clarithromycin is best taken at least two hours later.
A more active reaction can provoke an external dosage form of this medication. Ointment accelerates the metabolism of the active element in the skin and its excretion into the bloodstream. Once it enters the liver and combines with ethanol derivatives, it can cause hypothyroidism.
What else do you need to know?
Since this drug can be prescribed to children after 12 years, pediatricians warn about the likelihood of complications when using home methods of reflexology. The use of alcohol compresses, rubbing and lotions becomes a factor in the occurrence of various disorders. The combination of "Clarithromycin" with alcohol can cause the following pathological conditions:
- nonspecific otitis media;
- severe skin lesions;
- impaired consciousness;
- drug intoxication.
Most of all, the drug accumulates in the cells of the epidermis. After combining with ethanol, blood protein metabolism is blocked, which makes it possible to develop puffiness, hypotension and anaphylaxis.
With extreme caution, this antibacterial medication should be taken simultaneously with other medicines for the treatment of otolaryngological disorders. As a rule, despite a good therapeutic effect, they have increased toxicity to the tissues of the organs of the hearing aid. A high concentration of Clarithromycin can provoke a hyperreaction and cause complete hearing loss.
Since the drug gives cross-resistance with some other antibiotics, interaction with alcohol leads to the stability of a similar effect, which can lead to the inability to treat macrolides. Today, these are the only medications that can defeat many pathogenic microorganisms.
Consequences of concurrent administration
Antibiotics, such as Clarithromycin, increase the load on the internal organs, mainly on the liver, and can cause serious side effects. Alcohol is also unsafe for the body and causes severe intoxication.
As a result of simultaneous administration, the following negative consequences are possible:
- increased hangover;
- increased load on the kidneys and liver;
- severe dizziness;
- fainting
- heart pain, heart attack;
- mental disorders.
In addition, antibiotics when interacting with ethanol cause the Esperal effect - a sharp decrease in alcohol resistance, severe intoxication with the likelihood of coma and death.
We examined the compatibility of Clarithromycin with alcohol.