In case of muscle spasm of smooth muscles and pain, doctors prescribe "Platifillin" with anticholinergic, sedative and antispasmodic effect. Self-medication is contraindicated, before starting the course, you need to consult a doctor about the use of Platifillin. The form of the drug is a solution for parenteral administration and tablets for oral use.
"Platifillin" is a therapeutic drug from the group of anticholinergics, which has an antispasmodic and mild sedative effect.
Structure
"Platifillin" is a colorless, clear, odorless solution. This medicine is produced in ampoules, there are ten in total in a package. In addition, an ampoule knife can go.
In one ampoule, one milliliter of 0.2% of the drug. The active substance is platifillin. In addition, "Platifillin" is available in tablets.
Pharmacological actions
According to the instructions for use, Platifillin injections are considered a cholinergic blocker and have a pronounced antispasmodic effect on the smooth muscles of the digestive organs and bronchi, and also have a sedative effect.
This medication lowers the production of bronchial, salivary, lacrimal and sweat glands. In addition, the medicine is able to dilate the pupil and provoke moderate accommodation paralysis. "Platifillin" may increase intraocular pressure.
When can I use the drug?
The following conditions and diseases serve as indications for Platifillin in injections:
- Hepatic colic (the most common clinical manifestation of gallstone disease, an acute attack of visceral pain, the cause of which is blockage of the calculus of the cystic duct).
- Intestinal dyskinesia (a functional intestinal lesion that occurs with pain, discomfort in the abdominal cavity).
- Violation of the motility of the biliary tract.
- A chronic disease that occurs with the formation of ulcers in the stomach, as well as a tendency to progression.
- An acute attack of pain in the lower back, which is caused by a sharp violation of the outflow of urine from the kidney and a violation of microcirculation in it.
- Bronchospasm (a pathology that occurs when the smooth muscles of the bronchi are reduced and their lumen is reduced).
What contraindications does the drug have?
According to the instructions for use with Platifillin injections, it is known that this drug has a huge list of prohibitions on use, therefore administration without a medical specialist is contraindicated.
"Platifillin" is prohibited for use in the following conditions:
- Hypersensitivity to platyphyllin.
- Chronic eye disease, which is characterized and manifested by bouts of increased intraocular pressure.
- Severe atherosclerosis (a chronic disease of the arteries that occurs due to impaired lipid metabolism and is accompanied by deposition of cholesterol in the inner lining of the vessels)
- Tachycardia (increase in heart rate from 100 beats per minute).
- Benign prostatic hyperplasia (a benign tumor originating from the glandular epithelium).
- Diseases of the esophagus and ligamentous apparatus of the diaphragm, in which there is an expansion of the esophageal opening of the diaphragm and ligaments are fixed, fixing the esophagus and stomach.
- Atony of the intestine (a condition associated with a decrease in muscle peristalsis).
- Gastroenterorrhagia (gastrointestinal bleeding).
- Ulcerative colitis (a chronic inflammatory disease of the colon mucosa).
Additional Prohibitions
It is necessary to carefully weigh the benefits and risks of using Platifillin during the following conditions and ailments:
- The "interesting position" of women and lactation.
- Cardiac ischemia (damage to the heart muscle that is triggered by the cessation of myocardial microcirculation).
- Arterial hypertension (an increase in blood pressure from one hundred and forty to ninety millimeters of mercury and higher).
- Thyrotoxicosis (a pathology in which excessive thyroid hormone formation occurs in the body).
- A chronic disease characterized by the absence or insufficient reflex relaxation of the lower esophageal sphincter, resulting in an intermittent violation of the patency of the esophagus.
Also, with extreme caution, it is necessary to apply this medication to patients with the following diseases:
- Nonspecific ulcerative colitis (chronic bowel disease, which is accompanied by pain in the abdomen, stool disorders).
- Myasthenia (neuromuscular disease, which is characterized by pathologically sharp fatigability of striated muscles).
- A history of urine retention.
- Cerebral palsy (a term that unites a group of chronic non-progressive symptom complexes of motor disorders secondary to brain lesions or abnormalities that occur in the perinatal period).
How to use the drug?
According to the instructions for use, the drug can be administered both subcutaneously and intramuscularly. To eliminate acute abdominal pain that is provoked by hepatic or renal colic, as well as with an ulcer, it is necessary to administer “Platifillin” subcutaneously in a dosage of one to two milliliters from two to three times a day.
The duration of the course of therapy can be up to ten days. The maximum daily dosage for an adult patient can be up to thirty milligrams (fifteen milliliters of the drug), a single dose should not be higher than ten milligrams (five milliliters).
How to take "Platifillin" for children?
For patients under eighteen years of age, the drug is used in the following concentrations:
- For babies up to one year - a single dosage will be 0.035 milligrams per kilogram, the maximum daily content of the active substance is 0.07 milligrams per kilogram of weight.
- Children from one year and a half years old - a single concentration of the active component will be 0.03 milligrams per kilogram, the maximum daily dosage is 0.06 mg / kg.
