In the article, we consider the instructions and reviews for the Nexium medication.
It is an inhibitor of H + -K + -ATPase. The manufacturer produces the drug in two pharmacological forms - powder and tablets. Tablets may have a dosage of 20, 40 mg. The shape is oblong, convex, coated. Their color is pink. Tablets with a dosage of 20 mg have a lighter color, 40 mg are darker. One side of the tablet has an engraving indicating the dosage, the other has an inscription. Tablets are packaged in cardboard packaging of 7, 14, 28 pieces.
Another form of the drug is a powder, which is a compressed mass of white. It is used to make the solution. Packed in glass bottles with a volume of 5 ml. Reviews about the "Nexium" are abundant.
Structure
The main active ingredient in Nexium is esomeprazole magnesium trihydrate. The auxiliary components in the manufacture of tablets are: talc, sucrose, E171, macrogol, sodium stearyl fumarate, polysorbate 80, paraffin, crospovidone, macrogol, ethacrylic acid copolymer, methacrylic acid copolymer, triethyl citrate, hypromellose, glycerol monostearate, glycerol monostearate, glycerol monostearate, 2 glycerol monostearate, .
Excipients in the composition of the powder “Nexium” are: disodium edetate dihydrate, sodium hydroxide.
It belongs to the group of proton pump inhibitors.
This is confirmed by the instructions for use with Nexium. Reviews about him are mostly positive.
Pharmacodynamics, pharmacokinetics
Esomeprazole is the S-isomer of omeprazole. It is able to reduce the secretion of hydrochloric acid by the gastric mucosa by inhibiting the proton pump of the parietal cells present in the gastric walls.
"Nexium" is effective when combined with antibiotic drugs that affect Helicobacter pylori, which is often the cause of ulcerative lesions of the stomach.
A decrease in acid production can cause a specific response, which consists in the formation of benign cystic formations, an increase in the level of gastrin in the blood plasma.
The effect on the level of hydrochloric acid develops within 2 hours after the use of the drug. About 90% of esomeprazole binds to plasma proteins. In the body, the active component is metabolized, after which it is evacuated together with feces and urine.
The pharmacokinetics of the active substance in patients with decreased CYP2C19 activity and liver pathologies differs from that in patients of the main group. In this case, the specialist must adjust the dose
Reviews on Nexium tablets will be presented at the end of the article.
Indications for use
Tableted "Nexium" is indicated for use in the following cases:
- Hypersecretion of idiopathic nature.
- Prevention, therapy for bleeding peptic ulcers.
- Prolonged use of NSAIDs, treatment of diseases provoked by the use of NSAIDs.
- Pathological hypersecretion of the gastric glands.
- Peptic ulcer of the duodenum, stomach (prevention, therapy, which can be both independent, and in combination with other drugs).
- Reflux esophagitis of an erosive nature (therapy, supportive care).
A solution intended for intramuscular administration is prescribed to patients who are unable to take the tablet preparation. Indications for its appointment are:
- Peptic ulcers, prevention of bleeding from them after endoscopic hemostasis.
- Gastroesophageal reflux disease.
Contraindications
"Nexium" is contraindicated in patients who have the following physiological, pathological conditions:
- Age to 12 years.
- The use of nelfinavir, atazanavir.
- Hypersensitivity to any of the components that are part of Nexium.
The drug can be prescribed to patients under 12 years of age if gastroesophageal reflux disease is diagnosed.
Severe renal failure is not a direct contraindication to the use of the drug, but caution should be exercised.
Negative impact
According to reviews of Nexium, some negative reactions may develop during the use of the drug:
- Redness, inflammation at the site of intramuscular, intravenous administration.
- Arthralgia, agitation, myalgia, anaphylaxis, stomatitis, bronchospasm.
- Paresthesia, sleep disturbance, allergic manifestations.
- Epigastric pain, constipation, headache, nausea.
