In this article, we will consider instructions and reviews for the Niperten drug.
It is a modern medicine that helps relieve headaches associated with unstable pressure. “Niperten” is referred to as beta-blockers. This medicine enriches the myocardium with oxygen, regulating the number of contractions of the heart and controlling the blood plasma renin. The effectiveness of this drug is possible due to antianginal effects, and, in addition, hypotensive and antiarrhythmic properties.
This is indicated in the instructions for use with Niperten. At what pressure is it prescribed?
This drug is prescribed for the treatment of hypertension and angina attacks. Thus, this tool is perfect if a person suffers from high blood pressure.
The composition of the funds
The main component of this medication is bisoprolol fumarate. The chemical composition of one tablet of the drug may contain 2.5, 5 or 10 milligrams of active active compound. Auxiliary components are povidone along with magnesium stearate, carboxymethyl starch and colloidal silicon dioxide. The film membrane contains titanium dioxide, talc and macrogol. The instruction for Niperten tablets is very detailed.
What are beta-blockers?
These components have a beneficial effect on adrenoreceptors located in the heart, as well as in its vessels. In a healthy person, adrenoreceptors are affected by adrenaline or norepinephrine. Adrenaline comes into contact with adrenoreceptors, provoking several of the following reactions:
- The narrowing of the vessels of the heart, as a result of which the lumen becomes smaller.
- Pressure increase.
- The appearance of anti-allergic effect.
- Expansion of the lumen of the bronchi.
- The release of glucose into the blood.
Thanks to adrenergic blockers, it is possible to achieve the opposite effect. Thus, the narrowed vessels expand again, their normal operation is ensured, the pressure, in turn, normalizes. In addition, the bronchi come to a normal state. And the level of glucose in humans is also normal. The described property is inherent in all drugs from the category of adrenergic blockers.
What helps Niperten?
According to the instructions, Niperten is prescribed by the attending physician in case of frequent or constant increase in pressure, as well as in the presence of heart failure. In addition, this medicine has a very good effect on diseases that are caused by poor blood flow to the heart, which is observed with myocardial damage. The doctor, according to indications, can offer this medicine for the prevention of angina attacks.
How does this tool work?
The work of the heart is restored due to an increase in the number of AMP molecules. Under the influence of "Niperten" in the body, too much excitability of nerve cells is restored. A decrease in tachycardia occurs due to a decrease in the supply of oxygen cells to the heart. Against this background, the coronary arteries relax, and as a result, pain in the chest passes. It is arterial spasms that usually in this case cause burning sensations with dull, pressing pain under the ribs.
Pressure regulation occurs due to a decrease in total blood volume, and blood vessels, in turn, are stimulated. From the beginning of treatment with this medicine, the state of the vessels in the patient returns to normal, and the person experiences a relief of his condition.
With the regular use of this drug throughout the treatment, a steady effect of pressure stabilization is achieved. In that case, when compared with the effect of similar drugs, it is not active in terms of its effect on metabolic carbohydrate processes. This is confirmed by the instructions for use with Niperten.
It also has a slight effect on other organs whose tissues contain beta-adrenergic receptors. These organs include the pancreas, uterus, lungs and blood vessels. This drug is absorbed by almost one hundred percent, and is metabolized by the liver. As for the processes of excretion, then they are taken solely by the kidneys.
How is it absorbed after administration?
As the instruction for Niperten indicates, the active substance bisoprolol is absorbed from the digestive system by almost ninety percent. Ten percent more is absorbed through the liver, where the rest of it enters. Reception of products does not have any effect on the bioavailability of the product, therefore it is allowed to use it regardless of food. The maximum concentration in blood cells occurs three hours after taking the medication.
What else does the instruction for Niperten 2.5 and 5 mg tell us?
Active ingredient metabolism
Bisoprolol is able to metabolize along oxidative pathways without conjugation and the process of convergence of homologous chromosomes. Metabolites in plasma or urine are pharmacologically inactive.
