In this article, we consider the instructions for "Flemoklava Solutab."
It is difficult to imagine modern therapy of diseases of an infectious-inflammatory nature without the use of antibacterial agents. The most effective drugs against infections caused by bacteria are those created on the basis of amoxicycline. One of these drugs is the combined antibiotic Flemoklav. This medication is widespread, experts prescribe it for both adults and children. However, effective therapy is possible only if all the features of the drug are known.
The composition of the drug, pharmacological action
"Flemoklav Solutab" is a combined antibiotic, which consists of two main active ingredients - amoxicycline and clavulanic acid. Additional components that make up its composition contribute to more efficient absorption.
It has a fairly broad spectrum of action. Its amoxicycline inhibits the synthesis of bacterial cells, as a result, the reproduction of microorganisms having a pathogenic nature stops. Amoxicycline is effective against anaerobic bacteria (both gram-positive and gram-negative). Due to the presence of clavulanic acid in the composition, the effectiveness of the use of Flemoklav Solutab significantly increases.
Clavulanic acid is a metabolism that inhibits beta-lactamase - an enzyme that accumulates in the human body as a result of the reproduction and vital activity of bacterial cells. When clavulanic acid enters the body, bacteria enter the cell, destroys the enzymes that form inside. Thus, the bacterium loses beta-lactamase, which is required for its growth and development. As a result, the ability to develop resistance to amoxicycline is lost.
In addition, clavulanic acid itself is active against microbes. The beta-lactamase inhibitor allows you to inhibit the activity of enterococci, staphylococci, streptococci, enterobacteria, gonococci. According to the instructions for Flemoklav Solyutab 500 mg, with the combined use of clavulanic acid and amoxicycline, which are part of the product, the therapeutic effect sharply increases. This happens as a result of:
- Increased activity against bacteria.
- Extending the spectrum of action of the drug.
- Activation and strengthening of human antimicrobial immunity.
It should be noted that Flemoklav Solyutab is effective not only against bacteria producing beta-lactamase, but also against microorganisms that do not produce this enzyme.
Immediately after taking the medicine, the action of clavulanic acid orally begins - in an hour its maximum concentration is observed in the intestine, the concentration of amoxicycline reaches its maximum one and a half hours after administration.
Therapeutic concentrations of clavulanic acid and amoxicycline can be found in muscles, lung tissues, gall bladder, abdominal cavity, peritoneal and synovial fluids, nasal sinus secretion, bile, in the ovaries and uterus.
Release form
As the instructions indicate, Flemoklav Solutab is in the form of dispersible tablets. The dosage of the drug is indicated by the manufacturer on the package and reflects the content of amoxicycline and clavulanic acid itself. Each tablet has a special engraving that corresponds to a specific dosage of active substances.
- 500 mg of amoxycycline and 125 mg of clavulanic acid correspond to engraving 424.
- 250 mg of amoxycycline and 62.5 mg of clavulanic acid correspond to engraving 422.
- 125 mg of amoxycycline and 31.25 mg of clavulanic acid correspond to engraving 421.
- 875 mg of amoxycycline and 125 mg of clavulanic acid correspond to engraving 425.
The dispersible form of Flemoklava Solutab, unlike traditional tablets, promotes faster absorption of components in the stomach, and antibiotic release occurs only in the upper part of the small intestine. This form of the drug reduces the irritating effect of the components on the intestinal mucosa. As a result, therapy is better tolerated, there are no dyspeptic phenomena.
It should be noted that the composition of the drug does not contain allergenic substances, gluten, sugar, which allows it to be used in patients suffering from diabetes mellitus, celiac disease, gluten intolerance.
Is the use of Flemoklava Solyutab allowed for children?
Indications for use
This medication is an antibacterial antibiotic with a very wide spectrum of action. The effectiveness of the complex use of amoxicycline and clavulanic acid has been proven in therapy:
- Diseases of the upper respiratory tract caused by various infections. The medication can be used to treat sinusitis, tonsillitis, otitis media, pharyngitis. Flemoklav effectively suppresses various forms of angina (simple, lacunar, purulent).
- Inflammatory infectious diseases of the lower respiratory system, such as community-acquired pneumonia, bronchitis.
- Infectious diseases of the genitourinary system. With the help of Flemoklav, pyelonephritis, cystitis, urethritis, gynecological infections that are caused by microorganisms sensitive to amoxicycin are successfully treated. The medication can be used in the treatment of mild (uncomplicated) gonorrhea.
