To stimulate the immune system, drugs based on interferon, which has an immunomodulating, antiviral and antitumor effect, have been created. Penetrating into the body, the active substance binds to cell receptors and causes targeted intracellular reactions.
Developed by Biopharma (Ukraine), the Laferobion drug for children and adults improves immunity, copes with viral and bacterial infections, and fights against malignant neoplasms.
All dosage forms
The drug is available in the form of:
- rectal suppositories of 3000 thousand, 1000 thousand, 500 thousand or 150 thousand IU, packed in blisters for 10, 5 or 3 pieces;
- lyophilized powder of 100 thousand, 1000 thousand, 5000 thousand or 3000 thousand IU in plastic bottles, 10 bottles are contained in one package;
- lyophilized powder of 6000 thousand, 9000 thousand or 18 000 thousand IU in plastic bottles, one package contains 1 bottle;
- nasal powder of 500 thousand or 100 thousand IU in a bottle for which a dropper cap is provided.
For Laferobion in ampoules, the instruction contains information on the presence in packs of ampoules with 1 or 5 ml of purified water for dilution.
Description of the drug
Powder-lyophilisate in the form of a white hygroscopic porous mass, is used to prepare a solution for injection.
Powder-lyophilisate in the form of a uniform light mass, is used to prepare a nasal solution.
Both ampoule forms of the Laferobion preparation possess hygroscopic properties. The instruction describes the liquid obtained after dilution as a clear, slightly colored solution. The nasal form is used for inhalation, injection and instillation. The injection solution is administered intramuscularly, subcutaneously and intravenously dropwise.
Powder composition
The active ingredient of the Laferobion medication in ampoules is called recombinant human interferon. It is identical to alpha-2b-interferon and is synthesized by white blood cells that are affected by the interferonogen virus. The medication exhibits an immunomodulatory and antiviral effect, which does not show toxicity when ingested through the respiratory organs.
The digital value in the name of the medicine indicates the amount of active substance in the international unit of measurement (ME). For example, the preparation “Laferobion 100000” in ampoules for the preparation of an injection solution contains 10 5 IU of recombinant human alpha-2b-interferon . Auxiliary components are sodium chloride, dextran, potassium dihydrogen phosphate, disodium phosphate dodecahydrate.
The composition of rectal suppositories "Laferobion 150,000" contains 150 thousand IU of recombinant human alpha-2b-interferon. Inactive components include ascorbic acid, tocopherol acetate, and solid fat.
Nasal powder contains 100 thousand or 500 thousand IU of recombinant human alpha -2b-interferon. The inclusion of sodium chloride, dextran 70, potassium dihydrogen phosphate, disodium phosphate dodecahydrate allows you to create a stable mixture.
How does the medication
The action of the drug “Laferobion” in ampoules is determined by the properties of natural leukocyte interferon. It is he who exhibits antiviral, antitumor and immunomodulating activity and is non-toxic.
The role of interferon in the treatment of many diseases is associated with the launch of a number of biochemical reactions leading to protein synthesis, inhibition of tissue growth, immunomodulating activity of phagocytic, macrophagocytic and lymphocytic cells, and suppression of the reproduction of viral and other altered cells.
Comprehensive treatment for infections
For Laferobion medication, the instruction includes indications for use, divided into three main groups. The first of these includes diseases caused by viral or bacterial infections.
The drug allows you to cope with the herpes virus, including causative agents of genital herpes, herpes eyesight, shingles, herpetic rashes on the skin, papillomavirus infection in genital warts, vulgar warts, keratoacanthomas.
It is used in chronic hepatitis B, D, C in adulthood and childhood, in acute hepatitis C and B, tick-borne encephalitis of the meningeal form, for the treatment of cirrhosis of the liver in combination with hemosorption and plasmapheresis.
Laferobion medication is used to treat children who, along with chronic hepatitis D, C, B, have signs of lymphogranulomatosis, leukemia, solid tumors, with acute hepatitis C, with perinatal hepatitis C or B, with serous meningitis caused by enterovirus.
The drug is effective in adulthood with influenza and acute respiratory viral infections that have complications in the form of superinfection.
The medicine “Laferobion” can be given to newborns and premature babies with pneumonia, acute respiratory viral infections, sepsis, meningitis, intrauterine infection, which includes manifestations of herpes, visceral candidiasis, chlamydia, CMV and enterovirus infection, ureaplasmosis, mycoplasma.
The drug is also suitable for pregnant women with urogenital infections associated with chlamydia, papillomavirus infection, ureaplasmosis, CMV infection, bacterial vaginosis, trichomoniasis, mycoplasmosis, genital herpes, vaginal candidiasis, gardnerellosis, chronic pulmonary disease, hepatonephritis, pyrex disease and B.
Comprehensive treatment for oncology
The second group of indications includes the treatment of malignant neoplasms, characterized by melanoma of the skin and eyes, tumors of various organs (in the ovaries, kidneys, bladder, mammary glands), myeloma, Kaposi’s sarcoma and other malignant tumors.
Combined therapy of other diseases
Laferobion drug (ampoules) for children is used for such diseases as: insulin-dependent diabetes mellitus, asthma, glomerulonephritis, pyelonephritis, intestinal dysbiosis, chronic gastritis, duodenitis, chronic inflammation in the large intestine, mumps of varying severity, localized diphtheria.
Perhaps the use in complex therapy for juvenile rheumatoid arthritis, multiple sclerosis, prostatitis of various origins, purulent complications after surgery.
Use of nasal solution
Before using the drug, you need to prepare a solution of Laferobion powder. How to breed lyophilisate - prompt instructions.
