In the article, we consider the instructions for use, price, reviews and analogues of the Omeprazole preparation.
It is an effective and modern drug, which is prescribed for the treatment of erosive disorders of the stomach, gastritis and ulcers due to high acidity. The active ingredient has an anti-inflammatory effect. The properties of the drug are activated when it enters an aggressive gastric environment.
Structure
According to the instructions for use with Omeprazole, the active component of the drug is omeprazole. The drug is presented in pharmacies in several ways:
- Enteric-coated capsules of 10 or 20 mg of active substance. Packaged in blisters for seven pieces, up to four in one package.
- Coated tablets of 10, 20 or 40 mg of the active ingredient. Packed in packages of 7, 14 and 28 pieces.
- Powder intended for the preparation of a solution for injection injection of 40 mg of active substance in one bottle.
The properties
The medication can reduce the aggressiveness of the gastric environment by reducing the production of hydrochloric acid. The active component comes into an active state only after reaching the biological environment of the stomach.
The instructions for use with Omeprazole tablets indicate that regardless of the nature of the stimulus, the drug reduces the stimulated and basal secretion species. When taking 20 mg of omeprazole during the first hour, the antisecretory property of the drug is activated. For a day after taking the drug, secretion is inhibited by half. Even a single dose can significantly reduce the night and day secretion of the stomach. The peak effectiveness of Omeprazole occurs on the fourth day of admission. The effect continues to last for several days after the end of the drug.
Indications
In accordance with the instructions for use, Omeprazole is prescribed for the prevention and treatment of various pathological processes in the digestive system. It is produced by various pharmaceutical companies, including Akrikhin. It is this manufacturer that produces the most common version of the drug called "Omeprazole-Akrikhin." According to the instructions for use, the indications for all variants of the drug are identical, namely:
- Zollinger-Ellison disease.
- In combination with other drugs in the treatment of polyendocrine adenomatosis.
- Treatment of erosive esophagitis confirmed by the endoscopic method.
- Prevention of uncomplicated heartburn, the duration of which is more than two days a week.
- Gastropathies arising from the use of non-steroidal anti-inflammatory drugs.
- Elimination of symptoms of gastroesophageal reflux when the contents of the stomach are thrown into the lower part of the esophagus.
- Treatment of peptic ulcer in the active stage, which arose as a result of infection of the body Helicobacter pylori.
- Prevention of a duodenal ulcer, which is in a chronic form of the course, as well as stress and aspirin ulcer pathology.
- Correction of secretion disorders in the upper digestive system.
In the instructions for use with Omeprazole, the price is not indicated.
Contraindications
Caution should be taken when taking patients with kidney and liver failure. Absolute contraindications to taking the drug are the period of gestation and breastfeeding, hypersensitivity to the components and children's age.
Instructions for use
"Omeprazole" in capsules is taken according to the instructions in the morning. Capsules cannot be chewed; they are swallowed whole and washed down with a small amount of water. The instruction provides the following dosages:
- Prevention of ulcerative pathology: 10 mg for a single dose per day.
- Zollinger-Ellison pathology: 60 mg for a single dose per day. It is possible to increase the daily dosage to 80-120 mg, while the drug is taken in the morning and evening.
- An ulcer, gastropathy, and reflux esophagitis in an acute form during treatment with non-steroidal anti-inflammatory drugs suggest a daily dosage of 20 mg. If the course of reflux esophagitis is characterized as severe, the dosage can be doubled.
As for the duration of the course of treatment, with peptic ulcer it ranges from two weeks to one month. If an ulcer, reflux esophagitis and various disorders in the functioning of the gastrointestinal tract were triggered by NSAIDs, then Omeprazole tablets according to the instructions for use should be taken for up to two months.
When is the effect?
In most cases, the severity of the symptoms of the disease decreases after two weeks of regular use of the drug. If scarring of the ulcer has not completed after a two-week course, treatment should be continued for another 14 days. If the patient's body shows resistance to other antiulcer drugs, the daily dosage of Omeprazole should be 40 mg. A duodenal ulcer involves taking the drug for one month, esophagitis and a gastric ulcer will require an increase in this period to two months.
