Stressful conditions occur in adults quite often, but they are usually associated with everyday problems and are eliminated by regular rest, a change of scenery or light natural preparations. In cases of more complex depressive situations, doctors can prescribe the patient "Amitriptyline Nycomed" (25 mg), the instructions for use of which are described below.
Indications for use
"Amitriptyline Nycomed" (25 mg) has indications for use as follows:
- autism;
- hypochondria;
- depression;
- schizophrenic psychosis;
- bulimia nervosa;
- bed-wetting;
- chronic pain syndromes;
- peptic ulcer disease;
- migraine prophylaxis.
Among the entire list of serious nervous disorders, it should be noted that the drug is prescribed by specialists even for patients with cancer, in order to reduce pain. In case of violation of the emotional state and behavior, increased anxiety, sleep disturbances and neglected depression, the remedy helps 100%, it is important to remember only that it does not start acting immediately.
Analogs and cost
"Amitriptyline Nycomed" (25 mg) in tablets in stationary pharmacies costs about 50-70 rubles per pack. Also, the medication is available in the form of solutions for injection and infusion.
Amitriptyline (25 mg) is produced in tablet form by many companies under the same name.
So, analogues of the drug from the pharmaceutical company "Nycomed" are medicines from manufacturers:
There is also a cheaper version of domestic production and tablets called "VERO-AMITRIPTILINE", produced by many pharmacological foreign companies.
Drug pharmacology
"Amitriptyline Nycomed" (25 mg) describes the description as the strongest antidepressant of the tricyclic group. When a doctor prescribes this drug for use, it is very important to remember that its effect is fully observed only 2-3 weeks after the start of therapy.
A decrease in the depressive state in patients is often observed much earlier than the stated period and is due to an increased concentration of norepinephrine in the body. After a few days, anxiety begins to completely disappear, and after a couple of weeks the psychological state is completely stabilized and the agitation goes away. The equilibrium of the nervous system is also restored due to the normalization in the body of the level of serotonin and β-adrenergic receptors.
"Amitriptyline Nycomed" (25 mg) instructions for use and describes as an effective tool against severe pain syndromes. Its analgesic effect is also associated with the normalization of serotonin levels in the body. Also, the drug normalizes the amount of monoamines in the nervous system.
In addition, the drug has a pronounced sedative effect and is able to block acetylcholine in the blood of patients. This often leads to confusion during therapy, dizziness, visual impairment, dry mouth, constipation, or difficulty urinating. All these effects are indicated in the instructions for the drug as possible side effects. By the way, it is thanks to them that the medicine is prescribed as effective for nighttime urinary incontinence, because it is the blocking of acetylcholine that allows the bladder to stretch more, while increasing the sphincter tone.
From what tablets "Amitriptyline Nycomed" (25 mg) help more? Peptic ulcer of the stomach or duodenum is necessarily added to this list. The effectiveness of the drug in the treatment of these ailments is due to its ability to block histamine receptors and have a sedative effect. This is what helps patients not only to reduce pain, but also to accelerate the healing of ulcers existing on the mucous surface of the internal organs.
It is interesting that the effectiveness of the drug in bulimia is not explained in any way by its pharmacological properties, but it remains obvious. Amitriptyline Nycomed (25 mg) helps patients with this diagnosis, even without pronounced signs of depression. The mechanism of action is most likely due to the antidepressant properties characteristic of the drug.
It is important to know that Amitriptyline Nycomed (25 mg), the instructions for which are included in each pack, can significantly reduce blood pressure, body temperature and even slow down breathing when the dose is exceeded or during anesthesia. That is why the use of the drug should be discontinued several weeks before the planned operations and be sure to warn specialists about the list of drugs used.
The drug does not cause blocking of the cleavage of monoamine oxidase.
Pharmacokinetics of tablets
Once in the patient’s body, Amitriptyline (25 mg) binds to plasma proteins by 80-96%, depending on secondary conditions. Its bioavailability is about 50%, and the half-life is from 30 to 45 hours. Removal of drug residues is carried out mainly by the kidneys.
Instruction manual
"Amitriptyline Nycomed" (25 mg), instructions for use recommends starting with the lowest dose for all categories of patients and regardless of diagnosis. The dosage in this case is prescribed by the attending physician from 25 mg to 50 mg per day at a time before bedtime. Only after using the drug in this mode, its daily amount gradually increases, depending on the disease, to a maximum of 200 mg. Most of the recommended amount of the drug is also taken at night.