If these or any other negative reactions occur when using the medication, it is important to consult a doctor for advice. Probably, the withdrawal of the drug and its subsequent replacement with an analogue will be required.
Using Nexium
You can drink the tablets in their entirety, or previously dissolving in still water. If necessary, the tablet may be administered via a nasogastric tube.
According to reviews taken by Nexium, food intake does not practically affect the effectiveness of the drug, so you can use it at any time. For the purpose of therapy and prevention of ulcerative lesions, the patient is prescribed a double dose of 10 mg. The use of the drug may be combined with other drugs. Therapy takes an average week.
For the purpose of acid suppression, patients are prescribed a daily single dose of 40 mg of the drug for a month.
For the treatment of conditions provoked by the use of NSAIDs, it is indicated to take up to 40 mg. Therapy takes up to 2 months.
If the patient has severe hepatic pathologies, the daily dosage should be no more than 20 mg.
In order to treat erosive reflux esophagitis in children from 12 years old, it is indicated to take 40 mg once a day for a month. In other cases, the use of 20 mg will be sufficient.
If there is a need to replace the tablet form with an injectable one, it is recommended to use similar dosages. Intramuscularly, the solution should be administered for at least 3 minutes. Intravenous administration should be carried out within 10-30 minutes. The powder was previously diluted using a solution of sodium chloride (0.9%). Mixing with other medicines is unacceptable.
The prepared solution can be stored for a maximum of 12 hours, however, experts advise using only freshly prepared solution.
Overdose
With the consumption of 0.28 or more grams, weakness and the appearance of unpleasant sensations in the digestive tract are noted. This is confirmed by reviews of the Nexium.
The drug has no specific antidote. When an overdose occurs, the appointment of symptomatic therapy is indicated.
Interaction with other medicines
When combining the drug with itraconazole, ketoconazole, there is a possibility of disruption of the absorption process of the active component "Nexium".
The effectiveness of omeprazole, nelfinavir, atazanavir when combined with Nexium may decrease. The concentration of the active substance in the blood rises with the parallel use with saquinavir.
The simultaneous use with medicines, the absorption of which is affected by CYP2C19, causes an increase in their effect. Such drugs are drugs based on phenytoin, citalopram, clomipramine, diazepam, imipramine.
It is important to exercise caution when using Nexium in patients suffering from epilepsy. Antiepileptic medicines do not combine well with the active substance Nexium.
It is necessary to carefully combine the drug with cisapride, warfarin.
According to reviews, Nexium analogues are no less effective.
Analogs
If necessary, Nexium can be replaced with drugs that are its analogues. The most popular medicines are: “Ultop”, “Razol”, “Pariet”, “Panum”, “Robimak”, “Normitsid”, “Omez”, “Ozol”, “Kontrolok”, “Geerdin”, “Veloz”, “ Esomeprazole ”,“ Barol ”,“ Emanera ”,“ Esomealox ”,“ Esolong ”,“ Esox ”,“ Esonexa ”,“ Esoxium ”,“ Nekspro ”.
It is important to remember that any of these Nexium analogues has its own number of contraindications and is able to provoke the development of specific negative manifestations. Therefore, any replacement of the medication should be agreed with the doctor.
Cost
The average cost of Nexium 40 mg tabletted is about 1750 rubles per pack containing 14 tablets.
A package of 14 tablets with a dosage of 20 mg will cost about 1310 rubles.
Granules, pellets from which the solution is prepared, cost an average of 2061 rubles per pack.
Reviews about the "Nexium"
Proton pump regulators are by far the most effective drugs that can regulate acidity in the digestive tract. Patients respond positively to the drug - it is well tolerated, the therapeutic effect develops quickly, negative manifestations practically do not occur. The only drawback of the drug, users consider it a rather expensive cost.
There are also reviews of doctors about Nexium. This tool has worked well. Specialists often prescribe it for various diseases of the gastrointestinal tract. The drug is effective, but if necessary, can easily be replaced by an analog.