The drug belongs to the group of myotropic antispasmodics and has a relaxing effect on the smooth muscles of internal organs and the vascular wall. Most people with hypertension are interested in the question: can Papaverine really lower blood pressure? The answer will be positive, this medicine can be used for hypertension for therapeutic purposes.
"Papaverine" is produced in several dosage forms:
- suppositories;
- tablets;
- injection.
The injection solution is dispensed from pharmacy points in glass ampoules of 2 milliliters in volume of ten pieces in cell packs. The composition of the drug includes one active substance - papaverine hydrochloride.
Healing properties
According to the instructions for use, Papaverine injections have a relaxing effect on the smooth muscles that are lined with internal organs. In addition, the drug affects the blood vessels, due to which injections somewhat reduce blood pressure.
"Papaverine" has a mild soothing effect. After applying the solution intramuscularly, the pharmacological effect appears after about half an hour and lasts up to six hours.
According to the instructions for use, pressure pills "Papaverine" have a pronounced antispasmodic and analgesic effect. With the help of a vasodilating effect, the medication can slightly affect the level of blood pressure.
Once in the general bloodstream, the active component of the drug inhibits the activity of the phosphodiesterase enzyme, which leads to a decrease in calcium in the body and disrupts the contractile function of smooth muscles, helping to relax them.
Papaverine perfectly neutralizes spasms of the intestines, as well as the uterus, gall bladder and bladder, respiratory organs, kidneys and blood vessels. In this case, the motor activity of relaxed muscles is fully preserved.
When papaverine injections are prescribed
Injections are prescribed to people in the presence of the following conditions and diseases:
- Angina pectoris (pain in the heart due to insufficient blood supply to the heart muscle).
- Exacerbation of cholecystitis (inflammation of the gallbladder - one of the most common complications of gallstone disease).
- Increased uterine tone in pregnant women.
- Renal or biliary colic (gallbladder inflammation is one of the most common complications of gallstone disease).
- Angiospasm (narrowing of blood vessels, small arteries and capillaries, resulting in impaired blood circulation and tissue fluid exchange).
- High temperature in adults and children.
- Colitis (an inflammatory disease of the colon mucosa).
- Cholangitis (inflammation of the bile ducts due to the penetration of infection from the gallbladder, intestines, blood vessels (more often) or along the lymphatic tract).
- Pylorospasm (a pathological condition manifested in childhood).
Indications for use of tablets
The drug is especially effective in the following cases:
- Gallbladder inflammation.
- Spasms of the smooth muscles of the gastrointestinal tract.
- As part of complex therapy for spastic colitis (inflammation of the mucous membrane of the large intestine, accompanied by insufficiency of peristalsis).
- Renal colic (an acute attack of pain in the lumbar region caused by a sharp violation of the outflow of urine from the kidney and impaired blood circulation in it).
- Increased uterine tone.
- Bronchospasm as part of a comprehensive treatment (a pathological condition that occurs when the smooth muscles of the bronchi are contracted and their lumen is reduced).
- Spasm of the blood vessels of the brain.
- Angina pectoris.
- Stroke (acute cerebrovascular accident leading to persistent focal lesion of the brain).
- A heart attack (a focus of ischemic necrosis of the heart muscle that develops as a result of an acute violation of coronary circulation).
- Pylorospasm (reduction of the pylorus (zone of transition of the stomach into the duodenum), which is observed mainly in infants, is due to functional disorders of the neuromuscular system of the pyloric part of the stomach).
Papaverine suppositories have the same indications for use.
Solution contraindications
Before you start using the drug, it is important to carefully read the annotation, since the Papaverine solution has a number of contraindications for use:
- Severe hypotension (lowering blood pressure by more than twenty percent of the original / normal values).
- Bradycardia (decreased heart rate).
- Individual intolerance.
- Severe liver and kidney disease.
- Children under six months of age.
It must be remembered that Papaverine cannot be used under reduced pressure. With extreme caution, it is necessary to use the injection solution for patients over sixty years of age, since the risk of hyperthermia is likely.
Restrictions on pills and suppositories
Medication in both forms of release is prohibited in the following cases:
- Children's age up to six months.
- A significant decrease in blood pressure.
- Individual intolerance to the drug.
- Acute renal or liver failure.
- Glaucoma (a large group of eye diseases characterized by a constant or periodic increase in intraocular pressure above tolerant).
- Coma (an acute developing severe pathological condition characterized by progressive inhibition of the central nervous system).
What pressure does Papaverine come from?
The medication acts on the internal organs, ensuring their relaxation. Due to the increase in clearance, the pressure in the capillaries becomes somewhat less, because the total capacity of arteries and veins increases.
The drug is not used with low blood pressure, as this will lead to an even greater hypotensive effect. Papaverine only affects smooth muscles and has absolutely no effect on striated muscles.
The drug does not affect the contractility of the heart or skeletal muscle. There is also no muscle relaxation, respectively, a feeling of weakness or other negative effects will not be manifested.
