The composition of the drug "Oktolipen 600" as the main component includes thioctic (or alpha-lipoic) acid. The active ingredient is contained in an amount of 600 milligrams in one capsule (or tablet, depending on the form of release).
Composition, storage and sale conditions
It is available in one of three possible forms: a tablet, capsule or ampoule with the concentrate necessary for the preparation of solutions for droppers.
As auxiliary components are used: in tablets - calcium hydroorthophosphate (white or colorless crystals), magnesium stearate (finely divided white-gray powder) and titanium oxide - white dye. In capsules, slightly different substances are used that provide a partially liquid structure - gelatin, colloidal suspension of silicon oxide, as well as two yellow dyes: quinoline yellow and "sun sunset" (E 104 and 110, respectively). Ampoules with concentrate are supplied complete with a solvent from a mixture of distilled water and EDTA soluble salt.
Drug action
It has a list of positive effects on the body. Among them:
- Neuroprotective - protection of nerve cells, including brain cells, from the negative effects of certain diseases and poisonings. Allows to slightly reduce the negative effects of neurotoxin poisoning. Increased axonal conductivity and trophic neurons.
- Hypoglycemic - a decrease in total blood sugar. It is able to help patients with diabetes with complex therapy in case of polyneuropathy. Use with caution to people immediately after taking insulin or to people with increased pancreatic activity.
- Hypocholesterolemia - causes a decrease in blood cholesterol, so this drug is taken with liver failure, fatty degeneration and other liver cirrhosis.
- Hepatoprotective - the drug weakens or eliminates pathogenic effects on the liver, aimed at changing and cell death. It is taken as part of complex therapy for hepatitis, slowing down the course of the disease and easing seizures.
- Hypolipidemic - measures aimed at reducing the overall level of lipids in the blood; reduces the risk of atherosclerotic plaques on the walls of the vessel.
It is believed that thioctic acid is a powerful internal antioxidant that activates only after passing through the digestive tract.
Alpha-lipoic acid additionally lowers the concentration of sugar in the blood and partially overcomes the effect of insulin resistance. By increasing the degree of glucose uptake by the body, it contributes to an increase in glycogen deposition in the liver tissues. By its properties, thioctic acid is similar to B vitamins, takes part in sugar and fat metabolism in the body, due to the conversion of cholesterol to a biologically non-hazardous form (cholesterol metabolism) improves the functioning of the hepatic glands.
The active substance from tablets and capsules is very quickly absorbed into the blood, but it should be remembered that the simultaneous administration of medicine and food slows down the absorption of the components of the medicine. The highest concentration in the body is observed thirty to thirty-five minutes after ingestion.
Regardless of the type of administration (oral or infusion), Oktolipen 600 is processed in the liver and excreted by the kidneys almost completely - no more than ten percent remains in the body after two half-lives - seventy minutes.
Indications for use
The medicine "Okolipen 600" in the form of capsules is used for polyneuropathy of any origin (diabetic or alcoholic).
Oktolipen 600 itself, whose ampoules appear on sale much more often than capsules, has a wider range of applications. The drug is prescribed for the following diseases:
- Dystrophy of the liver caused by fatty degeneration due to cancer or alcoholism.
- Hepatitis in chronic form.
- Severe poisoning.
- An excess of lipids in the blood due to dysfunction of the organs of the gastrointestinal tract and liver.
- Cirrhic metamorphoses in the liver.
- Hepatitis A at any stage.
- Mushroom poisoning, including pale grebe.
Contraindications
The drug "Oktolipen 600", analogues and other similar substances from other groups of drugs has a small number of contraindications. The abstract offers a total of four non-specialized contraindications:
- The presence of hypersensitivity to the active substance in the drug, less often to secondary components.
- Period of pregnancy.
- Milk feeding a baby.
- Children's age up to six years.
Side effects
The drug "Oktolipen 600" has an impressive range of side effects, but most of them are practically not considered, since such reactions occur less often than one in three hundred thousand people. The most common of them include:
- Allergic reactions (from minor urticaria and / or itching at the site of contact of the drug with the mucosa to edema of the respiratory tract and anaphylactic shock).
