Today we will tell you about a drug like Spitomin. Instructions for use, price, reviews, analogues and its features - all these points are of interest to patients to whom the doctor prescribed this medicine. You will find all the necessary information later in the article.
Description of the drug, its form, packaging and composition
What is the medicine "Spitomin"? Instructions for use (the description of the drug is presented in great detail) claims that these are odorless white, round and flat tablets, with a bevel, as well as with a mark and engraving “E151”.
This product contains buspirone hydrochloride and such auxiliary components as carboxymethyl starch, lactose monohydrate, sodium magnesium stearate, microcrystalline cellulose and colloidal anhydrous silicon dioxide.
On sale, this medicine comes in blisters and cardboard packs.
Operating principle
What features does the medicine “Spitomin” have? Instructions for use (the price of tablets are presented below) claims that this is an anxiolytic drug that belongs to the non-benzodiazepine series and has an antidepressant effect.
Unlike other anxiolytics, this drug does not have antiepileptic, sedative, hypnotic and muscle relaxant properties. Its principle of action is based on the effects of buspirone on the dopaminergic and serotonergic systems.
This agent selectively blocks dopamine receptors (presynaptic) and increases the rate of excitation of neurons (dopamine) of the midbrain.
What other properties are inherent in the drug "Spitomin"? Instructions for use states that buspirone is a selective partial agonist of 5-HT1A-serotonin receptors. It does not affect benzodiazepine receptors and GABA binding, nor does it affect psychomotor functions and does not cause tolerance. In addition, this tool does not potentiate the effect of alcoholic beverages.
The therapeutic effect of the medication in question develops gradually and is observed one or two after the start of treatment.
Kinetics means
The absorption of the drug "Spitomin", the instructions for use of which are presented below, occurs in the digestive tract. Buspirone is extensively metabolized as it passes through the liver. Its bioavailability is 4%, and the highest plasma concentration is reached after an hour.
Buspirone is excreted along with milk. There is no information on the penetration of this drug through the placental barrier.
The drug is excreted with feces for five hours.
Indications
Why prescribe Spitomin tablets? Instructions for use indicate the following indications:
- autonomic dysfunction syndrome;
- generalized anxiety disorder ;
- alcohol withdrawal syndrome (in the form of adjuvant therapy);
- panic disorder ;
- depressive disorders (in the form of adjuvant therapy).
Contraindications
In what cases is it not recommended to use Spitomin tablets? Instructions for use indicate the following pathologies and conditions in which the medication is contraindicated:
- glaucoma;
- hypersensitivity to the ingredients of the drug;
- myasthenia gravis;
- severe renal failure;
- minor age;
- concomitant use of MAO inhibitors ;
- lactation period;
- period of pregnancy.
With caution, this remedy is prescribed for cirrhosis and renal failure.
Medication "Spitomin": instructions for use
Analogues of this drug will be presented below.
The drug in question must be taken at the same time of the day, before or after the meal.
The drug should not be used sporadically (on demand) for the treatment of anxiety, since its therapeutic effect develops only after repeated use.
The dosage of this medication is selected individually. As a rule, it is 15 mg. It should be divided into 2-3 doses.
The maximum single dose of the drug is 30 mg, and the maximum daily dose is 60 mg.
In the elderly, dose adjustment is not required. In case of impaired kidney or liver function, the medication should be used with extreme caution and in small doses.
Side effects
Usually, the medication "Spitomin" is well tolerated. Only in some cases, this tool causes certain violations:
- chest pain, sleep disturbances, fainting, dizziness, arterial hypotension, headache, arterial hypertension;
- nervous irritability, cerebrovascular accident, dysphoric reactions, decompensation of heart failure, increased sensitivity to noise, myocardial infarction, dysphoria, myocardiopathy, suicidal thoughts, bradycardia;
- depersonalization, cold intolerance, euphoria, claustrophobia, hyperkinesis, tinnitus, fear, itching in the eyes, apathy, redness of the eyes, hallucinations, stuttering, confusion, psychotic disorders;
- blurred vision, laryngitis, conjunctivitis, swelling of the nasal mucosa, violation of taste sensations, feeling of heaviness in the chest, disturbances of the inner ear, hyperventilation, eye pain, lack of air, photophobia, nosebleeds, increased intraocular pressure;
- galactorrhea, nausea, thyroid damage, flatulence, bedwetting, anorexia, increased appetite, dysuria, salivation, menstrual irregularities, intestinal bleeding, delayed ejaculation, and others.
Price, analogues, reviews
The cost of this tool is about 600 rubles. If required, then replace it with an analogue such as Buspirone Sandoz.
Customer reviews report that the drug in question is a good anxiolytic agent. However, it can be taken only as prescribed by a specialist, for a long time (not occasionally).