In the article, we consider the instructions for use and price for the Natecal D3 preparation.
Diseases that are accompanied by a deficiency of calcium and cholecalciferol require the appointment of such a combined drug to patients. If it is taken, the torus normalizes the exchange of phosphorus and calcium, bone density increases, the body is provided with the necessary calcium content. In addition, the drug regulates the production of parathyroid hormone, which affects the metabolism of calcium and stimulates high bone resorption.
Release form, packaging and composition
According to the instructions for “Natekal D3”, these are chewing flat round tablets of almost white or white color, the edges are beveled, the smell is specific, on one side is the D.
One tablet contains 400 IU of cholecalciferol (D3), which corresponds to four milligrams of vitamin D3 in dry form (corn starch, sucrose, gelatin, soybean oil hydrated, alpha-tocopherol acetate), 1.5 grams of calcium carbonate, which is equal to 600 milligrams of calcium .
Auxiliary components: magnesium stearate, sorbitol, molasses flavoring, maltodextrin, mint flavoring, croscarmellose sodium, anise flavoring, aspartame, lactose monohydrate, sodium saccharin.
Sold in plastic bottles and cardboard packs of twelve or sixty pieces.
Pharmacological effect
As we are told by the instruction for “Natekal D3”, this is a combination agent that regulates the exchange of calcium and phosphorus in the body. Reduces resorption and helps increase bone density, eliminates the deficiency of cholecalciferol and calcium in the body (vitamin D3).
Vitamin D3 (cholecalciferol) increases the absorption of calcium from the gastrointestinal tract and its binding in bone tissue. The use of the drug prevents the synthesis of parathyroid hormone, which stimulates high bone resorption.
Cholecalciferol is absorbed from the small intestine, while the ionized form of calcium is absorbed from the proximal portion of the small intestine using an active transport mechanism dependent on vitamin D3.
Indications and contraindications
As indicated by the instructions for use, Natekal D3 as a prophylactic and therapeutic agent is used for:
- complex treatment and prevention of osteoporosis (including idiopathic, steroid and senile) and its complications (bone fractures);
- supplementing the lack of vitamin D3 and calcium in elderly patients.
It is recommended for the prevention of calcium deficiency.
As written in the instructions, "Necal D3" is contraindicated in:
- hypercalcemia (including with hyperfunction of the parathyroid glands);
- urolithiasis (the formation of calcium stones);
- hypercalcemia;
- tumor metastases in the bone;
- sarcoidosis;
- osteoporosis caused by prolonged immobilization;
- phenylketonuria;
- active form of pulmonary tuberculosis;
- an overdose of D3;
- intolerance to varieties of sugars (including fructose, sorbitol, sucrose, lactose);
- increased sensitivity to the composition of the drug (including soy and peanuts).
The drug is used with caution in benign granulomatosis and renal failure.
Dosage
In accordance with the instructions to "Natekal D3", before using the drug, it is necessary to consult a specialist.
The tablet is absorbed or chewed (it should not be swallowed completely). Adult patients are prescribed one or two tablets per day, mainly during food intake.
The drug is used to compensate for the lack of vitamin D3 and calcium, the treatment of osteoporosis in elderly patients. The duration of the therapeutic course and dosage regimen is set in accordance with medical recommendations.
Side effects
Side effects from the digestive system are as follows:
- diarrhea;
- stomach ache;
- constipation;
- nausea;
- flatulence.
Other symptoms: allergic reactions, hypercalcemia. What else does the instructions for use for Natekal D3 tell us?
Overdose
If the drug is used in large doses, it causes more frequent urination, nausea, dry mouth, vomiting, headache, loss of appetite and dizziness. With a strong overdose, a person can lose consciousness and even fall into a coma. Prolonged use of the drug in doses that exceed the norm can lead to the occurrence of calcification of blood vessels and soft tissues.
Natekal D3 lacks a specific antidote. In case of an overdose, medical care consists in the fact that the patient is prescribed diuretics, calcitonin, glucocorticosteroids and bisphosphonates. Also at this time, the patient is recommended a diet. It is important to exclude foods that contain vitamin D3 and calcium from your diet.
We will consider the price and reviews of Natekal D3 below.
Drug interaction
If Natecal D3 is used simultaneously with barbiturates or phenytoin, the activity of cholecalciferol decreases. Use along with cardiac glycosides enhances the effect of the latter due to calcium, which is part of Natekal D3. That is why such a combination requires constant monitoring of the patient’s clinical condition and ECG.
With simultaneous use with tetracycline antibiotics, cholecalciferol and calcium increase the absorption of tetracyclines from the gastrointestinal tract. That is why the period between taking Natekal D3 and tetracyclines should be at least three hours.
The simultaneous use of Natekal D3 reduces the absorption of bisphosphonates and sodium fluoride. GCS reduce calcium absorption.
The simultaneous use of diuretics from the thiazide group increases the likelihood of hypercalcemia due to increased reverse absorption of calcium from the lumen of the renal tubules. "Furosemide" and other "loop" diuretics enhance the excretion of calcium by the kidneys.
Concomitant use with laxatives and colestyramine reduces the absorption of cholecalciferol. The slightly alkaline reaction of food products decreases, and the acid reaction increases calcium absorption.
Recommendations
During drug therapy, constant monitoring of the excretion of calcium with urine and the concentration of creatinine and calcium in the blood plasma is required. The dosage should be reduced or therapy should be temporarily stopped if the concentration of creatinine or calcium in the blood serum has increased, the degree of calcium in the urine is above 7.8 mmol per day (300 milligrams in 24 hours).
When using the medicine, the additional intake of D3 from other sources must also be considered. The simultaneous use of multivitamin complexes that contain vitamins of group D and calcium is prohibited.
To prevent a decrease in absorption of sodium fluoride or bisphosphonate, it is advisable to take "Necal D3" at least three hours after their use.
Due to corticosteroids, calcium absorption is reduced, therefore, against the background of hormone treatment, an increase in the dosage of the drug may be necessary. In elderly patients, the need for calcium is one and a half grams per day, and in vitamin D3 - 1000 IU. So it says in the instructions.
Price "Natekalya D3" and analogues
The drug is sold in pharmacies, a prescription is not required. The cost of chewable tablets is approximately 465 rubles. Absorbable pills are slightly cheaper - about 435 rubles per pack.
Analogues of the drug in domestic pharmacies are as follows: Bonocal, Carbocal D, Calceos, Calcium-D3, Nicomed Osteoforte, Beresh Calcium Plus D3, Ostalon Calcium-D.
Reviews about "Necale D3"
Many patients who are deficient in calcium in the body want to know the opinion of specialists about Natekal D3. Doctors positively describe this drug and often prescribe it to patients who suffer from osteoporosis and other diseases caused by a lack of calcium and cholecalciferol. The drug helps restore calcium-phosphorus balance in the body, strengthen teeth, nails and bones. The medicine has earned positive reviews from doctors due to the fact that it is well tolerated by patients, and it very rarely causes unwanted effects.
We reviewed the preparation "Natekal D3" instructions for use, price and reviews.