Use of the drug at high pressure
To reduce blood pressure, two medications are immediately administered to the patient intramuscularly - Papaverine and Dibazole pressure injection, this is done for maximum effectiveness.
Both drugs have a hypotensive effect. After administration of the drug, the patient's condition improves, unpleasant symptoms disappear, such as:
- headache;
- dizziness;
- weakness.
Blood pressure can decrease not only in patients who suffer from hypertension, but also in people undergoing stressful situations.
Tablets are used in a dosage of 40 to 60 milligrams two or three times a day, washed down with water. The introduction of intravenous and intramuscular Papaverine from pressure allows you to achieve the desired effect faster, so the dosage is reduced by 10 mg. The time interval between the procedures should be at least five hours.
As for suppositories, they should be introduced into the anus twice a day. After use, it is recommended to be horizontal for two hours so that the medicine does not leak out.
Side effects
The medicine "Papaverine" is well tolerated by people, but nevertheless, in rare situations, with increased sensitivity or overdosing, it can provoke the following unpleasant consequences:
- Dizziness.
- Intestinal obstruction (a syndrome characterized by a partial or complete violation of the movement of contents along the digestive tract and caused by a mechanical obstruction or impaired motor function of the intestine).
- Flatulence (a pathological condition of the body that occurs due to excessive gas formation and accumulation of gases in the gastrointestinal tract).
- Lethargy.
- Drowsiness.
- Decreased blood pressure.
- Hyperhidrosis (a disease in which excessive sweating occurs).
- Impaired liver function, as well as an increase in the activity of organ transaminases.
After stopping the use of the drug or lowering the dosage of "Papaverine" (it is often prescribed for pressure), all adverse reactions disappear.
With a strong excess of the recommended concentration of the drug, a person may experience a drop in pressure and the appearance of acute vascular insufficiency. In addition, the poisoning described above amplifies the negative effects described above.
Other drug compatibility
According to the instructions for use, Papaverine injections, as well as tablets and suppositories reduce the effectiveness of the following drugs - Methyldopa and Levodopa. Barbiturates significantly increase the antispasmodic effect.
An increase in the hypotensive effect is achieved with the use of tricyclic antidepressants:
- Quinidine.
- "Reserpine".
- Procainamide.
Papaverine lowers the pharmacological effect of Dopegit.
Features
You can not combine alcohol and therapy with this medication. Papaverine injections should be given with special care to people with low blood pressure, as well as to those who have recently suffered a head injury.
For persons with impaired functioning of the kidneys, as well as the liver and thyroid gland, it is important to consult a doctor before starting treatment.
Use of suppositories during pregnancy and lactation is prohibited, since there is no reliable information on the safety of Papaverine for the baby. The active component of suppositories can interact with drugs of other therapeutic groups, therefore, their possible use should be consulted with a medical specialist.
There is no reliable information regarding the effect of suppositories on the functional activity of the cerebral cortex, and therefore it is not recommended to carry out work involving the need for increased attention and speed of psychomotor reactions.
Generics
Papaverine has a number of substitute drugs to reduce pressure:
- "Band". In its structure there are two active substances - papaverine and dibazole in a ratio of one to one. The medicine helps expand the capillaries in the brain, which helps lower blood pressure and improve blood microcirculation.
- Andipal. This medication contains several active ingredients - papaverine, dibazole, phenobarbital and analgin. The drug is allowed to use hypertensive patients to reduce blood pressure and eliminate unpleasant symptoms.
- "Bioshpa" is used for spasms of smooth muscles, as well as headaches, high blood pressure. Adult patients can take orally from 50 to 60 milligrams three times a day, injections are allowed to be administered from one to two times a day, 60 mg.
- "No-Shpa" is used to neutralize spasms of various origins. It is often used during childbirth to relieve uterine spasm. Daily dosing is 130 grams, this concentration should be divided into two or three applications.
- Drotaverinum is widely used for spasm of smooth muscles, as well as colic, for a slight decrease in pressure. It is prescribed for use at 0.04 or 0.08 milligrams from one to three times a day.
Papaverine is usually used to relieve cramping and reduce blood pressure. It is necessary to observe the exact dosage, not exceeding it yourself in order to avoid poisoning. Patients who have an individual intolerance to the substances in the composition, you must refuse to use this medication.
How to store the drug
Papaverine in injections can be purchased at drugstores without a prescription from a medical specialist. Ampoules should be kept in a cool place. In case of violation of the integrity of the drug can not be used for injection. Candles and tablets have the same storage conditions as the injection.
Opinions
Reviews about "Papaverine" (it helps with pressure) can be found on various forums and online resources, since a wide range of therapeutic effects of the active substance helps to evaluate its effectiveness for a large audience of patients with various ailments.
Proctologists and their patients speak positively about the drug, since Papaverine is used as a complex conservative therapy for hemorrhoids.
The use of a medicinal product in the form of rectal suppositories helps to alleviate the bowel movement, partly helps to neutralize pain, as well as eliminate bleeding from dilated hemorrhoids.