Dosing for arterial hypertension
In accordance with the instructions for Niperten, for this disease, and, in addition, for the prevention of angina pectoris, the recommended dosage of the drug is 5 milligrams per day. In the event that there is a need, the dosage is increased to 10 milligrams. The maximum allowable rate is 20 milligrams per day. For patients with liver problems, the maximum dose is 10 milligrams per day. For elderly patients, a dosage adjustment is not required.
Chronic heart failure dosage
As the instructions for use for Niperten informs us, in order for the treatment to be effective and not to aggravate the patient’s condition in any way, the remedy requires preparatory selection of doses. The following factors must be absent for the use of this drug:
- The presence of signs of exacerbation of chronic heart failure for at least seven weeks.
- Basic treatment changes.
Among other things, it is necessary to carry out primary treatment with vasodilator drugs or inhibitors, and, in addition, diuretics. In addition, cardiac glycoside therapy does not interfere. An individual reaction is likely to occur with Niperten treatment. Each time, the dose can be increased provided a good response to previous volumes of the drug. So, the treatment regimen is as follows:
- In the first week, they take 1.25 milligrams of Niperten once a day. This is a half-tablet of Niperten 2.5. The instructions for use confirm this.
- In the second week, one tablet per day is required.
- The third week involves taking 3.75 milligrams per day. This is a whole plus one half of the Niperten 2.5 mg tablet. Instructions for use should be studied in advance.
- Starting from the fourth to the seventh, take tablets of 5 milligrams. One tablet per day.
- Seventh to eleventh take 7.5 milligrams.
- From the twelfth week until the end of the treatment course, one tablet of 10 milligrams is taken.
After the first use of the minimum dose of the drug, the patient is observed for four hours, measuring his pressure with a pulse. In addition, an electrocardiogram is carried out, monitoring the general condition. If minor temporary worsening occurs, the doctor adjusts the dose. Discontinuation of treatment with this drug is carried out in extreme cases.
Instructions for use with Niperten tablets do not end there.
Adverse reactions in patients receiving
The nervous system can respond to increased fatigue, weakness, dizziness, headache, sleep disturbance, depression, anxiety, and confusion. Short-term memory loss is not ruled out along with hallucinations, asthenia, myasthenia gravis, paresthesia in the extremities, tremors, and seizures.
Probably a violation of the organs of vision. At the same time, a decrease in tear fluid secretions is observed along with dryness and soreness of the eyes. Conjunctivitis is not excluded. So it is said in the instruction to Niperten.
The work of the heart and blood vessels can be accompanied by sinus bradycardia, palpitations and impaired myocardial conduction. Probably the development of complete transverse blockade along with cardiac arrest. Arrhythmias, weakening of myocardial contractility, aggravation of chronic heart failure, which will manifest itself in the form of swelling of the ankles and shortness of breath, are possible. Pressure may decrease. The development of orthostatic hypotension and the occurrence of angiospasm, in which the violation of peripheral circulation will intensify and cooling of the extremities, will not be ruled out. Chest pains are also possible, and in the event of a sharp withdrawal, angina attacks may intensify and pressure will increase even more.
On the part of the digestive system, people can notice the appearance of dry mucous membranes of the mouth, nausea, vomiting, abdominal pain, constipation or diarrhea. There may be impaired liver function, which will manifest itself in the form of dark urine, yellowness of the sclera or skin, and, in addition, in the form of cholestasis. Probably an increase in bilirubin levels and a change in taste.
The respiratory system may be accompanied by nasal congestion and shortness of breath. This is usually observed in the case of the appointment of high doses of the drug. Among predisposed patients, the development of bronchospasm is possible.
The endocrine system can respond with hyperglycemia, which is especially common among patients with non-insulin-dependent diabetes mellitus. Hypoglycemia can occur in patients who receive insulin. The occurrence of a hypothyroid state is not ruled out. As allergic reactions, itchy skin with a rash and hives is possible. This is confirmed by the instructions for use and reviews of "Niperten."
