What is the Tieolept drug for? Instructions for the use of this medication will be presented in the materials of this article. In addition, from it you will learn about the forms in which the drug under consideration is produced, what composition it has, whether it has contraindications and side effects, as well as how much it costs and how it can be replaced.
Forms of release of the drug and its composition
In what form does Tieolepta medicine go on sale? Currently, this drug can be purchased in two different types, namely:
- In tablets coated with a yellowish coating. As an active substance, this form of the drug contains thioctic acid. Also, the medication includes auxiliary elements. These include potato starch, Aerosil A-300 (or colloidal silicon dioxide), microcrystalline cellulose, primellose (or croscarmellose sodium), milk sugar (or lactose), polyethylene glycol-400 (or macrogol-400), castor oil, calcium stearate, titanium dioxide, hydroxypropyl methylcellulose, quinoline yellow, polyethylene glycol-6000 (or the so-called macrogol-6000), yellow iron oxide. One cardboard package can contain 10, 60, 30 or 90 tablets.
- In solution for infusion. As an active substance, this form of the drug also contains thioctic acid. As for the additional elements, they include meglumine, povidone, macrogol and water for injection. The drug goes on sale in bottles of 50 and 25 ml.
Pharmacological properties of a medical product
What is the medicine "Tiolept"? Instructions for use states that it is a metabolic agent. Its active substance (alpha lipoic acid) is an endogenous antioxidant that binds free radicals.
Thioctic acid is formed in the human body during the oxidative decarboxylation of alpha-keto acids. The medication helps to reduce blood glucose, as well as increase the amount of glycogen in the liver. In addition, the drug easily overcomes insulin resistance.
By its biochemical effect, the drug is very close to the vitamins of group B. The drug takes an active part in the regulation of carbohydrate and lipid metabolism. It improves liver function and stimulates cholesterol metabolism. The drug is capable of exerting hypolipidemic, hepatoprotective, hypoglycemic and hypocholesterolemic effects.
Pharmacokinetics of the drug
After taking the Tielept tablets (600 or 300 mg) inside, the active substance is quickly and completely absorbed from the digestive tract. The simultaneous use of food can significantly reduce the absorption of the drug. The bioavailability of this drug is 30%. The maximum concentration in the blood is reached after 40-60 minutes.
This drug has the effect of first passing through the liver. Metabolites are formed during conjugation and oxidation of the side chain.
The drug is removed with urine (in 80-90%).
Indications for the use of a medical device
In what cases is the medication "Tieolept" prescribed? Instructions for use contain the following list of indications:
- alcoholic polyneuropathy;
- diabetic polyneuropathy.
Contraindications to the use of a medical device
When can you not use the drug "Tieolepta"? Instructions for use of this tool contain the following contraindications:
- the period of gestation;
- children's age (safety and effectiveness of the use of the medication have not been established);
- the period of breastfeeding (there is not enough experience with the use of the product);
- hypersensitivity of the patient to the components of the drug.
How to take the medicine "Tieolept 600"?
Instructions for use of this tool say that the drug in the form of tablets is usually prescribed 30 minutes before the first meal (that is, before breakfast). The medication should be taken in an amount of 600 mg once a day. Tablets should not be chewed. They should be washed down with a small amount of water. The duration of a course of drug therapy should be determined only by the attending physician.
In more severe forms of diseases such as diabetic and alcoholic polyneuropathy, this drug is administered intravenously (only by drip). The medication is prescribed in a volume of 50 ml once a day. At the very beginning of the course of therapy, the drug is administered intravenously for 2-4 weeks. After this, the transition to the oral form of the drug in a dosage of 300-600 mg per day is possible. The injection should be administered very slowly (not more than 50 mg of active substance per minute).
Drug overdose (symptoms, treatment)
What will happen if you do not adhere to the doctor’s recommendations and take a large dose of the Tieolept drug? Experts say that in this case, the following symptoms of an overdose may occur: nausea, headaches, vomiting. How to treat a patient in case of an overdose of the drug "Tieolept"? It is necessary to carry out symptomatic therapy.
