What are magnesium supplements for? This element is very important for the human body. With its shortage, not only the heart and blood vessels suffer, but also other systems and organs.
The most popular magnesium-containing drug is Magvit. Analogues of this tool, its cost and instructions are presented below.
Form of medication, description, packaging, composition
In what form are the drug in question made? What does the instructions for use say about this? Magvit is a No. 0 gelatin hard capsule. They are yellow in color and contain white powder.
The main substances of this tool are magnesium citrate and pyridoxine hydrochloride. Also mentioned medicine includes potato starch, lactose and magnesium stearate.
The gelatin shell contains pharmaceutical gelatin, glycerol, methyl parahydroxybenzoate, purified water, propyl parahydroxybenzoate, titanium dioxide, sodium lauryl sulfate and dyes.
Magvit capsules are available, the price of which is indicated below, in cell contour packs and cardboard boxes.
Act
How does the medication in question work? What information does the instructions for use contain? "Magvit" has high efficiency, which is due to the properties of pyridoxine hydrochloride and magnesium.
As you know, magnesium takes part in the utilization, storage and transfer of energy, as well as the synthesis of nucleic acids and protein. This element controls and normalizes the balance of intracellular potassium, is a cofactor of mitochondrial processes and enzymatic reactions.
Magnesium preparations are especially important for the brain. The mentioned element is an obligatory participant in the synthesis of all neuropeptides, RNA transcription and DNA replication.
A lack of magnesium in the human body is manifested by tremors, muscle weakness, ataxia, tetany, irritability, increased reflex irritability, heart rhythm disturbances, sleep disorders and diarrhea.
As for pyridoxine hydrochloride, this substance is involved in the synthesis of neurotransmitters and protein metabolism, and also improves fat metabolism in atherosclerosis. After entering the body, it is phosphorylated and converted to pyridoxal-five-phosphate. This component also transaminates and decarboxylates amino acids and transports them across cell membranes.
Pyridoxine hydrochloride is involved in the metabolism of glutamic acid, tryptophan, methionine and cysteine. It is necessary for the activation of phosphorylase and the formation of gamma-aminobutyric acid, neurotransmitters, serotonin and glycine. This element promotes the exchange of vitamin B12 and folic acid. He takes part in the exchange of fatty unsaturated acids and the synthesis of porphyrins.
Basic properties
What properties does the medicine “Magvit” have? Acceptance of this combination drug is justified by the following reasons:
- Vitamin B6 helps increase the concentration of magnesium in red blood cells and plasma, as well as reduce its output from the body;
- magnesium and vitamin B6 complement each other's effects;
- magnesium activates the processes of transformation of pyridoxine into its derivative component (pyridoxal-five-phosphate) in the liver;
- Vitamin B6 improves the absorption of magnesium from the intestine and its penetration into cells;
- Vitamin B6 enhances and strengthens intracellular magnesium.
Kinetics
How and where does the absorption of the drug in question occur? What does the instructions for use say about this? "Magvit" is absorbed from the digestive tract. Its absorption is 50% of the dose taken.
In the human body, magnesium is distributed in the intracellular space, and is excreted through the renal system.
Pyridoxine hydrochloride is absorbed from the small intestine. Together with the flow of blood, it spreads through the tissues and penetrates into the cells. There, vitamin B6 is phosphorylated by pyridoxalkinases and ATP.
Coenzyme decomposition occurs by oxidation and dephosphorylation in tissues. Its catabolism product is four-pyridoxyl acid. From the body, it is excreted with urine.
Indications
In what cases should the drug "Magvit" be used? Reviews claim that this remedy is prescribed only with established magnesium deficiency, isolated or associated with other human conditions.
Contraindications
The drug "Magvit" (B6 + magnesium) can not be taken with hypersensitivity to its ingredients, severe renal failure, in childhood and with phenylketonuria.
With caution, this tool is recommended for use with moderate renal failure. This is due to the fact that there is a high risk of developing hypermagnesemia.
Instructions for use
"Magvit" should be taken only after consulting a doctor. For adults, it is prescribed inside two capsules three times a day. The duration of treatment with this agent is 30-60 days.
The considered capsules are taken only during a meal, washed down with plain water. After the concentration of magnesium in the blood is normalized, therapy should be discontinued.
Overdose cases
When using large doses of the drug, the following symptoms occur: a sharp drop in blood pressure, vomiting, respiratory depression, nausea, slowing reflexes, cardiac arrest, coma, anuria and heart paralysis.
For the treatment of such conditions, rehydration and forced diuresis are performed.
In the presence of renal failure, peritoneal dialysis or hemodialysis is required.
Side effects
The drug in question can cause allergic reactions. Digestive tract disorders (e.g. diarrhea, nausea, abdominal pain, vomiting, constipation, or flatulence) are also possible.
Interaction with other medicines
When prescribing the drug "Magvit", you should definitely inform your doctor about the use of other drugs, as they may be incompatible.
The parallel use of tablets containing calcium salts or phosphates can significantly reduce the absorption of magnesium from the digestive tract.
Magnesium-containing agents reduce the absorption of tetracycline. Therefore, before using Magvit capsules, it is imperative to observe an interval of 3 hours.
Magnesium is able to reduce the absorption of iron, as well as weaken the effect of thrombolytic agents for oral administration.
During pregnancy and breastfeeding
During pregnancy, this medication can be used only on the recommendation of a doctor (strictly according to indications).
According to expert reviews, magnesium penetrates into breast milk quite well. Therefore, the use of the drug in question during breastfeeding should be avoided.
Recommendations to patients
With a concomitant deficiency of calcium, a lack of magnesium in the human body should be eliminated before the introduction of Ca preparations.
With the regular use of laxatives, alcohol, and also with increased mental and physical stress, the need for magnesium in the patient increases. This can lead to the development of its lack in the body.
Terms and conditions of storage
The shelf life of this product is two years. The drug must not be used after the period indicated on the package.
The medication in question is stored only in a dry place inaccessible to children and protected from the sun at a temperature of 15-28 degrees.
The cost of the drug and similar means
How much is a medicine like Magvit? The price of this complex is about 450-550 rubles. If this drug was not in the pharmacies of your city, then it can be replaced with one of the following means: Magnelis B6, Magnesium plus B6, Magnerot, Magnesium Diasporal 300.
The listed drugs have their own characteristics. Therefore, you can use them together with Magvit only on the recommendation of a doctor.
Consumer Reviews
The drug "Magvit" is not the most popular product that contains magnesium and vitamin B6. However, there are a large number of reviews about it.
According to consumers, this medication effectively copes with its task. It eliminates the deficiency of magnesium in the body, which immediately affects the general condition of a person.
It should also be noted that there are negative reviews about the drug in question. Some patients claim that taking this medication often causes digestive upsets. Moreover, many consumers are extremely unhappy with the price of this tool. In their opinion, it is too high.