The discovery of the antibacterial action of the molds from which penicillin was made was a real revolution in medicine. But over time, pathogenic microflora adapted to the action of this drug. This forced scientists to develop synthetic analogs of penicillin, one of which was Flemoxin Solutab. Instructions, a description of the drug will help to avoid its negative effects on the body and side effects.
The active substance of the drug
The composition of one tablet "Flemoxin" includes acid-resistant amoxicillin in the form of amoxicillin trihydrate at 125, 250, 500 and 1000 milligrams. This substance has a strong bactericidal effect. Amoxicillin preparations are also used against gram-positive and gram-negative bacteria. Sometimes used to combat intestinal infections. But in the latter case, it is less effective.
Dosage form, composition
What is Flemoxin Solutab (500 mg)? Instructions for use describe the drug in various dosages (125 and 250, 1000 and 500 mg) as oval tablets with a light yellow color. On each side of the tablet is the company logo and digital designation, and on the other, the risk.
In the manufacture of the preparation, such auxiliary substances as monocrystalline cellulose, vanillin, dispersible cellulose, magnesium stearate, crospovidone, saccharin, flavorings were used.
The drug is intended for systemic use and is a medication of a wide spectrum of action.
Pharmacological effect on the body
How does Flemoxin Solutab affect the body? The instruction says that after taking the active substance of the drug - amoxicillin - almost everything is absorbed in the shortest possible time (almost 93 percent). Moreover, the absorption of the drug is in no way associated with food intake.
In blood plasma, the maximum amount of the drug is detected one to two hours after administration. After ingestion of the drug "Flemoxin Solutab 500 mg" (the instructions for use confirm this), the researchers noted the maximum concentration of amoxicillin after 2 hours. This maximum is 5 μg / ml. If for some reason the dose of a medical product decreases or increases, then its concentration, respectively, decreases or increases.
Twenty percent of the substance binds to plasma proteins. The therapeutic effect is achieved almost always, since the drug penetrates perfectly into the intraocular fluid, bones, mucous membranes, sputum. Amoxicillin gets into the bile in two, or even four times more than in plasma. Twenty-five to thirty percent of flemoxin from its concentration in the blood of a pregnant woman is found in the umbilical cord and amniotic substance.
Poor penetration of the active substance through the blood-brain barrier was noted: its amount in the cerebrospinal fluid does not exceed twenty percent when consumed.
The drug is excreted by the kidneys. Eighty percent of the active substance is processed by tubular excretion, the remaining twenty are filtered by glomeruli. Healthy kidneys eliminate amoxicillin an hour and a half. In children under six months, the half-life is three to four hours. Violations in the liver do not affect the elimination half-life of the drug.
Pharmacodynamics
"Flemoxin Solutab" (tab. 500 mg 20 pcs., Like other dosages of the drug) is an acid-resistant bactericidal antibacterial agent with a wide spectrum of action. Relate it to a group of semi-synthetic penicillins.
It has a detrimental effect on many gram-negative and gram-positive microorganisms, such as most varieties of streptococci, clostridia, staphylococci, helicobacteria, colic Escherichia, protea, salmonella, cholera vibrio.
In what cases is the drug prescribed
In what cases is prescribed "Flemoxin Solutab" (500 mg)? The instructions for use confirm (this also applies to other dosages of the drug) that the drug is effective:
- with infectious processes in the respiratory tract;
- with infectious diseases of the genitourinary organs;
- for the treatment of gastrointestinal infections;
- with skin infections and infectious processes in soft tissues.
To whom the use of the drug is contraindicated
"Flemoxin Solutab" (tab. 500 mg n20), the instructions confirm this, it has not only advantages, it also has its contraindications. This is true for other dosages of the drug. The drug is not prescribed or is prescribed with great care in such cases:
- if the patient has had an allergic reaction to him or other antibiotics of this series;
- patients with lymphocytic leukemia or infectious mononucleosis;
- children under six years of age are prescribed with caution in the form of a suspension;
- with renal failure;
- with diseases of the gastrointestinal tract, especially arising from the use of antibiotics;
- pregnant women or during lactation are prescribed if the need to use the product exceeds the possible risks.
Use of the drug by adults
Adults and children over ten years of age and forty kilograms of weight are most often prescribed Flemoxin Solutab 500 mg. Instructions for use states the need to take the drug three times a day. If the
infectious process proceeds severely and with complications, a dosage of 0.75 to 1 gram 3 times a day is allowed. Gonorrhea without complications in adults requires the appointment of three grams of the drug at a time. Women are prescribed the same dose repeatedly.
Infectious ailments of the stomach, intestines and biliary tract, as well as gynecological diseases of an infectious nature, are treated with three times a dose in a dosage from one and a half to two grams or four times a day - one and a half grams at a time.
Adults with leptospirosis are treated with a four-fold intake of Flemoxin Solutab, 0.5-0.7 grams each. Treatment should last from six to twelve days.
Carriage of Salmonella requires three times a half to two grams for two to four weeks.
To avoid endocarditis with small surgical interventions, three to four grams of the drug is prescribed an hour before the operation. If there is a need for repeated use of the drug, then it is prescribed after eight to nine hours in the same dosage.