Side effects after applying the medication
As a rule, the Tieolept drug, the price of which is presented slightly lower, is tolerated relatively well by patients. However, in some cases, the following side effects still occur:
- Alimentary tract: dyspepsia, heartburn, vomiting and nausea.
- Allergy: various skin manifestations (e.g., urticaria).
- Metabolism: hypoglycemia (due to improved glucose uptake).
Interaction with other drugs
Is it possible to use injection solution at the same time or take Tielept tablets with other medications? The answer to this question should be obtained from specialists. If you do not have such an opportunity, we recommend that you carefully read the attached instructions. According to her, the drug, or rather thioctic acid, reacts well with ionic metal complexes. In this regard, the simultaneous administration of a medication can significantly reduce the effectiveness of cisplatin.
Having taken the Tielept drug in the early morning, magnesium and iron preparations should be used, as well as dairy products (due to their calcium content) should be taken only after dinner or in the evening. The simultaneous use of the medication can easily enhance the effect of insulin, as well as oral hypoglycemic drugs. We can not say that ethanol significantly reduces the therapeutic activity of alpha-lipoic acid.
Special instructions for the use of a medical product
Those patients who take the drug "Tieolepta", at the time of treatment, it is necessary to refrain from drinking alcohol-containing drinks.
As for patients with diabetes mellitus, then during the treatment period they need regular monitoring. In such patients, it is necessary to constantly check the concentration of glucose in the blood. This is especially necessary to do at the initial stage of treatment. In some cases, it is required to reduce the dosage of insulin or oral hypoglycemic agents. This is necessary in order to avoid the development of hypoglycemia.
The drug "Tilept": analogues and the cost of the drug
After prescribing this drug, the patient is often interested in the question of how much it costs. Currently, this medication can be purchased at different prices. It depends not only on a particular pharmacy network and product margins, but also on the form of release of the drug and its quantity in the package.
So what is the cost of the Tielept drug? The price of this drug varies between 600-700 Russian rubles for 30 tablets (600 mg). If you need a lower dosage, then you can buy the same amount of medicine for 300-400 rubles (300 mg).
Now you know how much the Tieolept 600 medicine costs. The price of this medicine is quite high. It is this fact that prompts many patients to replace the drug with cheaper analogues. The following medications can be attributed to them: “Lipoic acid”, “Neuro lipon”, “Lipothioxone”, “Okolipen”, etc.
What else can replace the Tielept drug? Analogs of this tool can be not only cheaper, but also more expensive than the original. Such drugs include the following: Alpha Lipoic Acid, Lipamide, Beplition, Thioctic Acid, Thiogamma, Thiolipon, Thioctacid, Espa-Lipon, etc.
It should be especially noted that only an experienced specialist should replace the prescribed Tieolept medication with analogues. This is due to the fact that these drugs can have completely different side effects, contraindications and dosages.
Storage methods
Keep the drug “Tieolept” should only be in a cool and darkened place, where there is no access for small children. The shelf life of this medication is two years for tablets and three years for a solution.
Drug Reviews
What do patients say about a medication such as Tielept? Reviews about this drug are more positive. According to patients, the Tielept medication is an excellent remedy for pain in the back and lower extremities. Very often, this drug is prescribed to patients after surgery for diabetes. This remedy really helps to stand up, as 40% of patients with diabetes have pathologies of peripheral nerves.
The medicine “Tieolepta” helps to eliminate pain syndromes and alleviate the condition of patients, especially when overweight.
It can not be said that this medication is often prescribed as a complex treatment of liver cirrhosis.
As for the negative reviews, the drug Tieolept also has them. In most cases, they are associated with the fact that after taking the tablets or using injection solutions, patients experience side effects in the form of nausea, severe heartburn and vomiting. Moreover, some patients claim that this drug does not give any result at all. As a result, patients are forced to re-apply to specialists so that they prescribe them a more effective and effective drug.