Only in the absence of a visible effect for several weeks from the drug "Amitriptyline" the use is allowed to be increased with an increase in the daily dose to 300 mg. This happens very rarely and only in special cases.
Immediately after the disappearance of visible signs of depression or other nervous disorders, the dosage of the drug is reduced to the minimum (50-100 mg) and treatment is continued until the end of the course prescribed by the doctor. Usually, therapy with this drug lasts several months. It is important to know that in old age, due to the risk of side effects of Amitriptyline Nycomed (25 mg), the instruction confirms this, should be taken in the active phase with a maximum dosage of 100 mg, and with the disappearance of visible problems - 50 mg and only night.
Incontinence of children is treated with the drug only from the age of six, since it is forbidden to give it to children earlier. The dosage in this case is 10-20 mg in children under 10 years old and 25-50 mg - up to 16 years.
"Amitriptyline" can be used as an injection to treat various diseases, but the contraindications and dosage are calculated in a completely different way.
Bans to use
"Amitriptyline Nycomed" (25 mg) has many contraindications, because it is characterized as a very strong antidepressant.
In addition to the individual intolerance to any of the components of the drug, it is forbidden to use:
- during gestation and lactation;
- children under six years old;
- during the recovery period after a heart attack;
- with angle-closure glaucoma;
- with severe heart disease;
It is also strictly forbidden to take together "Amitriptyline", alcohol, psychotropic, analgesic and sleeping pills.
Side effects
Since Amitriptyline Nycomed (25 mg) is described as a potent antidepressant, the list of its possible undesirable effects is very wide. Despite this, according to reviews, in most patients they do not occur at all or only dizziness appears in the first days after the start of therapy.
So, the drug can cause disorders from:
- nervous system;
- digestive
- cardiovascular;
- endocrine;
- hematopoietic.
Also, "Amitriptyline", the instruction contains a complete list of side effects, can cause various allergic reactions to the skin in the form of rashes, swelling or itching. In addition, in some patients, hair loss, swollen lymph nodes, and tinnitus were noticed during studies.
Among the most common side effects, patients distinguish characteristic manifestations of anticholinergic activity. These include just dizziness, dry mouth, tachycardia, confusion, in special cases hallucinations are possible.
Digestive system disorders such as nausea, changes in taste perceptions, impaired appetite, heartburn, stomatitis, diarrhea are less common. Very rarely, hepatic impairment and hepatitis are manifested in this direction.
On the part of the thyroid gland, breast enlargement in women and a violation of potency in men can be observed. A common effect for any gender is a decrease in libido. In the work of the heart, arrhythmias, tachycardia, dizziness, nonspecific indicators during an electrocardiogram and so on can be manifested.
Particular attention should be paid to the list of possible negative manifestations of the nervous system. Despite the fact that the drug is aimed specifically at its stabilization, most of the risk of side effects is also associated with it.
So, patients may experience:
- anxiety;
- drowsiness;
- increased depression;
- fainting
- manic states;
- disorientation;
- psychosis;
- headaches;
- insomnia;
- nightmares in a dream;
- increased seizures of epilepsy.
Interaction with other drugs
It is very important for all patients to remember, even if depression was exhausted before exhaustion: "Amitriptyline" should not be taken with other additional drugs that have a depressing effect on the nervous system. Such an overdose can lead to respiratory depression and a sharp decrease in blood pressure. Attention should also be paid to all drugs used in parallel with an anticholinergic effect, which can be significantly enhanced.
The negative effect in the form of tachycardia, cardiac arrhythmias, inhibition of metabolism and other undesirable effects is also amplified while taking with other antipsychopathic medicines.
During the first days of parallel therapy, along with ethanol, its effect will be pronounced in patients. In some cases, this effect persists throughout the entire course of administration. "Amitriptyline Nycomed" (25 mg), instructions and patient reviews indicate this, enhances the action of other chemicals. So, concomitant use with antihypertensive drugs can provoke a risk of orthostatic hypotension.
Despite the fact that the medication in question does not apply to MAO inhibitors, taking it in parallel with similar drugs can be dangerous to health. This combination of active substances can provoke a hypertensive crisis in the body.
