What dosage is prescribed Signicef medication (eye drops)? Instructions for use, price and indications of the mentioned drug will be presented in this article. Also in it you will find information about what patients say about this remedy, whether it has analogues, side effects and contraindications.
Composition, description and packaging
The drug "Signicef" (eye drops), the instructions for use of which are enclosed in a cardboard package, contain such an active substance as levofloxacin hemihydrate. As additional components, sodium chloride, hydrochloric acid, benzalkonium chloride, hypromellose, sodium hydroxide and water are used.
The medication in question in the form of a clear liquid of light yellow color goes on sale in dropper bottles made of plastic.
Pharmacodynamics of the drug
How does the Signicef medication (eye drops) work? Instructions for use states that the drug is an antimicrobial and antibacterial agent.
Its active substance inhibits topoisomerase IV and DNA gyrase, and also inhibits DNA synthesis, and prevents cross-linking of breaks and DNA supercoiling. It should also be said that the medication in question is capable of provoking morphological changes in the cytoplasm, membranes and cell walls of bacteria.
Eye drops adversely affects both gram-positive and gram-negative aerobes. In addition, they are active against Chlamydia trachomatis.
After using the drug, its active component accumulates in the tear film. At the same time, the concentration of the drug substance in the tear fluid quickly reaches high levels and lasts for six hours.
Indications
What diseases should be used with the Signicef medication (drops)? Instructions for use, reviews of ophthalmologists say that the drug in question is often used for:
- treatment of infections of the anterior segment of the eye and adnexa, which was provoked by bacteria sensitive to levofloxacin;
- the need for preventive measures after eye surgery;
- local therapy for infectious eye diseases that have been triggered by bacteria susceptible to levofloxacin.
Contraindications to the use of eye drops
What contraindications do you need to know before using the drug “Signicef” (eye drops)? The instruction for use states that this medication should not be prescribed for:
- tendon lesions;
- hypersensitivity to the elements of the drug;
- previous treatment with quinolones;
- breastfeeding;
- epilepsy;
- pregnancy.
Also, do not use eye drops for infusion. With caution, this remedy is prescribed in childhood.
The drug "Signicef" (eye drops): instruction
Prices and analogues of the medication in question will be presented at the end of the article.
The instruction reports that this drug should be started within the first two days after the onset of signs of the disease. The drug is instilled in the eyes affected by the infection in the amount of 1-2 drops with an interval of 120 minutes.
The maximum frequency of use of this medication is 8 times a day. 2 days after the start of treatment, the drug begins to be used in the same dose, but already 4 times a day.
The duration of therapy depends on the characteristics and severity of the disease. Usually, treatment lasts for 5 days.
Before applying the drops, the patient needs to tilt his head back, and then pull the lower eyelid. The medicine should be instilled into it, and then for a few minutes to close your eyes.
To prevent the drug from entering the lacrimal duct, the inner edge of the visual organ must be pressed with a finger and kept in this state for 1-2 minutes. It is forbidden to blink.
As for the remains of eye drops, they are removed with a clean cloth, but without contact with the eyes.
Adverse reactions
Side effects associated with the use of the drug in question are extremely rare. As a rule, such reactions are characterized by moderate or mild severity and after a while pass on their own.
So what are the undesirable effects of the drug "Signicef"? Instructions for use (the description of the drops was presented above) indicates that this tool can provoke the appearance of the following ophthalmic disorders:
- burning in the eyes, matting of the eyelids, worsening visual acuity;
- eye pain, papillary conjunctival reaction, swelling of the eyelids;
- conjunctival follicles, pruritus, erythema of the eyelids, conjunctival infection;
- chemosis, photophobia, dry eyes.
Sometimes anaphylactic and allergic reactions are observed in the immune system in patients.
As for the central nervous system, dizziness, drowsiness, headaches, paresthesia, confusion, fear, weakness, motor disorders, anxiety, insomnia, depression, hallucinations and convulsions can be observed on its part.
Rhinitis, thoracic and mediastinal disorders may also occur.
Overdose cases
In case of accidental ingestion of eye drops, toxic effects on the body are excluded. This is due to the fact that the amount of levofloxacin in the drug is too small.
If a local overdose has occurred, then the patient may experience adverse reactions. In this case, the use of the drug should be discontinued, and rinse the eyes thoroughly with warm water.
Drug interaction
The drug "Signicef" reduces the effectiveness of agents that inhibit intestinal motility, as well as aluminum-containing and magnesium-containing antacid drugs, sucralfate and iron salts. The interval between the use of these medicines should be two hours.
The drops in question increase the half-life of Cyclosporin.
The excretion of levofloxacin is significantly slowed with the simultaneous use of drugs that inhibit tubular secretion, and Cimetidine.
Special recommendations
Signicef eye drops are not recommended for use while wearing soft contact lenses due to the presence of benzalkonium chloride preservative in the preparation.
To avoid the ingress of dirt into the vial, do not allow the dropper to come in contact with the mucous membranes of the eyes.
Price, similar drugs
The average cost of the funds in question is about 220 rubles.
As for similar drugs, they include the following: Oftaquix, Glevo, Lebel, Levobaks, Levogrin, Levolet, Levotor, Levofast, Loksof, Novoks , "Remedy", "Phloxium."
Eye Drop Reviews
Eye drops "Signicef" (instructions, price, reviews are described in this article) are a very popular drug. Reviews about them are mostly positive.
Patients talk about the high efficiency of the solution. It quickly treats infectious diseases of the eyes, and is also great for prevention.
Among the negative responses can be noted those in which patients complain about the high cost of the medication and the impossibility of its use during breastfeeding and when carrying a child.