In case of impaired renal function, the interval between doses should be up to 12 hours. With more serious violations, reduce the dose. If the patient has anuria, the maximum dose should not exceed two grams.
"Flemoxin Solutab" for children - dosage
In most cases, this drug is used as a suspension for children. How is Flemoxin Solutab used for children? Dosage and purpose depends on the age, weight of the patient, the severity of the infection process. If the child is from five to ten years old, the drug is prescribed in a dose of 250 mg, from two to five years - 125 mg, up to two years, 200 mg are prescribed. In severe cases of the disease, 60 mg / kg is used three times a day. The course of treatment with this medication is from six to twelve days.
For newborns and premature babies, the dose is reduced or the interval between doses is increased. For the prevention of endocarditis in small surgeries, an hour and a half to two grams is prescribed an hour before the procedure. If necessary, reappoint eight to nine hours after surgery.
What side effects may accompany the use of the drug
Whatever the perfect medicine, no matter what natural ingredients it is created, there are risks of side effects that can affect the patient's condition.
- Allergic reactions can give any dosage of the drug, including Flemoxin Solutab 500 mg 20, the price, the instructions for which are almost the same in all used dosage forms. Redness of the skin, rashes in the form of erythema, angioedema may also be observed.
- Serum sickness and anaphylactic shock, fever, eosinophilia, arthralgia are rare.
- From the digestive organs, nausea, dysbiosis, diarrhea, vomiting, a change in taste, pseudomembranous enterocolitis are possible. ALT and AST may increase.
- Changes in the nervous system: sleep disturbances, anxiety, depression, pain and dizziness, episindrome, impaired consciousness, ataxia can be noted.
- Laboratory indicators change: the number of leukocytes, erythrocytes decreases, hemoglobin decreases, neutropenia is noted.
- Possible respiratory failure, increased heart rate, nephritis, vaginal candidiasis, an even greater development of infection (in patients with chronic processes and reduced immunity).
- An overdose of the drug manifests itself in the form of diarrhea, vomiting and nausea, due to which a violation of the water and electrolyte balance can be observed. Prescribe gastric lavage, saline laxatives, activated charcoal, sometimes hemodialysis.
"Flemoxin Solutab": reviews, analogs, application
Patients rate this drug as very effective and relatively safe. It is bioavailable, so the effect of it is very quickly manifested. After the start of treatment, the condition of adults and children improves during the first day. Depending on the dosage and purpose, Flemoxin Solutab is very rapidly absorbed into the blood. Its action lasts for eight hours. In this case, the concentration of the substance is noted 15 minutes after use.
According to experts, for children this antibiotic is one of the safest. It is used from early childhood as prescribed by a doctor.
This drug has many synonyms, that is, drugs that are made on the basis of amoxicillin. But there are also some medicines with another active substance, but they are used for the same health problems as Flemoxin Solutab. Such drugs are called analogues of the above. The active substances in them are also antibiotics, semisynthetic penicillins. They are used for sepsis, abscesses, infections of the ENT organs and respiratory tract, genitourinary tract, skin, gastrointestinal tract, soft tissues and so on.
Such analogues of the drug include:
- "Azlocillin" - the active substance azlocillin.
- "Ampic" - acts with the help of ampicillin.
- "Geopen" is the main substance carbenicillin.
- "Isipen" - the active substance piperacillin.
- "Penglob" - affects the body with bacampicillin.
- "Flucloxacillin" - the active substance has the same name.
Analogues of the drug, especially antibiotic, must be discussed with your doctor. This is very important, since only the specialist determines the dosage, the nature of the treatment and the duration. He also knows better which active substance is suitable in a particular case.
Features of the use of the drug, price
For most patients, indications for the Flemoxin Solutab preparation are interesting, instructions for use, price, description, features of use.
If drug treatment is carried out in courses, the function of the kidneys, liver, and blood formation should be monitored.
If the patient is sensitive to the penicillin group, cross-allergic manifestations may occur.
If mild diarrhea occurs during treatment, medications that reduce intestinal motility should be avoided. If severe diarrhea occurs, you should seek advice from a medical institution. After the disappearance of clinical manifestations, it is recommended to take Flemoxin Solutab for another three to four days.
The drug can reduce the contraceptive effect of oral contraceptives, therefore, during its administration, additional contraception should be taken into account. It also does not mix well with aminoglycosides, indirect anticoagulants, methotrexate, digoxin, alopurinol, diuretics, oxyphenbutazone.
Before use, it is important to familiarize yourself with the features of the drug "Flemoxin Solutab." Instructions for use, reviews will help to avoid undesirable consequences.
Drug prices in different cities range from 176 rubles (in Nizhny Novgorod) and up to 228 rubles (in Novosibirsk). In the capital, "Flemoxin Solutab" can be purchased at a price of 191 rubles. In St. Petersburg, it costs an average of 184 rubles.
Do not forget that the instructions for the use of the drug "Flemoxin Solutab" are mainly made for the doctor. And only he can prescribe or cancel the drug. Avoid self-medication!