Certain substances can reduce the effectiveness of amitrimpiline, while others, on the contrary, increase its concentration in the blood so much that a toxic reaction can occur in patients. That is why such a serious drug should be taken only after consulting a specialist. An experienced doctor is always able to prescribe the correct dosage and take into account the interaction of the drug with other drugs taken.
Additional recommendations
Amitriptyline has a very wide list of possible side effects and contraindications, but it can become even broader if you do not take into account certain recommendations. So, the drug should be taken with caution in chronic alcoholism, because the drug is, in principle, incompatible with alcohol. In addition, it is necessary to consider the presence in patients of arrhythmia, arterial hypertension, heart failure, or the active phase of thyroid therapy during the appointment of the drug.
Patients undergoing Amitriptyline therapy should take into account that the active substance can cause turbidity during a sharp transition to an upright position, so you should always get up smoothly. Also, with a long period of therapy and a sharp cessation of treatment, most develop withdrawal symptoms.
Since the drug is incompatible with drugs that inhibit MAO, they should begin therapy no earlier than 2 weeks after stopping the above drugs.
Doctors should always be warned about taking this medication, precisely because it is able to affect the effect of other medicines. It is also necessary to exclude simultaneous administration with ephedrine, phenylephrine and similar substances.
In elderly patients, especially those who observe bed rest and have little movement, the drug can cause acute intestinal obstruction. Any complex effect on the body in the form of electrotherapy is allowed only under the strict supervision of doctors.
Long-term use of the drug can cause tooth decay and the need for additional consumption of riboflavin.
If the medication is prescribed to the patient in a daily dosage of more than 150 mg, then it is likely that the concentration of the substance in the body will provoke a further increase in epileptic seizures and a vivid manifestation of convulsive syndrome in other symptoms. With prolonged use, it is also necessary to consider that patients may have suicidal tendencies, especially with a sharp discontinuation of the drug.
Application under certain conditions
At any age, patients should avoid driving vehicles and complex mechanisms during therapy. The fact is that “Amitriptyline” is able to depress a person’s attention and reduce the speed of his psychomotor reactions.
In childhood, the medication is used only from the age of 6 years in the form of tablets. Injection fluids are subject to even greater restrictions. They can be used for children only from the age of 12 years.
During pregnancy, the drug is prohibited to take, because, according to research, it can have a negative effect on the development of the fetus. The use of the medication is allowed in very rare cases and only in the second trimester, if the benefit completely covers the possible harm. It is also necessary to stop therapy in time so that the baby does not develop withdrawal syndrome after birth. The drug should be discontinued at least 7 weeks before the expected date of birth.
During feeding, Amitriptyline Nycomed is not used at all, as it can cause drowsiness and addiction in children.
In elderly patients, the drug often causes intestinal obstruction, which should be removed symptomatically or by replacing the drug with another. Also in old age, there may be drug psychoses, which most often occur after discontinuation of the drug at night.
Reviews
"Amitriptyline Nycomed" (25 mg) reviews of experienced patients collects mixed. Most of those undergoing treatment with this medication were completely satisfied with the result and noted only slight dizziness during therapy. The low price, which is available to any person, is especially distinguished among the advantages of the medication, especially when considering that the course of treatment lasts about several months. In general, even taking into account some negative characteristics, absolutely everyone notes its effectiveness. The drug helps patients in a short time to get rid of the strongest mental disorders and again return the joy of life.
Among the minuses of the tablets, reviews note side effects. Of course, most indicate that they pass over time, but in some cases this is not so. If the patient does not stop pestering additional negative manifestations from taking the medicine, then it is necessary to consult a doctor so that he replaces it with another remedy.
Of course, negative reviews are most often found from those people who decide to take the medicine on their own, because it is sold without a prescription from a doctor. It is from the incorrectly calculated dose that they have problems. According to reviews from doctors, any negative manifestations can be avoided by correctly considering the individual characteristics of the body and the patient’s diagnosis.
Conclusion
Many believe that you can get a quality medicine, especially against severe disorders, only at a sky-high price. Amitriptyline completely refutes this statement and helps all patients quickly and effectively cope with any depression for little money. Of course, taking it on your own is not recommended, since an incorrect dosage calculation can provoke intoxication of the body and increase the risk of side effects.
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