Treatment of depressive processes is not complete without the use of antidepressants, which include the medication "Clofranil." The instruction recommends using it to eliminate various phobias, pain syndromes.
Drug description
The active component of the drug is clomipramine hydrochloride. It is produced by the Indian company San Pharmaceutical Industries in the form of blue round coated tablets.
The dosage of the drug is 0.025 g of clomipramine hydrochloride.
Mechanism of action
The medicine "Clofranil" instructions for use relates to antidepressant drugs with a tricyclic structure. With his participation, thymoanaleptic activity is carried out with a psychostimulating, anxiolytic, alpha-adrenergic and sedative effect. The latter property is possible due to the affinity with H 1 -histamine receptors.
It differs in analgesic, histamine-blocking and antiserotonin effects. Eliminates spontaneous urine output at night, suppresses the desire to eat.
It exhibits an anticholinergic effect of a peripheral and central nature caused by a strong attachment to cholin-dependent receptor formations.
The drug "Clofranil" refers to antiarrhythmic drugs such as quinidine, blocking sodium channels. Therapeutic doses of clomipramine inhibit conduction in the ventricles of the heart.
Antidepressant activity occurs due to an increase in the noradrenaline level at the sites of neuron contact and serotonin content in the nervous system. These neurotransmitters accumulate due to the fact that membranes of presynaptic neurons weaken re-capture.
Long-term use causes a decrease in functional activity in the receptor formations of the serotonin type and beta-adreno-dependent, located in the brain, helps normalize adrenergic and serotonergic transfer, and restores balance in systems that were upset by depressive manifestations. Clofranil tablets help to cope with the inhibition of the psychomotor type, depressed mood, anxious feeling.
Analgesic activity manifests itself with a change in the monoamine level in the departments of the central nervous system.
An anxiolytic effect occurs with reduced excitation of the nucleus in the brain stem of the brain, which is regulated by the function of beta and alpha2-adrenergic receptors , as well as by the noradrenaline circuit.
Antidepressant activity is observed already 7 days after the start of treatment.
In clomipramine, compared with imipramine, the psychostimulating effect is reduced, and when compared with amitriptyline, its sedative activity will be less pronounced.
Why take
The medication "Clofranil" instructions for use recommends that you use depressants of different development for well-being, differing in certain symptoms.
The medicine is prescribed for a depressive syndrome that accompanies schizophrenic manifestations, prolonged pain, bodily diseases and personality discrepancies. They are treated with presenile and senile type processes, as well as their manifestations in childhood.
“Clofranil” medication instructions for use, the photo of which is presented below, indicates the use in case of a compulsive-obsessive disease associated with phobias, with fears of panic, periodic pain during oncology, migraine, rheumatic disease.
It helps with postherpetic damage to nerves in the periphery, post-traumatic and peripheral neuropathy, narcolepsy, catalepsy. The drug is taken to prevent headaches and migraine attacks.
How to use
In the form of tablets, the “Clofranil” drug is recommended for use when eating food or after a meal to reduce irritation to the mucous membranes of the gastric wall.
For therapy, a small dosage is used, these rules apply to people in the elderly and adolescence.
Depression, an obsessive-compulsive disease and various phobias are treated with a dosage of 0.025 g in 3 doses per day. In the first week, the daily dose increases, per day, you can take from 0.100 to 0.150 g. If necessary, apply even larger doses. When there is an improvement, they switch to maintenance therapy, which ranges from 0.050 to 0.100 g of the drug.
Narcolepsy with catalepsy attacks is eliminated with tablets with a daily dose of 0.025 to 0.075 g of clomipramine. Chronic pain is treated with a daily dosage of from 0.100 to 0.150 g, which is combined with concomitant analgesics, the amount of the latter can be gradually reduced.
To eliminate bouts of fear, initially use per day 0.010 g of the drug, which can be combined with benzodiazepine. If the medicine is well tolerated, then its amount is increased until positive changes appear. Then a gradual withdrawal of benzodiazepine drugs is carried out. Treatment with the drug "Clofranil" instruction advises to cancel only six months later and not before. Over a given period of time, it is necessary to gradually reduce the maintenance dosage.
In senile age, therapy is prescribed with a daily dosage of 0.010 g. Then, over 10 days, the amount of medication is increased to an optimal level, which is from 0.030 to 0.050 g. This dose is used throughout the therapy.
Undesirable consequences
Like all antidepressants, Clofranil may cause side effects. The anticholinergic effect is manifested by a fuzzy visual process, accommodative paresis, dilated pupils, increased pressure inside the eye, increased heart contractions, dry oral cavity, mental confusion, delirium, constipation, paralytic intestinal conduction, difficulty urinating, and little sweat.
