Is a drug like Serrata effective? We will provide reviews about this medication in the materials of this article. You will also learn about how much the mentioned drug costs, how it should be used, whether it has contraindications and for which diseases it is prescribed to patients.
Composition, packaging, form
What substances are part of the drug in question? What does the instructions for use report about this? "Serrata" contains such an active element as serratiopeptidase. As additional substances, this drug includes sodium glycolate starch, light magnesium carbonate, lactose monohydrate, magnesium stearate, and corn starch.
The medication mentioned goes on sale in the form of tablets, which are coated with an enteric coating. They are placed in cell packages that are enclosed in cardboard boxes.
Pharmacological properties
What features are inherent in the mentioned drug? What does the instructions for use say about this? Serrata is an anti-inflammatory, decongestant, and fibrinolytic agent. What is the principle of its action?
Serratiopeptidase is a proteolytic enzyme that has been extracted from an intestinal bacterium of non-pathogenic nature (Serratia E15). The specified group of microorganisms quite quickly breaks down bradykinin and fibrin, as well as other inflammatory mediators. Moreover, it exhibits anti-inflammatory and decongestant function. This is due to the release of pain amines from inflamed tissues, which is characterized by an analgesic effect.
Instructions for use ("Serrata" is a universal medicine) reports that this medication is able to quickly penetrate into places that undergo an inflammatory process and lyse necrotic tissues and their decay products.
Also, the drug in question reduces hyperemia, catalyzes the absorption and activity of antibiotic agents. In addition, it lowers the viscosity of saliva and helps to thin the nasal secretions, facilitating their excretion.
Alpha-2-macroglobulins of blood and serratiopeptidase form an active complex in a 1: 1 ratio. This leads to a masking of antigenicity of enzymes without loss of their pharmacological activity. With the transition of the enzyme to the site of inflammation, as well as to exudate, the concentration of serratiopeptidase in the blood decreases.
Drug properties
Due to the breakdown of serotonin, histamine and bradykinin, serratiopeptidase reduces the dilatation of capillaries and reduces their permeability. It also contributes to the inhibition of plasmin blockers, improving their fibrinolytic activity.
After reducing microcirculation and eliminating puffiness, sputum is also successfully separated.
The active as well as additional substances of this drug are enclosed in an enteric coating. That is why the tablets "Serrata" are not destroyed in the stomach.
Pharmacokinetics
Where is Serrata absorbed? The instruction reports that the absorption process of this medication occurs in the intestine. In blood, its maximum content is detected after 60 minutes. A small amount of the drug is excreted with urine.
Indications for use
Due to its versatile effect, the drug "Serrata", the price of which is indicated below, is prescribed in the treatment of various diseases in completely different areas of medicine:
- In surgical practice and traumatology, this medication is used for fractures, dislocations, sprains and other injuries. In addition, it is often prescribed for edema, including postoperative. Also, tablets are taken by people in order to prevent probable transplant rejection.
- In otolaryngological practice, the drug "Serrata", reviews of which are positive, is prescribed for otitis media, sinusitis and other inflammatory processes (including VDF), which are manifested by difficult separation of sputum and increased mucus formation, as well as to improve the absorption of antibiotic agents.
- In plastic surgery, Serrata tablets are used to increase microcirculation in order to prevent probable transplant rejection, as well as to reduce swelling after the operation.
- In dermatology, this medication is recommended in the presence of acute dermatoses that occur with pain.
- In gynecology, the drug in question is used to eliminate swelling of the mammary glands due to various diseases. Also, this tool is prescribed for the accelerated process of resorption of hematomas, including with mastitis.
Contraindications
What contraindications do Serrata tablets have? The use of this medicine is prohibited:
- with hypersensitivity to serratiopeptidase, as well as other components of the medication;
- in pathological conditions that lead to an increased risk of bleeding or bleeding disorders.
Dosage and instructions for use
Serrata (tablets) is prescribed only inside. This drug should be taken in an amount of 30 mg per day, that is, 1 tablet three times.
Eating does not affect the absorption and effectiveness of the drug. The Serrata tablet must be swallowed whole. In no case should it be chewed, as this will damage its enteric membrane. Drink the medication with plain water.
Various types of disease, as well as their severity, require correction of the daily dose of the drug in one direction or another.
Only the attending doctor should select the minimum effective dose and determine the duration of its intake, based on the specific situation.
Side effects
What side effects can the Serrata medication cause? The instruction reports that when taking this drug in rare cases, there is a violation of the stool, pain in the digestive tract, nausea and vomiting.
People who are prone to bleeding may develop frequent nosebleeds and the appearance of blood in sputum.
In some cases, this drug can provoke allergic reactions, which manifest as itching or rashes on the skin, as well as urticaria.
Overdose of pills
Taking high doses of Serrata tablets can cause an increase in the above side effects, and in some cases even lead to the formation of internal bleeding. In this case, it is required to refuse to take the medication and conduct symptomatic therapy.
Drug interaction
With a combination of serratiopeptidase and anticoagulants, the effect of the latter is enhanced. If you need to take these drugs at the same time, the patient must be under the regular supervision of an experienced specialist who can adjust the dose of the anticoagulant.
Special recommendations
The drug in question has a direct effect on blood coagulation. Therefore, it should be used with extreme caution, especially when treated with anticoagulants, as well as with a person's predisposition to bleeding and clotting pathologies.
Particular care must be taken when prescribing serratiopeptidase to people with painful conditions of the kidneys and liver.
Reviews and price of the drug
How much is the drug "Serrata"? The price of this drug in the amount of 10 tablets is 100-120 rubles.
Reviews about this tool are more positive. Doctors say that this is a universal medicine that can be used in the treatment of inflammatory processes in surgery, traumatology, gynecology, etc.
Patients are satisfied with the results of therapy. They talk about the high effectiveness of this tool, especially when combined with antibiotics.