"No-spa" intramuscularly: instructions for use, purpose, dosage, composition, indications and contraindications

How to apply "No-shpa" intramuscularly? We will understand in this article.

The medication “No-shpa" is a drug based on the substance drotaverine, which is produced in the form of tablets and ampoules. The drug gives an antispasmodic effect and is used in the treatment of spastic digestive tract syndrome, reproductive, hepatobiliary and urinary systems. In addition, this medication relieves spasms of cerebral vessels in case of headaches resulting from overstrain as a result of depression and neurosis, and peripheral vessels in Raynaud's disease or endarteritis.

The active substance is a derivative of papaverine. The generic international name for the No-Shpa drug is Drotaverin. According to the clinical and pharmacological classification, it is classified as myotropic antispasmodics. By its properties, the substance is very similar to papaverine, however, it has a longer and more pronounced relaxing effect on muscle fibers.

The effectiveness of the pharmacological agent is due to its ability to exert a depressing effect on the enzyme phosphodiesterase, which, through a series of chemical reactions, is capable of catalyzing the inactivation of the kinase of myosin chains. This kinase phosphorylates myosin and provokes muscle contraction. When it is stopped, muscle relaxation is supported. The positive properties of the drug also lie in the selective suppression of PDE of only the fourth type, which does not affect the enzyme of the third type and does not cause negative side effects from the vessels and heart.

Drotaverinum causes muscle relaxation in case of spasms of both neurogenic and myogenic origin and, regardless of the type of innervation, relaxation of muscle fibers. A significant advantage of this medication is that there is no stimulating effect on the cholinergic system, as a result of which the No-Shpa medicine can be used in people suffering from a disease such as glaucoma. However, some caution must be exercised when taking it, especially if there is prostatic hypertrophy, as it may cause symptoms of urinary retention due to relaxation of the detrusor in the bladder. So "No-spa" is intramuscularly prescribed very often.

Composition and form of release

The “No-shpa” medicine for intramuscular administration is made in glass ampoules in which there are 2 ml of injection solution. The volume of the active element in 1 ml is 20 mg of drotaverine. Injections can be carried out by intra-arterial, intravenous and intramuscular administration. The solution has a bright yellow-green color.

Indications for appointment

Indications for the use of the pharmacological agent "No-spa" intramuscularly are the prevention and therapy of organ functional disorders and pain caused by:

• muscle spasms of the digestive tract with ulcers, gastritis, dyskinesia, pancreatitis, spastic enteritis, proctitis or colitis, as well as spasm of the pylorus or cardia, irritated intestines, flatulence, spastic constipation, tenesmus;
• a violation of the functionality of the hepatobiliary system in inflammatory processes in the gallbladder or its ducts, hyperkinetic forms of biliary dyskinesia, gallstone disease;
• excessive excitability of the uterus during pregnancy;
• spasms of the urinary system with the development of kidney stone disease, pyelitis, urolithiasis, neurogenic bladder, pyelonephritis, cystitis;
• cramping uterine throat during the birth process;
• prolonged opening of the uterine pharynx;
• postpartum contractions;
• the threat of spontaneous miscarriage;
• menstruation.

This is indicated in the instructions. “No-spa" is also used intramuscularly in case of spasms of cerebral and peripheral vessels. Effective in postoperative colic due to gas retention, preparation for instrumental studies, postcholecystectomy syndrome.

The use of No-Shpa injections for children

Children under six years of age are not allowed to inject the drug intramuscularly. It is important to know that the main substance of the drug is synthesized artificially. In other words, it is not a natural element. Therefore, children "No-shpu" intramuscularly usually used only as directed by a specialist.

The medicine is a good antispasmodic, but does not have a pain-relieving effect, such as Analgin and similar drugs. In addition, it has some contraindications for use, they should also be considered when treating children.

The instruction for use for No-Shpa injections reports that usually this medicine is prescribed for small patients in the following cases:

• White fever in children, which is accompanied by high fever and coldness of the limbs.
• Cramping in bronchitis or stenosis, causing severe coughing.
• Cramps provoking a headache.
• Renal or intestinal colic.
• Excessive painful gas formation.
• Spasm of smooth muscles with pyelitis or cystitis.
• Cramping with gastritis or colitis.

