Itomed is a drug that affects the digestive tract. The drug improves the motility and tone of the digestive tract. The medication has a pronounced antiemetic effect.
The components of the drug, release form
The drug is made on the basis of itopride, is available in the form of tablets. The dosage of the active substance in one tablet is 50 mg. Tablets can be purchased in packs of 40 and 100 pcs. Auxiliary components are anhydrous silicic acid , hypromellose, lactose, macrogol 6000, corn starch, magnesium stearate, carnauba wax, titanium dioxide and carmellose. In cases when Itomed does not suit a person, similar drugs are selected by a specialist, but with a different composition.
Pharmacological action, pharmacokinetics
The medicine belongs to antacid enveloping agents. The drug also has an antiulcer effect, does not change the level of gastrin. Increased gastrointestinal motility occurs due to antagonism with D2-dopamine receptors and inhibition of acetylcholinesterase.
The medication promotes the release of acetylcholine, protects it from destruction. An antiemetic effect develops as a result of interaction with D2-dopamine receptors that are located in the trigger zone.
After using the tablets, a dose-dependent suppression of vomiting is achieved, the appearance of which is provoked by Apomorphine.
The use of the drug has a positive effect on the work of the upper gastrointestinal tract, thanks to the use of this drug, transit through the stomach is accelerated, and the process of emptying is being established. The analogues used instead of Itomed have a similar effect.
The absorption of the drug in the digestive tract occurs quickly, bioavailability is approximately 60%. In order for the concentration of the drug in the blood to become maximum, it takes from 30 to 45 minutes. The accumulation of funds in the body is minimal. Communication with proteins: with albumin - 96%, with alpha-acid glycoprotein - about 15%.
The medication is well distributed in the tissues, it enters the small intestine, stomach, adrenal glands, liver, and kidneys. Itomed is found in breast milk, a small amount is found in the spinal cord and brain. Metabolic processes occur in the liver, the drug is excreted by the kidneys, partial excretion occurs within six hours, with trimethylaminuria longer.
Indications, contraindications
Itomed, analogues are prescribed when it is necessary to treat non-ulcer dyspepsia, which is accompanied by chronic gastritis. The drug is indicated for bloating, the presence of nausea with the development of vomiting, with heartburn and pain in the stomach. If patients have discomfort in the abdomen, especially in the epigastric region, Itomed is also prescribed, its purpose is also possible with anorexia.
Tablets are not taken with hypersensitivity to their components, with bleeding in the intestines and stomach. Contraindications also include glucose-galactose malabsorption, lactose intolerance, lack of lactase. It is forbidden to use the drug for children under the age of sixteen, pregnant and lactating women. Analogs of Itomed can be selected with perforation of the digestive tract and mechanical obstruction.
Special treatment conditions are required for patients who take m-cholinomimetics and cholinesterase inhibitors, elderly patients with impaired renal and hepatic function.
Drug use, dosage
The medicine is taken daily before eating food at a dose of 150 mg, that is, three tablets are needed, 50 mg at a time. Elderly people reduce the dose of the drug. In cases where it was not possible to drink the pill on time, further use of the drug should be performed at regular intervals. Do not double the dose.
Side effects
Side effects may occur after taking Itomed. The analogue instruction recommends prescribing if this medicine does not fit the patient. Adverse reactions can develop from the digestive, nervous and endocrine systems. Some patients develop allergic reactions, laboratory indicators temporarily change. Possible disturbances in the functioning of the immune system and reproductive. Metabolic processes may be disturbed and skin lesions may occur. Side effects also include changes in the hematopoiesis system.
Overdose is eliminated by gastric lavage and the implementation of symptomatic therapy. In such cases, to continue treatment, analogues can be prescribed instead of Itomed.
special instructions
If the patient has signs of gynecomastia and galactorrhea, the therapy is temporarily stopped or transferred to another drug. The use of Itomed in the treatment of biliary cirrhosis (primary) can lead to transient decompensation of cirrhosis, this condition disappears on its own after drug withdrawal. It is worth temporarily abandoning the implementation of important tasks that require increased attention and quick psychomotor reactions during the treatment with Itomed. Analogs, substitutes are selected together with a specialist, if necessary.
Itomed leads to faster absorption of other drugs. The effect of using the medicine does not worsen as a result of taking drugs whose action is aimed at reducing the acidity of gastric juice. The effect is less pronounced with the simultaneous use of the drug with m-cholinergic blockers, with the combination of the drug with cholinesterase inhibitors, m-cholinomimetics, the effect of taking Itomed tablets is more pronounced. Analogs can manifest themselves differently in such cases.
Analogs, reviews
When you need to replace the drug, this issue is discussed with a specialist. Often, doctors prescribe Itoprid as a substitute and carry out treatment using Itopra or Ganaton. These analogues of Itomed incorporate the same active substance.
Domestic substitutes are also available. There are analogues for Itomed, Russia (Russia), such as Tseruglan, Gastrika-GF.
Despite the fact that Itomed has been treating patients for a long time, there are few reviews of its use. Usually, taking the drug for six to eight weeks leads to the elimination of flatulence, reduces the manifestation of heartburn, leads to the disappearance of heaviness in the stomach and the appearance of appetite. Patients consider the drug effective for chronic constipation. Reviews reflect good tolerance to the drug and the absence of serious side effects. Most often, diarrhea develops, there is a headache and pain in the abdomen. Reviews show that the drug can lead to the development of amenorrhea. However, everything is individual and the action of Itomed may differ, so that there are no serious consequences, treatment should be prescribed by a doctor.