Two treatment regimens
As indicated by the instructions for use with Omeprazole, two standard treatment regimens are used to eliminate Helicobacter pylori from the body of bacteria:
- The combination of omeprazole, amoxicillin and clarithromycin in a ratio of 20/1000/500 mg. Medications are taken in the morning and evening. It is also possible to replace amoxicillin with 400 mg of metronidazole while reducing the dosage of clarithromycin to 250 mg. Another therapeutic regimen: omeprazole, amoxicillin and metronidazole in a ratio of 40/500/400 mg for three times a day. Treatment lasts one week.
- Treatment options of two drugs are also provided: omeprazole and amoxicillin in doses of 20/750 mg in the morning and evening; omeprazole and clarithromycin 40/500 mg for three times a day or 750-1500 mg of amoxicillin twice. In this embodiment, the treatment involves taking the drugs for two weeks.
If the patient has a history of liver failure, 10-20 mg is prescribed once a day. In old age, a change in treatment regimen is not required. So it is said in the instructions for use with Omeprazole. The price of the drug is quite reasonable.
Adverse reactions
In most cases, omeprazole is well tolerated by patients. The optimal course of treatment is taking the drug for a maximum of a month. A second course can be taken only after a break. With self-medication or incorrect therapy, the development of the following undesirable consequences is possible:
- The development of arthralgia, myasthenia gravis, myalgia and other disorders in the musculoskeletal system.
- From the hematopoietic system, the occurrence of agranulocytosis, leukopenia, pancytopenia and thrombocytopenia is possible.
- An allergic reaction is manifested by urticaria, fever, angioedema and anaphylactic shock, as well as bronchospasm.
- A rash and itching, sensitivity to sunlight, alopecia, etc. may appear on the skin.
- The digestive system can respond to omeprazole with soreness in the abdomen, nausea and vomiting, digestive disorders, flatulence, constipation and diarrhea.
- Disorders in the nervous system are characterized by dizziness, pain in the head, a state of agitation and depression. In some cases, the development of encephalopathy is possible.
- Other adverse reactions: swelling of the extremities, impaired visual function, general malaise, gynecomastia, sweating.
This is confirmed by the instructions for use with Omeprazole. Price, reviews and analogues will be discussed below.
With a significant excess of the prescribed dosages and duration of administration, the development of such symptoms of an overdose as drowsiness, nausea and headache is possible. In rare cases, impaired vision and consciousness, as well as tachycardia, have been reported.
If you find these symptoms, you need to get qualified medical help. The treatment is symptomatic, since there is no specific antidote. This is indicated in the instructions for use. The price and reviews of Omeprazole are of interest to many.
Analogs
This medication is very popular and effective, which explains the appearance of numerous analogues based on the identical active component. The cost of drugs varies significantly depending on the manufacturer. If necessary, replace one drug with another, you should consult a specialist, since the composition of the auxiliary components, and hence contraindications, may differ.
We will not consider in detail instructions for use with Omeprazole analogues.
The most common and popular substitutes with the same active component in the composition are:
- Omezol.
- "Gastrozole".
- Omefez.
- "Bioprazole".
- Omeprazole-Akrikhin.
- "Losek."
- Omez.
The latter is most often prescribed as an analogue of Omeprazole. The main difference between the two drugs is the high cost of Omez.
We reviewed the instructions for use with Omeprazole.
Reviews
Reviews confirm its high degree of effectiveness. He copes well with the aggravated form of peptic ulcer and other disorders of the gastrointestinal tract.
Experts also invariably respond well to the drug, emphasizing its affordability in terms of cost (the price per package starts from 27 rubles), combined with high efficiency. "Omeprazole" is often used to eliminate heartburn and can be used for a long time only if necessary, without switching to regular intake. Reviews about Omeprazole from different manufacturers do not differ from each other, so we can conclude that there is no difference between them.
Negative reviews mainly relate to the treatment of severe peptic ulcer. In some cases, taking "Omeprazole" did not give the expected therapeutic effect, but only reduced the intensity of the manifestation of symptoms of pathology.
Conclusion
In order for any drug to be beneficial, one should listen and strictly follow the instructions of the attending physician. Self-administration of Omeprazole can lead to negative and unpleasant consequences. Only in case of taking the correct dosages and observing the duration of the course of treatment can the expected effect of therapy be obtained.
The article was presented to the drug "Omeprazole" instructions for use, price and reviews.