Dermatological reactions, as a rule, are expressed in the form of increased sweating, skin hyperemia, exanthema and psoriasis-like skin rashes. In addition, an exacerbation of the symptoms of psoriasis and alopecia is likely. From the skeletal and muscular systems, spasms of the calf muscles, back pain and arthralgia are possible. On the part of the reproductive system, patients sometimes experience a weakening of libido along with a decrease in potency. The hematopoietic system may respond with thrombocytopenia, agranulocytosis or leukopenia. The work of metabolism may be accompanied by an increase in the content of triglycerides.
What you need to know in the treatment of Niperten 2.5 and 5 mg?
The instruction for Niperten reports that there are special instructions that are associated with the use of this drug. For example, doctors strongly do not recommend abruptly cutting off treatment with this medicine, and, in addition, changing the dose of the drug at their discretion. Such an initiative can dramatically worsen heart function, especially for patients with coronary artery disease. If there is an urgent need for withdrawal, the doctor will draw up a scheme for the gradual reduction in the use of Niperten. At the beginning of admission and completion, patients must be checked regularly.
Drug cost
Tablets are available at their cost:
- A dosage of 10 milligrams costs around two hundred rubles for thirty tablets.
- A dosage of 5 milligrams will cost people about one hundred and fifty rubles.
- And the price of a dosage of 2.5 milligrams is in the region of one hundred rubles for thirty tablets.
Such information is not in the instructions for use.
Analogs of Niperten
Before describing analogues, it should be noted that their prices are average. The exact cost may depend on the pharmacy network, the region and a number of other reasons. So, Bisoprolol in tablets is one of its analogues. This analogue is not much different, since the active substance in this case is the same. This drug is produced in our country, and the cost is from fifty rubles for thirty tablets.
Aritel tablets are another analogue of Niperten Russian-made. The active ingredient is the same as that of Niperten. Application along with contraindications are also similar. And the cost starts from one hundred rubles for thirty tablets. Bidop tablets will cost customers a little more than Niperten. The cost starts from one hundred and thirty rubles. The composition also has some differences, and the contraindication is identical.
“Biol” in tablets is another analogue, identical with “Niperten” in composition and cost. The price for it starts at one hundred and twenty rubles for thirty pieces. An inexpensive analogue of Niperten is Biprol in tablets, whose price starts from sixty rubles for thirty tablets. There is also the drug "Coronal", this analogue is not too expensive, its cost starts from one hundred and twenty rubles.
Difference between Niperten and Niperten Combi
The Niperten Combi preparation contains a combination of two active elements in the form of amlodipine and bisoprolol. This drug also belongs to drugs from the category of beta-blockers. The substance amlodipine blocks the calcium tubules, creating an effect on the transmembrane current of calcium ions. This medicine saturates the myocardium with oxygen well, reducing the tone of blood vessels and regulating the number of heart contractions. Like Niperten, this drug controls blood plasma renin.
The effectiveness of the drug becomes possible due to antianginal action, as well as due to hypotensive and antiarrhythmic manifestations. This drug is prescribed for the treatment of hypertension. It is also used to prevent angina pectoris. Thus, the main difference between this analogue and Niperten is an additional active substance and a more effective result.
Reviews on Niperten
In reviews of this drug, people write that the tool is very effective, in addition, it is not expensive. Many are embarrassed by the need for long-term use, but in the process of treatment, according to people, there really is a noticeable improvement in well-being.
People do not like the fact that Niperten causes a lot of adverse reactions. For example, it is reported that against the background of its intake, some have a headache. Doctors usually warn that this happens. And, as people write, over time the pain goes away, and the drug helps to cope with angina pectoris and high blood pressure.
Some reviews say that for older people, these pills are not always suitable. For example, an acute skin reaction is reported. In such cases, doctors Niperten cancel, prescribing a safer analogue.
Thus, this drug is suitable for someone, but not for someone. But those people to whom he approached report that this drug copes with high blood pressure perfectly, and at the same time, patients do not notice any adverse reactions.
We reviewed the instructions and reviews for Niperten.