One of the tools widely used in modern medical practice at high blood pressure is Indapamide tablets. The instructions for use and reviews of doctors prescribing the drug, and patients taking it, indicate that the tool is effective and efficient. It belongs to the group of diuretic drugs. Use "Indapamide" can only be prescribed by a doctor. Self-medication with this remedy can easily provoke negative consequences.
Pharmacology
According to the instructions for use and reviews by cardiologists, Indapamide is an effective drug for the treatment of hypertension. Doctors who use the medication in their practice, note that the drug is reliable, affordable, therefore, it is applicable for the treatment of people of various categories and groups. "Indapamide" is effective not only with high blood pressure, but also with chronic insufficiency of the heart, if this condition is accompanied by accumulation of water, sodium retention in the body - the diuretic corrects such effects, facilitating the patient's condition.
In the instructions for use of "Indapamide" (1.5 mg and other dosages), the manufacturer indicates that the drug belongs to the group of thiazide diuretics. The tool reduces the tone of the smooth muscles of the arterial muscles. A moderate saluretic effect is inherent in it, since under the influence of the active compound the processes of re-absorption of sodium ions, chlorine, and liquid in the Henle loop are inhibited.
The decrease in OPSS observed with the use of Indapamide 1.5 mg (the instructions must be carefully observed!) And other release options is explained by a decrease in the susceptibility of the vessel wall to the second angiotensin, norepinephrine. The production of prostaglandins is activated, the activity of calcium ions entering the smooth muscle fibers of the vessel walls decreases. Studies have shown that the use of Indapamide in reasonable doses does not correct the fat profile, does not affect the metabolism of carbohydrates.
Technical points
In the instructions for use of the tablets “Indapamide”, the manufacturer indicates that the pressure decreases only in a state where the patient's initial indicators are above normal. A stable result can be observed by the seventh day of treatment with a medication. Maximum efficiency is achieved on average by the end of the first quarter of the year. This applies only to situations where the patient uses the drug systematically.
Shortly after ingestion, as the manufacturer indicates in the instructions for use of "Indapamide" 2.5 mg and other options for release, absorption is observed. The process is fast, characterized by increased efficiency, so that the degree of absorption is close to 100%. The absorption processes are localized in the stomach, intestinal tract. In blood serum, the maximum concentration of the active ingredient is achievable in an hour or two after taking the pill. With plasma proteins, approximately 79% of the substance enters into stable bonds. The distribution of the body is quite wide. There is no cumulative effect.
The manufacturer notes in the instructions for use of “Indapamide” 2.5 mg, 1.5 mg: the half-life is on average 18 hours. Elimination is mainly carried out by the kidneys, the main percentage is excreted as processed products. Approximately 5% of the received dose of indapamide leaves the body unchanged.
What's on sale?
On the pharmacy shelves you can see "Indapamide" in a dosage of 1.5 and 2.5 mg of active substance in each tablet. The drug was named after the active compound contained in it - it is indapamide.
Each dose of the drug contains not only the main substance, but also a number of auxiliary substances. Their list is necessarily listed in the instructions for use with the tablets. Indapamide contains aerosil and cellulose, starch and lactose, macrogol. In the manufacture of tablets used titanium dioxide, magnesium compounds, hypromellose. It is especially important to familiarize yourself with this list in detail for people suffering from intolerance to any compounds (for example, lactose).
One cardboard box contains 10-30 tablets of Indapamide. Instructions for use accompanying the drug, reveals the nuances of taking the medicine, possible side effects, indications for use.
Is there anything else?
You can find Indapamide capsules on sale. They contain the same active substance, as well as a number of additional components. A complete list is indicated in the accompanying documentation. One package contains 10-30 capsules.
Another form of release is Indapamide powder. Instructions for use with it contain a description of the rules for taking the drug. One cardboard box contains one bottle of powder.
Mutual influence
The effectiveness of the tool can be judged by numerous responses, since many who accept the composition leave positive feedback about it. Instructions for use "Indapamide" 2.5 mg, 1.5 mg recommends combining the drug with other antihypertensive drugs. In this case, it is necessary to control the balance of electrolytes in the circulatory system.
If Indapamide and hormonal anti-inflammatory are used at the same time, it is possible to decrease the effectiveness of the effect on pressure, since water and sodium ions accumulate in the patient’s body - this effect is inherent in GCS. A similar interaction is observed with the systemic use of drugs containing tetracosactide.
