What are the properties of the drug "Idrinol"? Instructions for use and pharmacological characteristics of this drug will be presented in this article. We will also tell you about in what form the medication mentioned is released, how much it costs, what side effects occur after its use, are there any contraindications, etc.
The composition of the product, its form, description and packaging
In what form is the drug “Idrinol” released? Instructions for use inform us that this drug goes on sale in the form of a solution intended for parabulbar, as well as intravenous administration.
The medication in question is a colorless transparent liquid. Its active ingredient is meldonium dihydrate. As an auxiliary substance, distilled water is used.
The drug solution is sold in ampoules (1 ml), which are placed in plastic cell packs (5 pieces each), and then in cardboard packs.
Pharmacodynamics of the drug
What is a drug like Idrinol? The instruction for use states that its active substance (meldonium) is a structural analogue of gamma-butyrobetaine, that is, an element that is present in every cell of the human body.
Meldonium is able to suppress gamma-butyrobetaine hydroxygenase, reduce the synthesis of carnitine, transport fatty acids (long chain) through cell membranes, and also prevent the accumulation of activated forms of fatty non-oxidized acids, that is, derivatives of acylcoenzyme A and acylcarnicine.
Operating principle
How does the medication “Idrinol” affect the human body? The instructions for use contain information that with such a deviation as ischemia, the drug in question is able to balance the processes of oxygen delivery, its consumption in cells, and also prevent the violation of ATP transport. Along with this, the drug activates glycolysis, which proceeds without the consumption of O 2 . After lowering the concentration of carnitine, gamma-butyrobetaine, which has a vasodilating effect, begins to be synthesized intensely.
The principle of action of the drug determines its pharmacological effects: a decrease in signs of physical and mental overstrain, a marked increase in performance, activation of humoral and tissue immunity.
It should also be noted that this medication has a cardioprotective effect. With ischemic damage to the myocardium (acute), it is able to slow down the formation of zones of necrosis, as well as shorten the rehabilitation period. During heart failure, the drug increases exercise tolerance, improves myocardial contractility and reduces the frequency of seizures. In chronic and acute ischemic cerebral circulatory disorders, the drug is able to improve blood circulation (including in the focus of ischemia). It should also be noted that the agent in question is highly effective in the case of vascular pathologies of the fundus. In addition, this medicine quickly eliminates disorders in the functioning of the nervous system in patients with chronic alcoholism (especially during withdrawal).
Pharmacokinetics of the drug
How long does the absorption of Idrinol take? Instructions for use, reviews of pharmacists inform patients that the highest concentration of this drug in the blood is achieved almost immediately after administration. In the human body, it is metabolized with the formation of two main metabolites. They are excreted through the kidneys. The half-life of the drug is approximately 4-6 hours.
Indications
Prescription drugs can not be purchased at the pharmacy without an appropriate document, only at will. The medication "Idrinol" refers specifically to such medical devices. What is it for? According to the attached instructions, this drug must be used in the following pathological conditions:
- in the complex treatment of cerebrovascular accidents of an acute nature (cerebrovascular insufficiency and ischemic stroke);
- with reduced performance, as well as physical stress (including those involved in sports);
- as part of the complex treatment of coronary heart disease (myocardial infarction and angina pectoris), as well as chronic cardiomyopathy of dishormonal and heart failure;
- for the treatment of hemophthalmus and hemorrhage in the retina of various origins, thrombosis of the central retinal vein, as well as its branches, retinopathy of various origins (hypertensive or diabetic);
- for the treatment of withdrawal syndrome arising from chronic alcoholism (in combination with specific therapy).
Contraindications
In what conditions can Idrinol be used? Reviews of experts suggest that this drug is not recommended for patients with hypersensitivity to the active substances of the drug, with increased intracranial pressure (with intracranial tumors and impaired venous outflow), as well as under the age of 18 years (since the safety and effectiveness of the drug have not been established )
It should also be noted that patients with impaired renal and hepatic function should use the medication in question with extreme caution.
Dosage of the drug and methods for its administration
When should Idrinol be used, the price of which is presented a little lower? Due to the possible exciting effect, the drug is recommended to be administered in the first half of the day.
As part of a comprehensive treatment for cardiovascular pathologies, a medication is prescribed intravenously in 0.5-1 g (i.e. 5-10 ml of solution) or parabulbular in 100 mg / ml. The indicated dosage can be used immediately or divided into two injections.
The course of treatment with this drug is 10-14 days. Repeated courses are prescribed only by a doctor (usually 3 times a year).
In case of circulatory disturbance of the brain (in the acute phase), the drug is administered parabulbally at 100 mg / ml or intravenously at 500 mg (i.e. 5 ml of solution). Injections are carried out once a day for 10 days.
With reduced performance, as well as physical overstrain, the drug is prescribed intravenously at 500 mg (i.e. 5 ml of solution) or parabulbarno at 100 mg / ml once a day. The course of therapy is 2 weeks.
With the withdrawal syndrome, which manifests itself in chronic alcoholism, the drug is prescribed intravenously at 500 mg (i.e. 5 ml of solution) or parabulbarno at 100 mg / ml twice a day. The duration of therapy is 10-14 days.
For ophthalmopathology, the drug is used parabulbularly at 50 mg or intravenously at 0.5 ml for 10 days, including as part of combination therapy.
Side effects
How is Idrinol medication tolerated by patients? Injections almost never cause side effects. However, in rare cases, some patients still complain of poor health. The most common reactions are:
- Nervous system (central): psychomotor agitation.
- Vascular and heart: decreased or, conversely, increased blood pressure, tachycardia.
- Digestive tract: dyspeptic disorders.
- Allergy: rash, itching, flushing of the skin, angioedema, eosinophilia.
- Others: general weakness.
The drug "Idrinol": analogues and cost
The drug in question has many analogues. Among the most effective, the following funds can be distinguished: Angiocardil, Mildronate, Vazomag, Mildroxin, Cardionate, Midolat, Medatern, Melfor, Meldonium.
How much is Idrinol medicine? The price of this drug is not very high. On average, for 5 ampoules of medication you will have to give about 150 Russian rubles.
Reviews
What do patients say about a drug like Idrinol? Reviews say that this drug copes well with the task. Doctors say that if you use it according to your indications, it treats acute cerebrovascular accidents, coronary heart disease, as well as withdrawal symptoms in chronic alcoholism quite effectively. In addition, this medication well improves performance and eliminates physical stress.
It should be noted that the majority of patients are pleased with the low price of the drug.
Terms, storage conditions and vacation
Prescription drugs, which, in fact, include the Idrinol medication, can not be used at your own discretion. They should be prescribed only by a doctor.
The drug in question belongs to list B. The medicine should be stored at a temperature not exceeding 26 ° C in a place inaccessible to children. The medication should not be frozen. The shelf life of the drug is three years.