Changes in the nervous system are characterized by a drowsy, asthenic process that causes disorientation, anxiety, agitation, motor anxiety, manic or hypomanic changes. Side effects are also characterized by aggression, memory failures, depersonalization, poor attention, insomnia, nightmares, asthenia.
Undesirable reactions of the heart and blood vessels are manifested by sinus rises or changes in heart rhythm, collapse of the orthostatic appearance, malfunction of conduction inside the ventricles, and pressure inconsistency.
Means “Klofranil” instructions for use describe changes in the digestive system, which are expressed by a nauseous state, icteric hepatitis, heartburn, pain in the stomach, increased or decreased desire to eat, stomatitis, dental problems, changes in taste preferences, blackening of the surface of the tongue.
Hormonal disorders are characterized by testicular edema, overgrowth of the mammary glands in the male and an increase in women, an excessive dose of prolactin, galactorrhea, low or high sex drive, impaired potency, hyper- or hypoglycemia, hyponatremia, inadequate secretion of the antidiuretic hormone.
A change in the work of the hematopoietic organs is associated with a decrease in the number of leukocyte and platelet blood cells, purpura, and an increase in the number of eosinophils.
An allergic reaction may occur in the form of a skin rash with itching, fear of ultraviolet radiation, angioedema edema.
Side effects are associated with a decrease in scalp, petechiae, a sensation of a warm or cold state, delayed or rapid urination, with a decrease in the concentration of proteins in the blood, with febrile syndrome and high fever.
As a result of the sudden withdrawal of the medication, nausea, vomiting, digestive upset, headache, malaise, insomnia, and dreams may occur. A gradual decrease in the dose of the drug can make a person irritable, cause a state of motor anxiety.
For children
An obsessive-compulsive syndrome is treated with an initial dosage of 0.0125 g. A gradual increase in concentration is carried out over 14 days, taking into account the tolerance of the drug. The daily dose after 2 weeks is equal to 0.100 g or it is calculated by the weight of the child, when for every 1 kg of weight there is 0.003 g of active substance. The next 14 days are accompanied by a gradual increase in the concentration of the drug to 0.200 g or recalculation by weight.
Prescribing Clofranil for children reviews deserves a positive character in the treatment of nocturnal enuresis. Initial therapy is carried out in a daily dose in the amount of 0.020-0.030 g for ages 5 to 8 years old, for adolescents from 9 to 12 years old use 0.025-0.050 g; after 12 years, 0.025-0.075 g is prescribed.
Increasing the dosage is carried out for patients who did not help the medicine at all 7 days after therapy. The entire daily dose of the drug is prescribed to drink for one use in the evening after a meal. With involuntary urination in the evening during sleep, half the dosage is prescribed to drink up to 17 hours. When the desired effect is achieved, the drug is not abandoned for about 90 days, during which a gradual decrease in the level of the drug is carried out.
The medicine "Clofranil" analogues
There are many medications based on clomipramine hydrochloride that are considered interchangeable.
One such remedy is the Italian medicine Anafranil, which is produced by Novartis Pharma. It is also referred to tricyclic antidepressants . With this psychotropic agent, depressive processes and mental disorders are treated. Clofranil and Anafranil preparations contain the active ingredient clomipramine in the form of a hydrochloride salt.
A medication is available in the form of tablets with a regular and sustained release. Its simple dosage is 0.025 g, and the retard includes 0.075 g of the active component. Conventional tablets have a light yellow sugar coating. A prolonged form of the drug contains a pink coating.
There is a liquid type of medicine, which is represented by a solution for the introduction of extra-muscular and intravenous 2 ml. The dosage of the injection drug Anafranil is 0.025 g of clomipramine hydrochloride, which is dissolved in sterile water and glycerin.
Another similar remedy is the drug Clomipramine, which is available in the form of tablets for oral use. To protect the mucous membrane of the digestive system, they are coated. The dosage is 0.025 g of clomipramine hydrochloride. To indicate it, “25” is stamped on each tablet. The action of the drug is aimed at combating the depressive state. The drug is dominated by psychostimulating, timoleptic and sedative activity. The latter function is associated with blocking the reverse neuronal uptake of serotonin molecules, which improve the patient's mood.
It is used to treat depressive processes that are caused by various causes. The drug treats psychopathy, schizophrenia, phobias, panic disorders of an obsessive-compulsive nature, cataplexy, narcolepsy well. Children after 5 years of age are prescribed to eliminate nighttime incontinence.
In the medicine "Clofranil" analogues may contain an active substance other than clomipramine hydrochloride. For example, the Soneks preparation contains the active component zopiclone, which is contained in a single dose of 0.0075 g. The medication causes the onset of sleep, has a calming, anticonvulsant and muscle relaxant effect. The general quality of Clofranil and Sonex is their sedative property.
