Serious complications can occur if the chronic and acute respiratory tract diseases are not treated properly. Therefore, at the first signs of the disease, you should immediately contact a narrow specialist. After diagnosis, the doctor must prescribe the appropriate medication.
One of the most popular drugs against cough, pneumonia, bronchitis, laryngitis, etc. is the medication Pulmobriz. Instructions and indications for the use of this tool will be presented below. In addition, you will learn about what doctors and patients say about this medicine, whether it has contraindications and analogues.
Release form, packaging and composition
There are several forms of Pulmobriz. Customer reviews report that this product can be purchased in the form of:
- Powder for the preparation of oral suspension. Available in sachets of 2 g. The active ingredients are acetylcysteine and ambroxol hydrochloride. As auxiliary substances, ethylene diamine tetraacetic acid, sodium saccharin , sodium benzoate, aspartame, vanillin flavor, mannitol, povidone, sucralose, tartrazine dye and sucrose are used.
- Pills. The active components of this form are also acetylcysteine and ambroxol hydrochloride (+ additional substances). The drug goes on sale in contour packs.
Pharmacological characteristics
What is remarkable for the Pulmobriz medicine? Instructions for use, reviews of specialists report that this drug is a combination medicine that is used for colds and cough. Its high efficiency is due to the ingredients that make up the composition.
Drug properties
Ambroxol hydrochloride is a kind of expectorant and mucolytic agent. It has a pronounced anti-inflammatory, slight antitussive, antioxidant and immunomodulatory effects.
The substance under consideration is able to stimulate serous cells of the glands of the bronchial mucosa, increase the volume of the mucous secretion and change the disturbed ratio of the mucous and serous components. This effect normalizes the rheological parameters of sputum, significantly reducing its adhesive properties and viscosity.
It should also be noted that ambroxol hydrochloride is able to stimulate the motor activity of the epithelium of the (ciliated) bronchi, preventing its adhesion and improving the evacuation of (mucociliary) sputum. In addition, this substance increases the amount of surfactant in the lungs and prevents its destruction in pneumocytes.
According to experts, Ambroxol hydrochloride does not cause bronchial obstruction. On the contrary, it improves the work of external respiration, and also reduces the hyperreactivity of the muscles of the bronchi in people with asthma.
This substance has antioxidant properties and anti-inflammatory effect. It stimulates local immunity and renews the natural layer of surfactant.
During treatment with Pulmobriz, patients no longer complain of coughing and sputum.
As for acetylcysteine, it is also an expectorant and mucolytic substance. Due to the free sulfhydryl group, it breaks the bisulfide bond of sputum mucopolysaccharide. This leads to a decrease in the viscosity of bronchial secretions, as well as to an increase in mucociliary clearance. In addition, due to the binding of free radicals, acetylcysteine has an antioxidant effect. It enhances the synthesis of glutathione, which is the main factor in detoxification. Such properties of the drug substance are essential for the treatment of acute poisoning with phenols, paracetamol, aldehydes and others.
The drug "Pulmobriz": indications for use
Why is the tool we are considering necessary? This medication is used to treat chronic and acute diseases of the respiratory tract, which are accompanied by impaired secretion evacuation and bronchial secretion. Thus, this tool effectively treats acute and chronic bronchitis, COPD, bronchiectasis, pneumonia, asthma, cystic fibrosis, tracheitis and laryngitis.
In addition, the drug in question can be used in patients with shock lung syndrome, for the treatment and prevention of complications arising from surgical interventions on the lungs, as well as for caring for a tracheostomy, after and before bronchoscopy.
Contraindications
Are there any contraindications for such a medication as Pulmobriz? The instruction for use reports that the use of this drug is prohibited when:
- hypersensitivity to acetylcysteine, ambroxol and other ingredients that make up the drug;
- pulmonary hemorrhage or hemoptysis;
- peptic ulcer (in the acute stage) of the duodenum and stomach.
The drug "Pulmobriz" (tablets): instructions for use
Such tablets should be prescribed only by a doctor. He is obliged to examine the patient and choose the most effective treatment regimen.
According to the instructions, the standard dosage of this drug for adults and adolescents over 12 years is one tablet three times a day.
The dose indicated or recommended by the doctor should not be exceeded. Otherwise, unwanted effects may occur.
The course of such treatment should not last more than 5-7 days in a row without consulting a doctor.
Powder Application Method
How should I use the drug "Pulmobriz" (powder)? Instructions for use indicate that before using this medication, the contents of the sachet must be placed in a glass and pour 150 ml of ordinary water. Store the finished solution should not be. You need to drink it right away.