When combined with non-hormonal anti-inflammatory in forms that have a systemic effect, there is also a risk of reducing the effectiveness of the agent in question. If the patient's body loses excess moisture excessively, kidney function in the acute form may be insufficient, since glomerular filtration is weakened.
Note!
In the instructions for use of Indapamide, the manufacturer indicates that the combination of the drug with ACE inhibitors can provoke a lack of sodium in the body.
The combination with calcium preparations can lead to excessive accumulation of this substance in the circulatory system, since urine removes calcium less productively than in a healthy person.
Combination with cardiac glycosides can cause a lack of potassium in the body. A similar effect is sometimes observed when combining Indapamide and corticosteroids.
Judging by the reviews, "Indapamide" (instructions for use confirms this) can cause an undesirable effect if you use the drug simultaneously with laxatives. In laboratory studies, it is usually found that the deterioration of health is due to a decrease in the concentration of potassium in the body. A similar effect is possible when Indapamide and mineralocorticoids, glucocorticoids, tetracosactide are ingested.
Safety Above All
As consumers note in their reviews, the instructions for using Indapamide are clear and understandable, so it’s not difficult to understand the limitations indicated here. In particular, the manufacturer notes that the combination of the drug with baclofen can lead to a significant decrease in blood pressure. The combination with tricyclic antidepressants also enhances the hypotensive effect of indapamide. With such drug therapy, the likelihood of orthostatic hypotension becomes higher.
If you use "Indapamide" in combination with erythromycin intravenously, vincamine, halofantrine, sotalol and some other substances, the likelihood of arrhythmia increases. A complete list of combinations that can lead to such an undesirable effect is indicated in the instructions for the specific form of release.
"Indapamide" and preparations containing lithium, in combination, can lead to an increased toxic effect of lithium, since the clearance in the kidneys decreases. Combination with metformin can lead to acidosis. Presumably, this is due to functional insufficiency of the kidneys, which is associated with the peculiarities of the influence of diuretic drugs on the human body.
Too much!
The manufacturer does not indicate in the instructions for use at which pressure Indapamide should be used - it is only mentioned here that the drug is intended for the treatment of hypertension. The choice of boundaries at which it is already necessary to use tablets, the definition of a treatment program and its features is the care of a qualified specialist. Improper use at its discretion can easily lead to an overdose. This condition is expressed by nausea and vomiting. The patient has a disturbed stool and a balance of water and electrolytes in the blood, and the pressure decreases. Possible weakening of the functionality of the respiratory system.
Excessive consumption of Indapamide against cirrhosis can cause coma in this organ.
If an overdose is detected, it is necessary to rinse the stomach and take funds that correct the content of electrolytes in the blood, water. If the condition requires this, the doctor selects drugs to correct specific symptoms. Indapamide has no antidote.
Is it worth taking?
You can find a lot of positive feedback about the drug from people who followed the doctor’s recommendations and instructions for use. Reviews about "Indapamide" 1.5 mg, 2.5 mg indicate that it is an effective tool. True, this only applies to situations where the drug is used in accordance with the manufacturer's recommendations and under the supervision of a doctor in charge. Persons who have been prescribed a medication by a professional acknowledge that continued use of Indapamide allows you to take pressure indicators under control and significantly improve your condition.
It is necessary to study the instructions for use of "Indapamide" before taking the drug. At what pressure the drug is used, the manufacturer does not indicate here, explaining this by the fact that the medication is intended for course administration. "Indapamide" is not an instant drug for a one-time pressure reduction - its effectiveness is observed with prolonged use in accordance with the program developed by the doctor.
From the reviews it is clear that the negative consequences of taking to a greater extent were experienced by persons who used the medication at their discretion.
Are there any analogues?
The instructions for use of "Indapamide" indicate that the main active component of the drug is indapamide. The following drugs are based on it:
In many ways, the instructions for using Indapamide and analogues are similar. Means are designed to correct high blood pressure, belong to the group of thiazide diuretics, so you need to use them in approximately the same conditions.
According to reviews, analogues of "Indapamide", the instructions for use of which contain an indication of a similar active component of drugs, are much more expensive than the described tool. If for pharmacies Indapamide is now asking for 20 rubles or more, Ravel SR will cost 170 rubles, and Arifon more than 300 rubles.
If it is impossible to purchase the drug recommended by the doctor, you need to seek help from a specialist. The attending physician will tell you which option is better to use as an alternative to Indapamide in a particular case.
How to use?