- Skin abscesses, erysipelas, furunculosis.
- Infectious diseases affecting the osteoarticular system, for example, osteomyelitis.
- Periodontitis, sinusitis and other dental diseases.
Side effects
According to the instructions and reviews to "Flemoklav Solyutab", there are no marked side effects. However, the drug can cause the following negative effects:
- Disorders of the digestive tract. Nausea and atibiotic-associated diarrhea may occur. The occurrence of diarrhea is caused by increased intestinal motility, which is typical for therapy with penicillin antibiotics. The work of the intestine is fully restored after the cancellation of Flemoclav or at the end of the course of treatment. With severe diarrhea, threatening dehydration, symptomatic treatment, for example, “Loperamide” is necessary.
- The development of candidiasis of the mucous membranes and skin (thrush). Though slightly, it violates the Flekoklav Solyutab microbiocenosis. The instruction contains information about this. Such conditions, in combination with undermined immunity, contribute to the beginning of enhanced reproduction of candida fungi. As a result, the corresponding symptoms appear. Women treated with Flemoklav are prone to vaginal candidiasis, candidiasis of the oral mucosa can occur regardless of gender.
- Dizziness and headache. Some of the patients noted sleep disorders, the appearance of irritability, in rare cases, convulsions.
- Allergic reactions. Most often, urticaria and itching occur, in rare cases, Quincke's edema, anaphylactic shock are noted.
- Changes in blood composition. The occurrence of leukopenia, thrombocytopenia, hemolytic anemia, thrombocytosis is not completely ruled out.
It should be remembered that taking the drug in strict accordance with the instructions in the instructions and the recommendations of the attending physician can reduce the risk of side effects by several times.
Contraindications
The instruction "Flemoklav Solyutab" is not recommended for use if:
- The patient has an individual intolerance to clavulanic acid, amoxicycline or antibiotics of the penicillin and cephalosporin groups, excipients.
- The patient suffers from infectious mononucleosis, lymphocytic leukemia.
- Severe liver damage was noted that occurred in the past as a result of taking this medication or its analogues.
- The patient has not reached the age of two years. This limitation is associated with the difficulty in choosing the right dosage. Flemoklav Solutab 875/125 mg can be prescribed for children over 12 years old.
It is allowed to use the drug with caution and under close supervision of the attending physician in the presence of severely occurring pathologies of the digestive system, liver or kidneys.
During pregnancy, the drug can be prescribed if there are strict indications for use. Despite the fact that there was no teratogenic effect of the drug, it is not worth using Flemoklav without special need. In the first trimester of pregnancy, a minimum dosage of a medication can be prescribed, which is drunk with a very short course. In the second and third trimesters, the drug is taken according to the instructions.
Amoxicycline and clavulanic acid do not penetrate into breast milk, therefore, during lactation, the drug is not contraindicated, moreover, you can not interrupt breastfeeding.
The instruction manual for Flemoklava Solutab is very detailed.
Drug dosage
In the treatment of adults, a standard dosage should be used. In the treatment of children, the dose is selected in accordance with the patient’s body weight.
Children who have reached 12 years of age and weighing more than 40 kg, as well as adults, are prescribed Flemoklav Solutab 500 mg three times a day. If the bacterial infection is severe, the dosage is increased to 875 mg, and the number of doses is reduced to two per day.
For children under 12 years of age and weighing less than 40 kg, the daily dosage should be calculated according to the following rule - for each kilogram of the patient's weight, 20 to 60 mg of amoxicycline should be taken. The resulting daily dosage must be divided into three doses.
If there are indications, the dose of the drug can be increased on the recommendation of a doctor, however, it should not exceed 60 mg of amoxicycline per day per kilogram of body weight.
If the patient has severe kidney damage, then when selecting the necessary dosage, the attending physician should take into account creatinine clearance. This will require an additional biochemical blood test.
The standard course of treatment is from 7 to 10 days, treatment with Flemoklav Solutab 500 mg according to the instructions for use should not be carried out for more than 14 days.
Take the tablet should be whole, or dissolved in water, before meals. This will reduce the risk of diarrhea and vomiting. To prepare the suspension, take no less than 30 ml of water. They drink it immediately, or during the day. When taking the pill entirely, it is washed down with plain water in the amount of one glass.
