Ciprofloxacin is the main active element of the medicine “Tsiprobay”, which is characterized by a high degree of antibacterial activity.
The considered pharmacological agent is active against many gram-negative and gram-positive pathogens. The bactericidal property of the active substance is due to the suppression of bacterial topoisomerases of type II (topoisomerase IV and topoisomerase II), without which the process of replication, transcription, repair and recombination of bacterial DNA is impossible.
Indications for use
According to the instructions for use with Ciprobay and other ciprofloxacin-based agents, they are prescribed for the treatment of uncomplicated and complicated infections that are provoked by microorganisms that are sensitive to ciprofloxacin and affect the urinary tract, eyes, kidneys, joints, genitals, bones, abdominal cavity (including peritonitis, bacterial diseases of the biliary tract or digestive tract), soft tissues, skin. Also, drugs are used in the treatment of respiratory tract infections - they are recommended for pneumonia caused by Haemophilus spp., Enterobacter spp., Staphylococcus spp., Legionella spp., Branhamella spp., Klebsiella spp., Escherichia coli, Proteus spp., Pseudomonas spp. Sinusitis, otitis media, otitis media, gonorrhea, sepsis, infections in people with weak immunity, selective intestinal decontamination, anthrax in pulmonary forms are treated with the medicine “Tsiprobay” and its analogues.
Contraindications
As the instructions for use for “Tsiprobay” indicate, absolute contraindications are:
- combined use simultaneously with tizanidine (associated with an increase in the plasma concentration of the latter in the blood and the emergence of clinically significant negative reactions, for example, drowsiness, hypotension);
- age less than 18 years, with the exception of cases of treatment of some complications of cystic fibrosis in the lungs and the prevention of anthrax;
- pregnancy, lactation process;
- individual intolerance;
- hypersensitivity to fluoroquinolones.
Relative contraindications can be considered:
- pathologies of the central nervous system (epileptic seizures, decreased level of convulsive readiness or severe history);
- restriction of blood flow in the cerebral vessels, stroke or organic damage to the brain;
- hepatic and renal failure;
- mental disorders: psychosis, depression;
- elderly age.
Admission rules and dosage instructions
The medicine "Tsiprobay" and analogues of the drug based on ciprofloxacin are taken orally, on an empty stomach, washed down with water, regardless of food. It is undesirable to drink tablets with milk or liquids enriched with calcium. If it is impossible to take this medication inside, it is prescribed in the form of infusion solutions. After normalizing the patient's condition, they are transferred to the administration of the drug orally.
The infusion solution is administered intravenously into a large vein, the duration of infusion is at least 1 hour. The medicine can be administered in combination with other compatible solutions. Adults are recommended the following dosage regimen:
- respiratory infections - 500 mg of “Tsiprobay” 2 times a day;
- diseases of the urinary tract of a complicated nature - 250 or 500 mg 2 times;
- bladder inflammation - once 250 mg;
- extragenital gonorrhea - 130 mg 2 times;
- uncomplicated gonorrhea - once 250 mg;
- diarrhea –2 times a day, 500 mg each;
- other infectious diseases - 500 mg 2 times;
- anthrax - 2 times a day for 500 mg;
- infectious pathologies that threaten life (septicemia, peritonitis, streptococcal pneumonia, diseases of the joints and bones) - 2 times a day, 750 mg each.
Drug cost
The price of “Tsiprobay” may vary depending on the pharmacy network that implements it and the dosage of the medication, and ranges from 240 to 420 rubles per package. The cost depends on the region.
Analogs "Tsiprobay"
Structural analogues of the drug are:
- "Afenoxin";
- Betaciprol;
- Basidzhen;
- Vero-Ciprofloxacin;
- Ififpro;
- Zindolin;
- Quintor;
- "Liprokhin";
- Quipro;
- Microflox;
- Oftipipro;
- "Nirzip";
- Syflox;
- "Tsiloksan";
- “Tseprova”;
- Ciprinol;
- "Tsiprobid";
- Tsiprodoks;
- "Cyprobrin";
- "Tsiprolaker";
- Tsiproksil;
- "Tsiprolet";
- "Tsiprolon".
Consider some drugs in more detail.
Zindolin
Broad-spectrum antimicrobial drug derived from fluoroquinolone. The drug is able to suppress bacterial DNA gyrase (topoisomerases II and IV, which are responsible for the supercoiling of DNA chromosomes around the RNA of the nucleus, which is necessary for reading information), disrupts DNA production, division and bacterial growth. In addition, the medication causes significant morphological transformations (including membranes and cell walls) and the rapid death of pathological cells.
It acts bactericidal on gram-negative organisms at rest and division (since it has a pronounced effect not only on DNA gyrase, but also promotes lysis of the cell wall), on gram-positive microbes - only during division.
Low toxicity is explained by the absence of DNA gyrase in the cells of the body. During treatment with ciprofloxacin, there is no concomitant resistance to other antibiotics that are not classified as gyrase inhibitors, which makes it most effective against microbes that are resistant to aminoglycosides, cephalosporins, penicillins, tetracyclines and other medicines.
What other analogues of Tsiprobay are known?
Ififpro
This medication is an absolute structural analogue of the medication, and is based on the same active element - this is ciprofloxacin.
This drug is highly effective against almost all types of aerobic bacteria, indole-negative and indole-positive microorganisms: Proteus spp., Enterobacter spp., Morganella morganii, Hafnia spp., Providencia stuartii, Salmonella spp., Citrobacter spp., Vibrio cholerae, Yersinia enteroliba parahaemolyticus, Moraxella catarrhalis, Neisseria meningitidis, Neisseria gonorrhoeae, Providencia spp., Haemophilus influenzae, Pseudomonas aeruginosa, Acinetobacter anitratus, Pasteurella multocida, Shigella spp., Campylobacter s. etc.
A medication is prescribed for almost any infectious pathology, including in severe forms. Their list includes diseases of the respiratory organs, gynecological problems, diseases of the urinary system, musculoskeletal and articular apparatus, purulent lesions, peritonitis, sepsis.
Analogs "Tsiprobaya" should choose a doctor.
Lyprokvin
The pharmacological effect of this agent is antibacterial, the main element is ciprofloxacin. Suppresses DNA gyrase, disrupts biological DNA synthesis, division and growth of bacteria. It acts on microbes during dormancy and growth. Quickly absorbed from the gastrointestinal tract in the small and duodenum. It penetrates into tissues, cells and fluids, creating a high concentration in the kidneys, liver structures, ducts of the gallbladder, lungs, mucous membranes of the sinuses and bronchi, genitals, urine, phagocytic cells, bile, sputum, is found in the prostate, spinal saliva, fluid, fat tissue, skin, bones, muscle fibers, passes through the placenta. It breaks down in the liver, excreted by the kidneys with urine.
Reviews
There are many positive reviews about the drug “Tsiprobay” and its analogues based on the substance ciprofloxacin, due to its high effectiveness during the treatment of infectious diseases and complications.
Patients note that they used this medication for serious inflammation of the respiratory organs, urinary system, digestive system, reproductive system, joints.
The medicine, according to patients, is tolerated normally, does not cause severe disturbances in the general condition, as well as symptoms of dyspepsia. The condition of patients does not normalize immediately, approximately on the fifth or seventh day of therapy in case of serious diseases, and on the third or fourth - in conditions of moderate complexity.
This medicine is not prescribed for children, however, there is information in the reviews that the medicine was used for life-threatening diseases in children after 10 years. Dosages were calculated by specialists in accordance with the body weight of the child and the characteristics of the disease.
Experts do not recommend using the medication in question on their own, it is best to get the advice of a doctor.