- Side effects of the gastrointestinal tract are rarely observed, including vomiting, burning in the stomach, and nausea.
- The most common phenomenon is the symptoms of low blood sugar (hypoglycemia): fatigue, dizziness, drowsiness - however, they are all quite well removed by taking a teaspoon of sugar.
Admission Rules
“How to take Oktolipen 600?” - many buyers ask. Patients who are prescribed for the drug "Oktolipen 600" should adhere to the following intake: one tablet is taken half an hour before meals on an empty stomach (woke up - drank a pill - waited - ate).
A single daily dose of 600 milligrams is prescribed: one or two tablets or capsules. At the same time, the duration of administration and dosage of the drug remain the responsibility of the doctor, and they can be changed depending on the disease.
In order to increase the overall effectiveness for severely severe patients, the drug is prescribed intravenously over a period of approximately three weeks. Then, after this period, the patient is transferred to a standard course of treatment: one tablet per day.
For administration through a dropper, the preparation is prepared according to the following technology: the contents of one or two Octolipen 600 ampoules are dissolved in a certain amount (from 50 to 250 milliliters) of physiological saline — the ratio of sodium chloride to the total mass of the mixture is 0.9 percent. The diluted concentrate is consumed, usually within two hours, the introduction to the body is carried out intravenously through a dropper. Such a prescription of the solution for infusion allows you to achieve entry into the patient’s body from three hundred to six hundred milligrams of the drug “Okolipen 600”.
Instructions for use, price - all this calls for the careful use of the drug. The drug has an increased vulnerability to the action of sunlight, and therefore the ampoules of the concentrate should be opened immediately before use. Moreover, even a divorced medicine in the light decomposes, forming toxic substances. Store the product in a dark, dry place; the finished solution loses its properties and safety standards after 6 hours.
Overdose
When taken in excess of the dose of Oktolipen 600, the standard symptoms are observed: severe headaches, loss of orientation, and also increased side effects such as nausea, heartburn and vomiting. A therapy is prescribed, which consists in eliminating the negative reactions of the body. Can be taken: analgin, activated carbon; gastric lavage or taking a suspension of magnesium oxide is acceptable.
Interaction with other drugs
Due to the hypoglycemic effect, the effectiveness of insulin and other drugs for diabetes is seriously increasing, so you should carefully monitor the amount of glucose in the blood. Depending on the effect, the dosage and number of doses of antidiabetic drugs may vary, however, it is unacceptable to use only "Oktolipen 600" - the drug will work only in the presence of other drugs.
A certain period of time is required between taking dairy products and Oktolipen 600. The reviews also suggest that the simultaneous administration of calcium and iron-containing drugs reduces the effectiveness of thioctic acid - at least a ten-hour gap between applications is necessary. However, Oktolipen activates and enhances the anti-inflammatory and antipyretic effects of glucocorticosteroids (cardiac drugs).
When taken with alcohol, the effectiveness of "Oktolipen" seriously decreases, which is why you should refrain from drinking alcohol during the course of taking the drug.
Analogues of the drug
The best medicine from this group is Oktolipen 600. Instructions for use, price - all this suggests that this tool is a good and effective equivalent to many drugs, such as Berlition and Neuroleepone - the most common representatives of the same class of drugs.
Customer reviews
Oktolipen 600 has many positive reviews; as a rule, many patients highly value this drug - it is much cheaper than Berlition, but more effective than Neuro Lipone, which is why it is most preferred when buying and prescribing.
An ampouled drug is sold at an average price of 380 rubles, and tablets and capsules dispensed with a doctor’s prescription have a cost of 290-300 rubles.
And remember - take care of your health. Do not self-medicate, Oktolipen 600 tablets should be taken purely after consulting a doctor. Self-administration of the drug without a doctor’s prescription can lead to bad consequences for your health, even death.