The dosage for adolescents over the age of 12 years, as well as adults is one sachet three times a day. The indicated amount of the drug should not be exceeded.
The duration of therapy should not exceed 5 days without consulting a doctor.
Side effects
What adverse reactions can the drug "Pulmobriz" cause? Reviews of doctors indicate that this tool often contributes to the following adverse events:
- hypersensitivity reactions, including shock and anaphylactic reactions, urticaria, rash, fever, mucosal reactions, dyspnea, angioedema, pruritus, and others;
- dry mouth, stomatitis, salivation, nausea, heartburn, diarrhea, vomiting, abdominal pain, dyspepsia, halitosis, constipation;
- eczema, Stevens-Johnson syndrome, erythema, severe skin lesions, toxic epidermal necrolysis;
- dysuria;
- dry airways, rhinorrhea, bronchospasm (in people with hyperreactivity of the bronchial system associated with AD);
- headache;
- tinnitus;
- arterial hypotension and tachycardia.
What other adverse reactions can the Pulmobriz medication cause? The instructions for use report that, due to the presence of acetylcysteine in the drug, patients rarely experienced bleeding associated with the development of hypersensitivity reactions, hemorrhage and anemia. A decrease in platelet aggregation was also observed, although there is no clinical evidence for this.
Taking the drug in powder form for oral suspension may cause a mild laxative effect due to the content of mannitol in the medicine.
Overdose cases
Currently, there is no evidence of an overdose of acetylcysteine intended for oral administration.
As for ambroxol, it is well tolerated after oral administration in an amount of not more than 25 mg / kg / day. In case of an overdose of this substance, no severe signs of intoxication were noted. Only cases of diarrhea, short-term anxiety and hypersalivation have been reported.
Experts also argue that taking excessive doses of the medication in question can cause hypersalivation, nausea, decreased blood pressure and vomiting.
To treat such conditions, they artificially stimulate vomiting and wash the stomach.
Interaction with other medicines
Is Pulmobriz allowed to combine with other medicines? Instructions for use states that when a combination of this drug with bronchodilators is synergistic.
Acetylcysteine reduces the severity of the hepatotoxic effect of paracetamol. In addition, he can donate cysteine, as well as increase the level of glutathione, which contributes to the detoxification of certain toxic substances and free oxygen radicals.
The use of ambroxol increases the concentration of antibiotics such as Amoxicillin, Doxycycline, Cefuroxime and Erythromycin in bronchopulmonary secretions and sputum.
The combination of this drug with drugs that inhibit cough leads to the accumulation of mucus due to inhibition of the cough reflex.
When combining drugs with such antibiotics: Tetracycline, Ampicillin, and others, their activity decreases. In this regard, the interval between taking these medications should be at least 120 minutes.
Activated carbon worsens the effect of acetylcysteine.
Upon contact of the medicinal powder with rubber or metals, sulfides with a characteristic odor are formed.
Special recommendations
What should the doctor warn about before prescribing Pulmobriz (tablets) to the patient? Instructions for use informs that if there are changes in the mucous membranes or skin, it is necessary to immediately stop treatment and consult a doctor regarding further medication.
Due to the fact that Ambroxol enhances the secretion of mucus, the medication in question is used with extreme caution in case of increased secretion of mucus and impaired bronchial motility.
The use of acetylcysteine dilutes the bronchial secretion. If the patient cannot cough up sputum, then bronchospiration or postural drainage is required.
The composition of the Pulmobriz powder includes aspartame, which is a source of phenylalanine. In this regard, this medication should not be prescribed to patients with phenylketonuria.
Analogs
What can replace the drug "Pulmobriz"? Instructions for use do not provide an answer to this question. You should contact your doctor for it.
According to experts, such drugs as Milistan, Flavamed, Pektolvan Ts, Neo-Bronhol, Abrol, Mukolvan, Ambrobene, Lazoleks, Ambrohexal are classified as analogues of the drug in question "," Lazolvan "," Ambroxol "," Bronchoval "," Ambronol "and others.
Reviews of doctors and patients
Now you know how to use Pulmobriz powder and tablets. Instructions and indications for this medication were presented above.
According to experts, this drug is highly effective. Patients fully agree with them. They claim that within a few days after the start of treatment, the signs of respiratory diseases almost completely disappear.
The only drawback of the drug in question is the presence of a large number of side effects. Although with the right medication and observing all its doses, they do not appear very often.