Contraindications for the use of No-Shpa injections for children are:

• age up to 6 years;
• low blood pressure in a child;
• drotaverin intolerance;
• vascular disease;
• bronchial asthma;
• suspected intestinal obstruction;
• suspicion of acute appendicitis;
• failure of the liver, kidneys.

In accordance with the instructions for use, No-Shp injections can be administered during pregnancy.

Pregnancy

Among the medications that are widely used during pregnancy, No-shpa plays a special role. Being a powerful antispasmodic, this medicine eliminates any pain associated with a temporary violation of the digestive tract in expectant mothers. In addition, during pregnancy, this medication is absolutely safe, it can be used without any fear.

However, even taking into account these properties of the drug, caution should be exercised when using it during this period, since there are certain indications for it, contraindications and negative side reactions.

During pregnancy, No-Shpa can be administered intramuscularly for uterine hypertonicity and the threat of premature birth. At the first symptoms of a premature birth or the threat of spontaneous miscarriage, such as pulling pain in the lower abdomen and a feeling of fullness in this area, a single use of No-Shpy in most cases completely eliminates uterine hypertonicity and helps to maintain pregnancy.

Another indication for the use of this pharmacological drug is a spasm of the smooth muscles of the uterus and cervix during childbirth. This situation is dangerous because the child is in a clamped state - excessive muscle tension of the myometrium contributes to expelling him from the uterus, however, the contracted cervix prevents him from moving through the birth canal. In most cases, one dropper with this drug solution is enough to restore the normal birth process. The dosage of "No-shpa" intramuscularly should be strictly observed.

Contraindications

• The main contraindication to the use of this drug, like many other drugs, is the manifestation of severe disorders of the liver, kidneys, heart, due to the insufficiency of their functions.
• In addition, the No-Shpa drug is not prescribed during breastfeeding, as drotaverin and other representatives of this pharmacological category can penetrate into breast milk.
• The use of the drug is allowed from the age of 6, but only in tablet form, since studies of the effects of injection solutions have not been conducted, according to which the use of the drug is parenteral contraindicated.
• Taking the medication is contraindicated in the presence of high sensitivity to the active element or other substances from its composition.
• This drug can be used only with certain precautions with low blood pressure due to the high likelihood of collapse, as well as during pregnancy.

What is the dosage of No-Shpa intramuscularly?

Dosage regimen and methods of administration

A single dosage of No-Shpa medicine in the form of solutions for intramuscular, intra-arterial and intravenous administration, depending on medical indications, is 1-2 ampoules. The frequency of such injections is 1-3 times a day. How to enter "No-shpa" intramuscularly, is indicated in the instructions.

During labor or after an abortion, administration of the drug in the amount of 80 mg with an interval of at least 2 hours is allowed. How long does No-Shpa act? Intramuscular and intravenous injection allows you to get the desired result after 5 minutes. That is why injections of this medication are widespread.

Side effects

Negative adverse reactions that may occur when using this pharmacological drug develop extremely rarely. Most often, its effect adversely affects the nervous system, gastrointestinal tract, blood vessels and heart.

1. Nervous system: cephalalgia, dizziness, sleep disturbance.
2. Circulatory system: increased or rapid heartbeat, a feeling of heat, a disturbance in the rhythm of the heartbeat, a decrease in blood pressure (sometimes up to the onset of collapse), and atrioventricular blockade.
3. Digestive system: dyspeptic symptoms, nausea, impaired stool.

In addition to the above negative effects of this medication, there is some information about such side effects as respiratory failure, excessive sweating, allergic reactions. Locally, redness or a burning sensation is possible. Most often this is manifested when the dosage of “No-shpa” injections is not observed.

Special recommendations

There are also special instructions that should be strictly adhered to when using the No-Shpa medicine:

1. It is necessary to observe increased caution in the treatment of patients who suffer from coronary artery atherosclerosis or low blood pressure.
2. The medicine is approved for use in the treatment of hypertensive crisis.
3. The issue of driving a vehicle when using a medicinal product is decided on an individual basis, especially when its negative effects occur. In this case, it is advisable to abandon driving and activities involving the use of complex mechanisms when using antispasmodics in injection forms. If dizziness occurs after the introduction of “No-shpa”, it is forbidden to perform the indicated types of work intramuscularly.
4. According to clinical studies, this medication does not have embryotoxic or teratogenic effects. Nevertheless, it is necessary to remember the possible risk to the fetus and use the medication only for strict medical reasons with the observance of caution. The use of drugs during pregnancy in the form of injections is undesirable.
5. The use of antispasmodics during labor can cause the development of postpartum atonic bleeding.
6. The pharmacological agent contains metabisulfite (sodium disulfite) as an auxiliary element, which must be taken into account in the presence of hypersensitivity to it.
7. With the parenteral administration of this medication, patients suffering from hypotension should take a horizontal position of the body due to the high probability of collapse.

