The medicine “Celebrex” describes the instructions for use as a non-steroidal anti-inflammatory drug with pronounced antipyretic and analgesic properties. The action of this drug is based on the suppression of prostaglandin synthesis due to inhibition of COX-2. At the same time, Celebrex tablets, the use of which confirms this, to a much lesser extent than other non-steroidal anti-inflammatory drugs, contribute to the development of so-called gastroduodenal ulcers. As for the pharmacokinetics of this drug, its highest concentrations are noted one hundred and twenty minutes after use, and the half-life is about eight to twelve hours.
The Celebrex tablets are recommended for use as part of the complex therapy of diseases such as rheumatoid arthritis, spondylitis, algodismenorrhea and deforming osteoarthritis. In addition, this remedy is also prescribed for the relief of pain caused by surgical interventions or injuries. According to the annotation, it can also be used to treat patients with a diagnosis of familial adenomatous polyposis.
The main contraindications to the appointment of such an anti-inflammatory drug as the Celebrex medicine are individual intolerance to celecoxib, an allergic reaction to sulfonamides, as well as the condition after coronary artery bypass grafting. In addition, you should not take this drug for people suffering from bronchial asthma, inflammatory bowel disease or heart failure.
In case of hypersensitivity to acetylsalicylic acid, you should also not start taking Celebrex tablets . Doctors' reviews also indicate the undesirability of their use by people with severe renal or hepatic insufficiency. The list of contraindications includes up to eighteen years of age, the period of bearing a child, the lactation period, coronary disease, gastrointestinal bleeding, peripheral arterial disease and peptic ulcer. With extreme caution, take the drug "Celebrex", the instructions for use advise in case of disorders in the cardiovascular system, hyperlipidemia, dyslipidemia and diabetes. People with cerebrovascular diseases, somatic diseases, peptic ulcer disease and a predisposition to edema and fluid retention should also refrain from using this anti-inflammatory drug.
The list of possible adverse reactions associated with taking Celebrex tablets includes tinnitus, thrombocytopenia, heart rhythm disturbance, alopecia, and arterial hypertension. In addition, some patients complain of increased anxiety, coughing, upset stools, nausea, dysphagia, diarrhea, and angioedema.