Do you know what Nise (tablets) helps from? If you do not possess such information, then we will present it in the materials of this article.
The packaging of the drug and its composition
About what “Nise” (tablets) helps from, we will describe below. The active ingredient of this drug is nimesulide. It also includes components such as microcrystalline cellulose, aspartame, calcium phosphate, colloidal silicon dioxide, corn starch, magnesium stearate, sodium carboxymethyl starch, pineapple flavor and talc.
On sale, the medication in question comes in blisters of 10 tablets, packed in cardboard packs.
The principle of action of the drug
Before answering the question of why Nise helps (tablets), it is necessary to tell how this drug works.
According to the instructions, this is an NSAID that selectively inhibits COX-2, that is, an enzyme involved in the synthesis of prostaglandins - mediators of pain, inflammation and edema. In addition to anti-inflammatory properties, the drug in question exhibits antipyretic and analgesic effects.
It can not be said that this medication inhibits (reversibly) the formation of prostaglandin E2 in the ascending paths of the nociceptive system and the focus of inflammation, as well as in the ways of conducting impulses (pain) in the spinal cord.
The Nise drug, the analogues of which are listed below, reduces the concentration of prostaglandin H2 (short-living), from which, under the influence of prostaglandin isomerase, prostaglandin E2 arises. A decrease in the concentration of the latter leads to a decrease in the degree of activation of EP-type receptors (prostanoid), which is expressed in anti-inflammatory and analgesic effects.
It should also be noted that, to a small extent, the drug in question affects COX-1. Under physiological conditions, it almost does not prevent the occurrence of prostaglandin E2 from arachidonic acid. Due to this, the number of side effects of the drug is reduced.
The main properties of the drug (NSAIDs)
The drug "Nise" is able to suppress platelet aggregation. This happens by inhibiting the synthesis of thromboxane A2 and endoperoxides. In addition, it inhibits the release of histamine, and also reduces the degree of bronchospasm, which was caused by exposure to acetaldehyde and histamine.
Experts have proven that nimesulide inhibits well the synthesis of urokinase and interleukin-6, preventing the destruction of cartilage tissue. In addition, it inhibits the synthesis of metalloproteases, preventing the destruction of collagen and proteoglycans.
According to the instructions, by reducing the activity of myeloperoxidase, the drug in question exhibits antioxidant properties and slows down the formation of (toxic) O 2 decay products. It interacts with glucocorticoid receptors and activates them, which enhances the anti-inflammatory effect.
Drug kinetics
After ingestion, the analgesic Nise is absorbed from the intestine. Eating reduces the absorption rate of the drug, but does not affect its degree.
The peak concentration of nimesulide in the blood is reached after 2.6 hours. Its connection with proteins reaches 95%.
This drug penetrates into all tissues of the female genital organs. In addition, it is found in the acidic environment of the focus of inflammation and synovial fluid.
Nimesulide metabolism is carried out in the liver. Its half-life is 5 hours. It is excreted mainly by the kidneys, as well as with bile.
Indications for taking pills
What helps “Nise” (tablets)? The drug in question is prescribed for:
- radiculitis, rheumatoid arthritis, sciatica;
- lumbago, osteoarthrosis, articular syndrome with rheumatic disease and exacerbation of gout;
- psoriatic arthritis, arthralgia, ankylosing spondylitis;
- arthritis of various origins, osteochondrosis with radicular syndrome;
- inflammation of the ligaments, myalgia of non-rheumatic and rheumatic origin, bursitis, inflammation of the tendons;
- pain syndrome of various origins (including with injuries, in the postoperative period, with toothache, algodismenorea, headache);
- inflammation of the musculoskeletal system, as well as soft tissues.
It should also be noted that Nise helps with temperature. This drug is used for fever of various origins, including inflammatory and infectious diseases.
Contraindications NSAIDs
The drug "Nise" during pregnancy is prohibited. Also, it should not be used when:
- "Aspirin triad";
- erosive and ulcerative lesions of the gastrointestinal tract (with exacerbation);
- breastfeeding;
- GI bleeding;
- impaired liver function;
- in children under two years of age;
- severe renal failure;
- hypersensitivity.
With extreme caution, this remedy is prescribed for type II diabetes mellitus, arterial hypertension and heart failure.
How to take Nise?
The medication in the form of tablets is prescribed only inside. Adult patients are advised to take 100 mg twice a day. The maximum dosage of the drug per day is 400 mg.
As for dispersible tablets, before taking such a medicine, it should first be dissolved in 5 ml of ordinary water (in 1 dessert spoon). Use this tool at the end of the meal or after eating.
For children, the drug is not prescribed in tablets. For them, there is another form of medication - suspension. It is recommended to be taken at the age of two years.
Side effects
The Nise drug, the dosage of which was presented above, can cause undesirable reactions such as:
- heartburn, toxic hepatitis, nausea, thrombocytopenia, vomiting;
- agranulocytosis, pain in the stomach, anemia, diarrhea, leukopenia;
- erosive and ulcerative lesions of the digestive tract, headaches, increased activity of liver transaminases;
- anaphylactic shock, dizziness, skin rash;
- prolonged bleeding time, bronchospasm, hematuria, fluid retention.
Overdose cases
What symptoms occur when taking a large number of Nise tablets? The dosage of this medicine should be determined by your doctor. If the drug is accidentally swallowed (in large quantities), the patient may develop the following symptoms: convulsions, increased blood pressure, irritation of the gastrointestinal mucosa, impaired renal function, liver failure and respiratory depression.
To eliminate such conditions, the patient is washed with a stomach, prescribed charcoal, and symptomatic therapy is performed.
Drug Interactions
With the simultaneous oral administration of the Nise drug with diuretics, Digoxin, Phenytoin, antihypertensive agents and lithium, as well as with other NSAIDs, cyclosporine, anticoagulants, methotrexate, hypoglycemic drugs (inside), the patient may manifest drug interaction (from due to the competition of these products for protein binding).
The drug "Nise": analogues and reviews
You can replace the drug in question with such medicines as Nimulide, Aponil, Arkoxia, Mesulide, Meloxicam, Nimesil, Movalis, Nimesulide, Denebol, Nimica.
Most consumer reviews about the drug in question are positive. According to them, Nise quickly relieves pain, and the drug is also used as a highly effective anti - inflammatory agent. Although some patients claim that this medication has one significant minus. It very often causes adverse reactions such as dizziness, weakness and digestive problems. In this case, doctors recommend replacing the drug with a similar remedy.