The drug "Betadine" is a vaginal suppository torpedo-shaped, homogeneous structure and dark brown color, containing two hundred milligrams of the active substance (povidone-iodine). In addition to the main substance, the suppository also includes an auxiliary - macrogol-1000.
The pharmacokinetics of the drug "Betadine" (suppository) instructions for use are described as follows.
The iodine contained in the medicine is rapidly absorbed through the mucous membrane, which leads to an increase in its level in the blood (without negative consequences for a healthy thyroid gland). It is excreted almost completely by the kidneys, and its half-life is about two days.
The pharmacodynamics of the drug "Betadine" (suppository), the instruction describes as follows. The bactericidal effect of this drug is associated with the release of free iodine during the equilibrium reaction. It inactivates and destroys the enzymes and proteins of bacterial cells, entering into oxidative reactions with them. This drug is able to destroy most microorganisms in less than a minute, and most of the damage it does to them in fifteen to thirty seconds. Entering into the reaction, iodine loses its color, which indicates the effectiveness of the effect. It is able to destroy a wide range of both gram-positive and gram-negative bacteria, protozoa, viruses, fungi and spores. These suppositories contribute to the speedy restoration of the normal microflora of the vagina, as well as the disappearance of itching and burning.
Indications for use of the drug "Betadine" (suppository) instructions for use give such: acute and chronic colpitis, nonspecific and mixed infections, fungal infections, genital herpes, and so on.
The medication is used to treat the vagina before and after surgical interventions, diagnostic and obstetric procedures.
For this drug, instructions for its use provide the following doses and method of use. The drug "Betadine" (vaginal suppositories) is administered as deeply as possible. Before the introduction of a candle, it is recommended to moisten with water to improve the dissolution of the active substance and to prevent the occurrence of local irritation. For the treatment of acute vaginitis, the drug must be used once a week, once or twice a day, and for chronic and subacute vaginitis, once a day for two weeks (if necessary, longer). During the course of treatment, it is recommended to use sanitary pads. Use Betadine suppositories for menstruation is allowed. Suppositories are introduced one at a time deep into the vagina at night before bedtime.
Side effects for the drug "Betadine" (suppository) instruction names the following. Allergic manifestations are possible, such as redness, itching, blisters, very rarely anaphylactic reactions. Hyperthyroidism is also sometimes observed (in individuals with a predisposition to it). The drug is contraindicated for persons with hypersensitivity to its components, as well as suffering from hyperthyroidism or other pathologies of the thyroid gland, herpetiform dermatitis Dühring.
When using the drug in conjunction with preparations containing toluidine and silver, as well as with hydrogen peroxide, a mutual decrease in their effectiveness inevitably occurs.
Special instructions when conducting courses of treatment with this medication
The use of the drug affects the results of studies of the thyroid gland, which makes it impossible to correctly diagnose its pathologies. It is undesirable to allow its long-term use in parallel with lithium preparations. Avoid contact with eyes. You can not use this medication from the third month of pregnancy until the termination of breastfeeding.