The effectiveness of inerferon therapy will be high at the initial stage of the disease with the appearance of the first signs. Acute respiratory viral diseases, including influenza, bacterial viral infections are treated by inhalation, injection or instillation of the nasal passages with Laferobion solution.
When instilling the drug, it is recommended to use 5 drops in each nostril, which corresponds to 0.25 ml of a solution whose activity is from 50 to 100 thousand IU of interferon. This procedure is carried out with a frequency of 1-2 hours about 6 times a day for 3 days.
An ultrasonic inhaler is used for inhalation through the oral cavity or nasal passages. A solution prepared from the contents of three vials is poured into it, for which the powder of the drug is dissolved in 5 ml of boiled or sterile water. This procedure is carried out twice a day.
Treatment of infants up to 1 month is carried out with nasal turundas moistened with the diluted Laferobion drug, they are administered in turn, in each nostril for 15 minutes. When instilled into such babies, a dosage of 50 thousand IU is used, the solution is administered in 3 drops into each nostril 4-6 times a day. The duration of treatment is 3-5 days.
For preventive purposes, in order not to get an acute respiratory viral infection during an epidemic or communicating with a sick person, usually use a dosage of 50 to 100 thousand IU per 1 ml, 5 drops of the drug, which corresponds to 0.25 ml, twice a day with a difference at 6:00.
How to breed nasal powder
The entire unsafe period should be instilled or injected with a solution of the drug "Laferobion" (in ampoules). How to breed powder to obtain a solution with an activity of 50 thousand or 100 thousand IU is described in the instructions. The contents of one bottle are taken and dissolved in 1-2 ml of purified and sterile water, while the bottle should be shaken well.
Using injection
The injection solution is intended for intramuscular, subcutaneous, intradermal, intraperitoneal, intravesical use of the drug "Laferobion" (in ampoules). How to breed the lyophilisate correctly and for what diseases to use, you can learn from the instructions. Usually, 1 ml of injection water is diluted in one bottle.
The treatment regimen for acute hepatitis B: 1000 thousand IU twice a day for the first 5 days, then the same once a day for the next 5 days. In case of insufficiency of therapy, 1000 thousand IU are continued to be administered 4 times in two weeks. In the initial stages of the icteric stage, the effect of the drug is most noticeable than with later uses.
The treatment regimen for the chronic form of hepatitis B: in the active phase of 3000-6000 thousand IU three times in 7 days, the course lasts about 24 weeks. At 12 weeks, determine the titer of HbeAg, with insufficient effectiveness, the drug is canceled.
The treatment regimen for the chronic form of hepatitis C: 3000 thousand IU three times in 7 days, the duration of therapy is about 24 weeks. After 4 weeks, the content of AlAT is determined; at its high level, a dose of 6000 thousand ME is used. At 12 weeks, the effect of the drug is evaluated, and in the absence of positive dynamics, treatment is canceled.
The treatment regimen for tick-borne encephalitis: 1000-3000 thousand IU twice a day for 10 days, then 1000-3000 thousand IU with the same frequency for the next 10 days.
Cancer treatment regimen: taking maximum doses for a long time. Chronic myeloid leukemia - 9000 thousand IU per day until the manifestation of remission, then 9000 thousand IU three times in 7 days.
Lymphocytic leukemia - 3000 thousand IU per day before the onset of remission, then the same three times in 7 days.
Renal cell carcinoma - 18,000 thousand IU three times in 7 days.
Use of the drug for infusion
For infusion use the drug "Laferobion". How to breed and apply drip can be found in the instructions.
Before the infusion of the solution with interferon, an isotonic sodium chloride solution of 0.9% is dripped for 30 minutes, its injection rate is 200 ml per hour.
Prepare the Laferobion infusion solution by dissolving the desired dose in 1 ml of injection water. After the initial solution is mixed with 50 ml of 0.9% isotonic sodium chloride solution. The finished liquid preparation is administered dropwise intravenously for 30 minutes, and then an isotonic solution of 0.9% sodium chloride is continued to drip again for 10 minutes at a rate of 200 ml per hour.
Using candles to treat children
Children of premature and newborns can be treated with Laferobion rectal suppositories at a dose of 150 thousand IU. On a day put 1 candle twice with a frequency of 12 hours, the course of therapy is 5 days.
In bacterial pneumonia in infants, 1 suppository dose of 15 thousand IU is used three times a day. From 4 months, the dosage can be increased to 500 thousand IU twice a day, 1 each; from 6 months, 2 candles are administered twice a day.
Side effects
The undesirable consequences of taking the drug "Laferobion" (in ampoules), the instruction lists according to the body systems. The systems that are most susceptible to the effects of medication are: circulatory, cardiovascular, endocrine, digestive, musculoskeletal, nervous and sexual.
The general condition of the body resembles the flu, manifested by pain in the muscles and joints, pain in the eyes, headache, asthenia, chills.
When not to use
The medicine "Laferobion 100000" in ampoules the instruction does not recommend taking with:
- allergies to alpha interferon and other components;
- autoimmune hepatitis;
- decompensated liver disease;
- creatinine clearance below 50 ml per minute;
- low hemoglobin.
Cost
Many are prescribed Laferobion (ampoules). The price of one package with 10 bottles in a dosage of 100 thousand IU of nasal powder will be about 96 rubles. Treatment with injections will cost more. For one ampoule of 1000 thousand IU, you will have to pay about 320 rubles. Young mothers, of course, will be interested in another price: Laferobion for children in candles with a dose of 150 thousand IU, 5 pieces per package, costs about 530 rubles.