It is produced by the Belarusian pharmaceutical company LLC Rubicon in the form of round, biconvex tablets with a white shell coating and is at risk for halving. It is used to treat severe sleep disorders, with situational and temporary insomnia.
The medicine "Truxal"
It is considered another similar analog based on chlorprotixen hydrochloride, which is a thioxanthene derivative. It is produced by the Danish company JSC Lundbeck. The drug refers to antipsychotics that have antipsychotic, pronounced sedative and moderate antidepressant activity.
There are four dosages of the drug: 0.005, 0.015, 0.025 and 0.050 grams. The first three doses are available in the form of brown tablet units of biconvex and round shell coating. The highest dose is represented by an oval tablet with biconvex surfaces.
Antipsychotic activity is due to inhibition of dopamine receptor formations. With the blockade of these areas, an antiemetic and analgesic effect of the drug occurs. The drug inhibits 5-HT2 receptor associations, α1-adrenergic and H1-histamine-dependent receptors, which causes adrenergic blocking, anti-histamine activity.
The drug is considered a neuroleptic drug with a calming effect, which is intended for the treatment of psychotic, schizophrenic and crazy attacks.
It is used to eliminate childhood deviations in behavior, to overcome a hangover withdrawal syndrome with alcohol and drug addiction, to combat hyperactivity, an irritable process, confused consciousness in old age.
The drug is effective in depressive changes, sleepless, neurosis.
Together with the analgesic medication, the drug Truxal eliminates painful processes.
Comparison of Clofranil with analogues
The closest in action and composition is the medicine "Anafranil" in the form of tablets with a usual release. Dosage forms of a retard with a dosage of 0.075 grams and a solution for intramuscular and intravenous use cannot be compared with the Indian antidepressant, since it is not available in this form.
Many patients are tormented by the question: how is Clofranil different from Anafranil? First of all, there is a difference in the composition of inactive ingredients. The presence in the Indian preparation of brilliant blue, sodium carboxymethyl starch, hypromellose 2910, macrogol 6000, which are not found in the Italian medication, indicates the difference between the two analogues. These ingredients in the Anafranil tablets are replaced by stearic acid, 85% glycerol, hydroxypropyl methylcellulose, vinylpyrrolidone-vinyl acetate copolymer, crystalline sucrose, K30 polyvinylpyrrolidone, 5% yellow oxide, titanium dioxide, 8,000 macrogol.
The presence of milk sugar in both preparations enhances the bioavailability of the active substance. However, the presence of lactose makes them unsuitable for people with intolerance to this component.
Different auxiliary ingredients of the two analogues alter the strength of penetration, absorption, exposure and excretion of clomipramine hydrochloride from the body. They are also responsible for the development of all kinds of side effects.
The difference between Anafranil and Clofranil is related to the price. An Italian preparation costs a little more than an Indian counterpart.
If you compare which is stronger: “Truxal” or “Klofranil”, then it is believed that the first medication has a stronger sedative, calming and inhibitory effect, which allows you to overcome various psychotic disorders.
According to the mechanism of influence of antipsychotics are very different from antidepressant drugs. The action of the drug "Truksan" is aimed at suppressing pathological mental activity, at reducing the work of neurotransmitter substances. With the help of the medication “Clofranil,” their function is enhanced and stimulated.
The release of dopamine is suppressed by antipsychotics, and exposure to antidepressants enhances the production of this substance.
Patient opinions
About the medicine "Clofranil" reviews can be heard various. Many patients who are in a state of depression, this tool helped to get rid of negative and obsessive thoughts, there was joy in life.
For other people, the drug was prescribed for alcoholism with severe psychological dependence. After the course of taking the medicine, the patient came to an adequate, calm, balanced state, aggression goes away.
On the drug "Clofranil" instructions for use reviews contain both positive and negative.This is due to the fact that the section "Adverse Reactions" contains a huge list of undesirable consequences that may occur during treatment. In practice, many doctors note the good tolerance of this drug, the main thing is to choose the right dose and adjust it in time if necessary.
Positive reviews for the drug “Clofranil” are associated with the manifestation of its effectiveness in a timely manner, which are declared by the manufacturer of the drug. Also pleased with its affordability. The medication begins to act one week after the start of use, which is very important for relieving an acute attack of the disease.
The disadvantage is that drug treatment cannot be immediately canceled, but a gradual reduction in dosage is required.
Patients with panic disorder in the initial stages of therapy experience increased anxiety. This paradoxical feature manifests itself during the first day, and then decreases after two weeks.