The dosage in the instructions for use of "Indapamide" is indicated taking into account some features of the patient's condition. The drug is intended to be taken once a day, preferably in the morning. As a rule, Indapamide is prescribed in an amount of 2.5 mg. If the effectiveness of the drug is too small, after two weeks of constant administration, you can double the volume, and after a couple of weeks to bring up to 7.5 mg.
It is allowed to take no more than 10 mg per day. If it is necessary to use such large volumes of the drug, the dose is divided into two portions, both are used until lunch.
Strongly impossible!
"Indapamide" is prohibited if there is a violation of blood flow in the brain tissue. It is not allowed to take the drug with severe violations of the liver and kidneys. "Indapamide" is prohibited for people suffering from severe diabetes mellitus, as well as gout during an exacerbation.
You can not use the drug if hypersensitivity, immunity of any substance present in the composition of the tablets is established.
Kinetics Features
Soon after the intake of Indapamide tablets, the drug is rapidly absorbed. The process proceeds somewhat slower if you use the medicine during the meal. Bioavailability is estimated at 93%. The quality of the absorption process does not depend on the use of tablets during meals or outside meals.
With the systematic use of the drug, changes in the concentration of the active substance in the blood serum are reduced. One week after the start of the course, an equilibrium plasma concentration can be observed.
The active substance of the drug is able to form strong bonds with elastin present in smooth muscle vascular fibers.
It was revealed that "Indapamide" penetrates the blood-brain, placental barriers. The substance is found in milk of nursing mothers.
The metabolic processes are localized in the liver.
You can, but carefully!
It is allowed to use "Indapamide" if violations of the functionality of the liver, kidneys, as well as the balance of electrolytes and fluids are detected, if those are assessed as not too strong. The described tablets can be used with the possibility of constant monitoring of the patient's condition, if an extension of the QT period is established, hyperparathyroidism is detected.
If possible, monitor vital indicators Indapamide is used against the background of the use of arrhythmias. It can be used by patients with diabetes mellitus if the disease is currently in the decompensation stage, but only if it is possible to constantly monitor the dynamics of vital indicators. A similar condition applies to the use of Indapamide for hyperuricemia.
Course Features
If "Indapamide" in the amount of one tablet containing 2.5 mg of the active substance does not show a pronounced effect, do not immediately increase the dosage. If after four weeks the patient’s condition has still not improved, it will be reasonable to first combine Indapamide with other substances against pressure that do not belong to the diuretic class.
If it is necessary to use "Indapamide" in combination with other means of pressure from the very beginning of the therapeutic program, the medication is used in the amount of 2.5 mg, is used as food in the morning, and plenty of clean water is used without additives.
Negative consequences: what to prepare for?
Tests have shown that the use of Indapamide in systemic lupus erythematosus can trigger an exacerbation. Also, when using the drug there is a risk of leuko-, thrombocytopenia, anemia, bone marrow aplasia. Some patients develop agranulocytosis. The use of the drug is associated with the likelihood of an allergic reaction. As a rule, this manifests itself on the skin with itchy areas, rashes. Possible vasculitis, urticaria.
Patients taking Indapamide are more likely to become infected with the urinary system. There is a risk of polyuria. More likely inflammation of the ENT organs. Sometimes pills provoke a cough.
"Indapamide" can cause nausea and vomiting, weight loss. Some patients note that while taking the drug it hurts and dizzy, dries in the mouth, stomach ache, and stool is broken. There is a risk of liver encephalopathy and pancreatitis, asthenia and increased fatigue. "Indapamide" can provoke a nervous and anxious state, craving for sleep, impaired ability to maintain balance. In some patients, sleep is disturbed, the condition worsens, the psycho-emotional status is inhibited. There is a risk of muscle cramps, tension, anxiety. Patients can be irritable when using Indapamide tablets.
Special occasion
"Indapamide" can be used in combination with cardiac glycosides only when it is possible to control creatinine clearance, the content of potassium ions in the circulatory system. Similar conditions apply to those suffering from hyperaldosteronism, forced to use laxatives. Particularly noteworthy are the elderly.
Using Indapamide tablets, it is important to regularly take tests to check the content of potassium ions in the circulatory system, as well as to clarify the concentration of magnesium and sodium in the blood serum.The use of a diuretic can cause an imbalance in the electrolytes. To ensure safety, patients taking Indapamide are advised to regularly check the acidity of the blood, the content of uric acid, glucose, and nitrogen fractions in it.
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