- Children from six to ten years of age - a single dosage will be 0.025 milligrams per kilogram, the maximum daily content of the drug is 0.05 mg / kg.
- Adolescents from eleven to fourteen years old - 0.02 milligrams per kilogram of weight, the maximum daily dosage for this age will be 0.04 mg / kg.
According to reviews, tablets "Platifillin with papaverine" can be taken up to three times a day.
Adverse reactions
According to the instructions for use, "Platifillin" can provoke the following negative phenomena:
- Dry mouth.
- Lowering blood pressure.
- Tachycardia (heart palpitations).
- Dizziness (characterized by the feeling that the surrounding objects and the person himself begins to spontaneously move in space).
- Migraine (a disease in which the most frequent and characteristic symptom is persistent severe pain).
- Tremor (fast, rhythmic movements of the limbs or trunk, caused by muscle contractions and associated with a time delay of correcting afferent signals).
- Urine delay.
- Pupil enlargement.
According to reviews, the drug rarely provokes side effects in young adults, as a rule, negative reactions can occur in patients of retirement age with severe somatic pathologies.
Overdose
With drug poisoning, the following diseases can occur:
- Ishuria (a pathological condition associated with the inability to independently empty the urinary bladder from urine when it is full).
- Paralysis of accommodation (a rare pathology when the near and far points of a clear vision merge together).
- Dysphagia (a violation of swallowing caused by a neurogenic and physiological nature).
- Mydriasis (dilated pupil).
- Tremor (fast, rhythmic movements of the limbs or trunk, caused by muscle contractions and associated with a time delay of correcting afferent signals).
- Fever.
- Neurasthenia (a mental disorder from the group of neurosises, manifested in increased irritability, fatigue, loss of ability to prolong mental and physical stress).
- The elimination of poisoning is reduced to the use of forced diuresis, the introduction of cholinostimulants and anticholinesterase medications. With an increase in body temperature, it is necessary to take antipyretic drugs.
When excited, a person is recommended to administer an intravenous solution of sodium thiopental. With the expansion of the pupil, it is necessary to instill eye drops of "Pilocarpine" or "Phosphacol."
Does Platifillin interact with other drugs?
It is known that the use of the drug with magnesium sulfate and ethanol chloride enhances their sedative effect. The combined use of haloperidol, phenothiazine, monoamine oxidase inhibitors, tricyclic sedatives and some antihistamines increases the likelihood of side effects. Anticholinesterase drugs are considered antagonists of "Platifillin."
It is known that morphine together with this medicine increases the inhibitory effect on the heart and blood vessels. Painkillers and sedatives, along with Platifillin, increase its antispasmodic effect. With vascular spasms, it is good to use the drug simultaneously with antihypertensive and sedative drugs.
During therapy "Platifillinom", according to patients, it is important to refrain from driving a car and performing work that requires concentration. What analogs does Platifillin have?
"Papaverine"
The drug is a medicine from the group of antispasmodics, which is used in many areas of medicine to lower the tone of smooth muscles.
Papaverine or Platifillin, which is better? The second drug has a more pronounced analgesic effect. With the help of its vasodilating effect, the medication can slightly affect blood pressure.
In people with increased tone of the gallbladder, the stimulation of nerve impulses is moderately reduced. And also the drug relaxes the smooth muscles of the uterus, bladder and urinary tract.
Papaverine is an analogue of Platifillin in ampoules. They are also produced in combination, in one drug. This is a combined medication. The drug has an antispasmodic effect, provokes the expansion of small capillaries of the skin. It reduces the tone of smooth muscles, as well as the amplitude and frequency of peristaltic contractions of the stomach, duodenum, small and large intestines.
No-shpa
Tablets are a representative of the therapeutic group of antispasmodics. They lower the tone of the smooth muscles of the walls of the hollow organs and are used for various pathologies that are accompanied by spasms. "No-shpa" and "Platifillin" are antispasmodic drugs that eliminate unpleasant symptoms.
After using the drug, the orally active substance is rapidly and completely absorbed from the intestinal lumen into the general bloodstream. It spreads uniformly throughout all body tissues and enters the smooth muscle cells.
Generics
The following medicines are analogues of "Platifillin":
- "Altaleks".
- Andipal.
- "Dibazole".
- "Dicetel".
- "Droverin."
- Drotaverinum.
- Kellin.
- Librax.
- Niaspam.
- "No-shpa."
- "Nominated."
- "Papaverine".
- "Plantex".
- "Platifillin with papaverine."
- Spazmol.
- Sparex.
- "Trigan."
- "Cystenal."
- Unispaz.
Before replacing Platifillin with an analogue, you should consult a medical specialist and make sure that there are no contraindications for taking a generic.
Opinions
Reviews of "Platyphylline" narrate about the effectiveness of the drug, but use requires great care. The pharmacological action of "Platifillin" is aimed at smooth muscles, the tension and relaxation of which a person cannot control - just feel the result of her lack of normal tonus of skeletal muscles and internal organs or an increase in tonus. Supervision by a competent medical specialist who can regulate the whole process is necessary.