Treatment of children with this medication
Only a competent doctor is able to choose the right dosage of Flemoklav for the treatment of children. Most often, pediatricians adhere to the following dosage regimen:
- Children aged 2 to 7 years and weighing 13 to 25 kg are prescribed twice or thrice a day in a dosage of 125 mg Flemoklava Solutab. The instructions for use confirm this.
- Children aged 7 to 12 years and with a body weight of 25 to 37 kg are assigned a larger amount. Twice or thrice a day, 250 mg of Flemoklava Solutab according to the instructions for use.
It should be noted that children are more likely to drink a suspension prepared from a tablet. At the same time, it is absorbed faster. It is necessary to take before meals.
In the treatment of mild forms of diseases of the upper respiratory system, the course of treatment is 5 days. If the child has diarrhea, abdominal pain, severe dyspepsia, dehydration - you should inform the pediatrician who will cancel the drug.
Quite often, antibiotic therapy of children is carried out in combination with drugs saturated with beneficial bacteria. It can be Linex or Acipol. Such a comprehensive treatment avoids the development of dysbiosis and dyspeptic manifestations.
The instructions for “Flemoklava Solutab” must be carefully read.
Flemoklav and Flemoksin - which is better?
These drugs are analogues of each other, have an identical effect, are prescribed for the same diseases. Nevertheless, there is a difference between them, and it is determined by the entry of clavulanic acid into Flemoklav. Flemoxin does not contain this substance. Thanks to clavulanic acid, “Flemoklav” has several advantages over “Flemoxin” - its spectrum of action is wider, the required dosage is less, the effectiveness is higher.
However, the presence of clavulanic acid in Flemoklav's composition leads to the fact that this drug has a more extensive list of contraindications, and the risk of side effects is much higher.
The interaction of "Flemoklava" and alcohol
The instruction for this medication does not contain a strict ban on alcohol during the treatment period, but this does not mean that it is allowed to drink alcohol. This is due to the fact that alcohol increases the load on the kidneys and liver. As a result, the rate of assimilation and subsequent elimination of the antibiotic worsens. This provokes the occurrence of allergic reactions, dyspeptic manifestations. With the simultaneous administration of antibiotic and alcohol, the occurrence of nosebleeds and seizures is not ruled out. In this regard, doctors recommend that during the treatment period refrain from drinking alcohol-containing drinks.
So it is said in the instructions for use to "Flemoklav Solyutab."
Drug cost
The price of Flemoklav depends on the occurrence of the active substance. Packages with a dose of 125, 250 and 500 contain 20 tablets, in a package with a dose of 875 - 14 tablets.
Thus, the price of “Flemoklav” 250 mg ranges from 400-450 rubles, “Flemoklav” 125 mg - 300-350 rubles, “Flemoklav” 500 mg - 450-550 rubles, “Flemoklav” 875 - from 450 rubles.
Analogues of the drug
There are full analogues of Flemoklav, which contain amoxicycline and clavulanic acid, and incomplete - they lack the last ingredient. Such analogues are suitable for people with clavulanic acid intolerance.
Among the complete analogues, the most famous are:
- Amoxiclav - made in Switzerland.
- Ecoclav is a Russian drug, its cost is significantly lower than Flemoclav.
- "Amoxil" is a Ukrainian-made drug, it has a small number of contraindications.
- "Arlet" is a budgetary product of Russian production.
- Augmentin - British production. Available in the form of tablets for adults and in the form of a suspension for children.
- Verklab is a Russian drug, in the form of tablets and suspensions.
- "Medoklav" - is made in Cyprus. A distinctive feature is a pronounced therapeutic effect, effective after 2-3 days of administration.
Drug Reviews
What do people think about this medication?
Patients undergoing treatment using Flemoklava Solutab, in the reviews, note the high effectiveness of the drug in the fight against infectious diseases. Relief of the condition is observed after two days of taking the drug - the temperature decreases, the general condition of the body improves. Side effects are manifested mainly in the form of disorders of the gastrointestinal tract, which can be prevented by the simultaneous administration of Acipol or Linex. In addition, patients note a rather high price for the drug.
It should be remembered that treatment with Flemoklav should be started only after consultation with a specialist. Strict adherence to the doctor’s recommendations will avoid or prevent the occurrence of negative effects.
The article was presented to "Flemoklava Solyutab" instructions for use and reviews.