What else does the instruction for No-shpe tell us (intramuscularly)?

Drug interaction

Drotaverine, like other papaverine derivatives that inhibit PDE enzymes, can lower the antiparkinsonian properties of levodopa, as well as increase muscle stiffness and tremor. With simultaneous therapy with other antispasmodic medical agents, mutual potentiation of antispasmodic effects may be observed. This injectable pharmacological drug enhances the decrease in blood pressure provoked by the use of antidepressants, quinidine, or procainamide. This is confirmed by the instruction for the use of No-Shpy injections intramuscularly.

This medication reduces the spasmogenic effectiveness of morphine. When using phenobarbital, there is an increase in the antispasmodic effect of the No-Shpa drug. Given the high level of binding to plasma proteins (more than 80%), the likelihood of competition of this medication with medicines that have the same feature is not excluded. Given this fact, in the case of the use of a combination of such drugs, it is possible to enhance the toxic effect of the drugs taken.

Analogs

The No-Shpa medical product in the form of injectable solutions has many analogues that have the same composition, but different bioequivalence and bioavailability. These medicines include:

1. "Nosh-bra" is a medicine from the category of myotropic antispasmodics. By pharmacological properties and chemical structure, it is close to papaverine, however, it has a longer and stronger effect. Reduces the level of calcium ion entry into smooth muscle cells (inhibits phosphodiesterase, promotes the accumulation of intracellular cAMP). Reduces muscle tone of organs and peristalsis, dilates blood vessels. It does not affect the autonomic nervous system, does not penetrate the central nervous system. The presence of a direct effect on smooth muscle allows the use of this drug as an antispasmodic in situations where class M-anticholinergic drugs are contraindicated (prostatic hyperplasia, angle-closure glaucoma).
2. "Spazmol" is a medicine that is an antispasmodic of myotropic effects. A distinctive feature of this pharmacological drug is the presence of a lasting effect. The medicine affects not only the smooth muscles of internal organs, but also on the walls of blood vessels. You can take it to prevent the development of spasms or their presence in colitis, cholelithiasis, to eliminate spasms of the digestive tract, brain, in order to reduce uterine tone, dilate blood vessels, and reduce peristalsis in the intestines.
3. "Spakovin" is an antispasmodic of myotropic effectiveness, similar in properties to papaverine, but surpassing it in effectiveness and duration of exposure. Reduces the tone of internal organs, their motor activity and has a vasodilating effect.

Other analogues of the medication "No-shpa" are:

• "Drotaverine hydrochloride";
• "Papaverine";
• Drotaverin Forte;
• Spazgan
• "Cuplaton";
• Niaspam
• "Spasmolysin";
• "Disflatil";
• Kidakol
• “Nohhh”;
• "Spasmomen."

Price

The cost of this drug in the form of ampoules No. 5 is from 70 to 190 rubles per pack, in the form of ampoules No. 25 - up to 320 rubles. It depends on the region and the pharmacy network.

Reviews about injections "No-shp"

Reviews about this drug are mostly positive. This is due not only to the high effectiveness of the medication, but also to the fact that it has been known for several decades as a good antispasmodic with various disorders in the body.

Patients say that No-shpa is one of the remedies that is always available in a home medicine cabinet. After its administration, painful sensations that are associated with the development of spasms quickly pass, and this effect is observed by patients for approximately 20 minutes. It was used by patients who left reviews, most often with the development of intestinal colic, cephalgia of vascular origin, with pain in the right hypochondrium associated with a violation of the outflow of bile.

Specialists also characterize this pharmacological drug as a highly effective antispasmodic, time-tested, and indicate its high safety, which helps to use this medicine even in the treatment of pregnant women. However, they do not recommend the use of intramuscular injections without medical indications and recommendations, since this must be done very carefully. At home, a tablet form of this medication is usually used.

We examined the instructions for use with No-Shpe intramuscularly.