The birth of children is the main purpose of a woman, programmed by nature. However, modern ecology, constant nervous strain, stress, workload or other problems can provoke infertility in girls. In this case, you have to help the body with medications. For example, doctors may prescribe a remedy such as Ovitrel. Instructions for use of this medication will be described below.
general characteristics
This substance is a recombinant human chorionic gonadotropin, which is no different from natural. This medication is hormonal.
Used in gynecology and reproductology drug "Ovitrel". Instructions for use of the drug is the main document with which the patient should be familiar. This is an imported product. It is made in Italy.
The medicine is sold only by prescription. Hormone therapy cannot be practiced independently, since the patient cannot know the nuances of the action of the substance. In addition, the doctor must make the necessary tests and find out if the drug is suitable for the patient.
Composition and release forms
If you are interested in what Ovitrel consists of, the instructions for use indicate its components:
1. The main active substance is chorionic gonadotropin.
2. Mannitol.
3. Methionine.
4. Poloxamer 188.
5. Sodium hydroxide.
6. Phosphoric acid.
7. Distilled water.
As for the forms of release, there are only two of them:
- The liquid . It can be transparent or slightly yellow. It is placed in a glass syringe. It also has a needle, rubber gasket and protective cap.
- The powder . It is in a glass bottle corked with a rubber cap. In addition, complete with the drug is a solution for diluting the powder. The package may contain one, two or 10 bottles of the product.
Please note that the syringe is used only once.
Pharmacological action and interaction with other drugs
If the doctor prescribed you a remedy such as Ovitrel, the instructions for use will help you understand the features of its action. The substance provokes reduction of egg division, rupture of the follicle and the onset of ovulation, the formation of the corpus luteum, as well as the production of hormones that support pregnancy - estradiol and progesterone.
Such properties of the drug contribute to conception, fixing a fertilized egg in the uterine cavity, normal development of the fetus.
Ovitrel medicine has a rather high bioavailability level - 40%. The half-life of a substance from the body is approximately 30 hours.
As for the interaction of the drug with other drugs, there is no information on this subject. However, if during hormone therapy a woman takes some other drugs, then she must tell the doctor about it.
Indications
If a woman has problems conceiving, she may be prescribed Ovitrel. Instructions for use (photo of the remedy you can see in the article) will tell you about the indications for the appointment of this medication. So, taking the substance is necessary in case of anovulatory or oligovulatory infertility. That is, if a woman of childbearing age is completely absent or ovulation rarely occurs pathologically, without which pregnancy cannot occur.
Most often, the drug is used during in vitro fertilization to stimulate the final maturation of the follicles and the formation of the corpus luteum after it. Often, the remedy is also prescribed for those women who have difficulties with the onset of natural pregnancy, but infertility is not confirmed.
Contraindications
Instructions for use of the drug "Ovitrel" provides for some limitations and contraindications:
- Too high sensitivity to one or more components of the medicine.
- Malignant or benign tumors of the internal genital organs, hypothalamus and pituitary gland.
- Neoplasms or cysts on the ovaries that are not associated with polycystic.
- Vaginal bleeding, the nature of which cannot be determined.
- Breast cancer.
- An ectopic pregnancy, which was detected in the previous 3 months of stimulation.
- The period of breastfeeding or pregnancy.
- Thromboembolism of any vessels.
- Primary ovarian failure.
- Uterine fibromyoma.
- Menopause.
- Severe congenital physical defects of the internal and external genital organs, which cannot be compatible with pregnancy.
When prescribing the drug, it should be especially cautious if the patient has a serious systemic disease, which during pregnancy can go into the acute stage.
Possible adverse reactions
Ovitrel (you have already read the description of the drug) may provoke the onset of side effects. Among them may be:
- Abdominal pain, nausea and vomiting, and in some cases, diarrhea can be observed.
- Breast tenderness, ovarian hyperstimulation syndrome.
- Increased irritability, sensitivity, headache, causeless anxiety, fatigue.
- A slight skin reaction in the form of a rash.
- Swelling and pain at the injection site.
- Light allergy and feeling tired.
As you can see, these side effects are not too strong and can be quickly eliminated. Caution should be taken with hyperstimulation. If this happens, then you may need to suspend the drug for a while.
Features of dosing and rules for the administration of the drug
Scientists have long proved that the Ovitrel medicine is practically the most effective in treating female infertility. The instruction (the description of the drug will help you determine the need for its purchase) provides for such a dosage regimen for IVF: once 250 ÎĽg of the substance is administered subcutaneously 1-2 days after the last administration of FSH.
In anovulatory or oligovulatory infertility, to induce ovulation and luteinization at the end of stimulation of follicular growth, the drug is also administered once 24-48 hours after reaching the optimal level of follicle development. Recommended sexual contact on the day of administration of the drug and the next day.
If you use the product yourself, you must follow some rules for its introduction:
1. During the injection, it is necessary to use antiseptic agents.
2. To begin, on a clean surface, lay out a few cotton swabs and a dialed (finished) syringe. If necessary, the substance must first be diluted. The injection site must be wiped with alcohol.
3. Then immediately inject into the abdomen or front of the thigh. In this case, the skin should be tightened as much as possible. Note that the angle of entry of the needle should be 45 or 90 degrees. It is impossible for the medicine to enter the vein, so be careful as carefully as possible. It is necessary to enter the liquid slowly until the syringe is completely empty. Next, in a circular motion using a swab, massage the injection site.
4. After injection, the syringe must be disposed of. Even if a small amount of the substance is left in it, it can no longer be reused.
What analogues can I use?
I must say that the cost of this foreign drug is quite high. For example, one dose of undiluted powder has a price of 2300 rubles. A ready-made syringe costs almost 2600 rubles. The course of therapy involves more than one injection. This forces patients to look for other options.
If you can’t afford Ovitrel’s medicine, the instruction (analogues may have lower cost with the same effect) tells about such possible substitutes: “Rotted”, “Menogon”, “Menopur”, “Merion”, “Luveris”, “Follitrop” "," Ecostimulin "," Pergoveris ".
Duration and storage conditions
So, the drug should be in the refrigerator at a temperature of 2-8 degrees. It is forbidden to freeze the product. The shelf life of the substance is 2 years, and the dilution solution is 3 years.
If the drug is not in the refrigerator, then the ambient temperature should not exceed 25 degrees. In such conditions, Ovitrel can be stored for only 1 month. If during this time it was not applied, then it can already be thrown away.
Reviews and special instructions for use
In principle, a good opinion about the drug among users can be noted. They indicate the effectiveness of the drug. Subject to the instructions, this drug practically does not cause adverse reactions. Although some women report pain in the abdomen, headache, and nausea.
Before you start taking this medication, you need to carefully examine both partners and establish the true cause of infertility. When prescribing a substance, care must be taken if adrenal insufficiency and hypothyroidism are present.
Each vial or syringe can be used only once. During stimulation, to prevent OHSS, it is necessary to constantly monitor the level of estradiol in the blood, as well as conduct regular ultrasound. During therapy, it is possible to enhance the functioning of the thyroid gland.
Please note that drinking alcohol 24 hours before the administration of the drug and within 14 days after the procedure is strictly prohibited.
After the injection, you can safely drive the car, as the tool does not affect the reaction rate and attention. You need to remember: if you need Ovitrel medicine, the instructions (you already know the evidence) are for informational purposes only. Only a doctor can prescribe it.
That's all that can be said on the topic: "Ovitrel", instructions for use, analogues. "Be healthy!