"Clotrimazole" is an antifungal drug. The drug has antibacterial, anti-amoebic and anti-trichomonas action. The active component destroys the cell membranes, as a result of which pathogenic microorganisms die. The spectrum of action of this tool is quite wide. The drug "Clotrimazole" is able to eliminate the causative agents of almost all diseases of bacterial and fungal etiology. The medication is suitable both for independent use, and for use in combination, it is also used for preventive purposes. If necessary, you can pick up analogues of "Clotrimazole".
Composition, release form
There are several dosage forms. The drug is made in the form of vaginal suppositories and tablets. Means for external use are produced - gel, cream, ointment, solution with an active substance concentration of clotrimazole 1%. Candles and tablets contain 100 mg of the main component, tablets can also contain 500 mg of clotrimazole.
Of the excipients, nipagin, tween-80 are present in the composition. Auxiliary effect is glycerol, petroleum jelly. Additionally, cetyl alcohol was used , distilled water.
Pharmacodynamics
Clotrimazole acts by inhibiting the synthesis of ergosterol, which is necessary for the formation of the cell membrane of microorganisms. As a result, its permeability worsens, cell lysis occurs. This drug and Clotrimazole analogues contribute to the improved permeability of the phospholipid membrane that liposomes possess and the vacuolization of the cytoplasm. In addition, there is a decrease in the number of ribosomes. The drug inhibits the activity of peroxidases, which affects the process of destruction of cells of pathogenic microorganisms. In the cells, hydrogen peroxide accumulates better, so the causative agents of the disease are destroyed more efficiently.
Using "Clotrimazole", it is possible to cure erythrasma and diseases caused by trichomonads, staphylococci, yeast, dermatophytes.
Pharmacokinetics
The absorption of the drug is negligible and corresponds to 3-10% of the dose used. The drug does not penetrate the body through the mucous membranes and the skin.
Indications
Consider cases where it allows you to assign "Clotrimazole" instructions for use. Analogs can be used to treat the same diseases. The drug is indicated for the detection of such diseases:
- mycosis, the course of which is complicated by secondary pyoderma;
- erythrasma;
- pityriasis versicolor;
- superficial candidiasis, the causative agents of which are fungi, dermatophytes and microorganisms that are sensitive to clotrimazole;
- mycoses, in which the feet, folds of the skin are affected;
- fungal skin diseases.
"Clotrimazole" (ointment), analogues of this form of the drug are used to treat mycoses, the development of which was provoked by mold fungi, blastomycetes and dermatomycetes. Ointment is used to treat dermatomycosis, to which a secondary infection has joined.
Contraindications
Using this medication does not treat diseases that developed in women during the first trimester of pregnancy. Contraindication to the use of the drug is hypersensitivity to its components. Regarding treatment with “Clotrimazole” during menstruation - it is not produced at this time. You can use the medicine while breastfeeding, but with caution.
Drug use, dosage
"Clotrimazole" (cream), analogues are used in diseased areas that have previously been cleaned and dried. The product is applied to the skin thinly, then gently rubbed. The procedure should be performed two or three times a day. To cleanse the skin, it is recommended to use soap whose pH is neutral. The duration of therapy is determined by the severity of the condition, the location of the lesion, the effectiveness of the treatment.
Usually, at least a month is required to eliminate dermatomycosis, pityriasis versicolor can be eliminated in 1-3 weeks. Fungal lesions of the legs are treated even after the disappearance of the signs that accompanied the disease, it is additionally required to lubricate the skin for at least another half month.
"Clotrimazole" tablets, their analogues are used for six days. In the evening of each day, one tablet of the product is placed deep in the vagina. If there is such a need, another one is administered in the morning. The duration of treatment can be increased to twelve days. The most effective option is the simultaneous use of ointments and tablets. It is possible to repeat the course of treatment after it is prescribed by a doctor. For easier administration, the pill should lie on your back or bend your knees slightly.
Candida balanitis and vulvitis are treated with cream, applying it to the affected areas daily two or three times. The duration of the course is at least six days, usually no more than twelve.
"Clotrimazole" -candles, their analogues are prescribed for both women and girls. Their use is possible after the onset of sexual activity. Candles are placed deep in the vagina in the evening. For easy administration, you can lie on your back or bend your legs. It is necessary to be treated for six days. Continue therapy only after receiving the appropriate recommendations of a doctor.
Preparations in the form of a gel, ointment, cream are applied in a small layer, gently rubbed. The procedure is repeated several times a day (2 or 3). The skin should be cleaned with a neutral pH and dried.
Like medicines of other forms, the solution is also applied with a thin layer in the morning and evening, rub well. It is necessary to use a few drops of the drug. The solution is suitable for the treatment of adult patients and children. It is necessary to process both the affected area and the adjacent areas. After the acute symptoms have disappeared, treatment is carried out for about another month.
If the feet are affected by dermatomycosis, the medicine after eliminating the symptoms, use another half a month. You must use the solution after each procedure of washing your feet.
Side effects
The original drug, analogues of "Clotrimazole" can cause side effects. Puffiness, blisters in the places of application of the drug are rarely found, peeling and skin irritation occur. Urticaria, burning, itching, and erythema may occur.
special instructions
The possibility of prescribing the drug to a pregnant or lactating woman should be determined by the doctor, taking into account many factors.
If the patient has problems with the liver - liver failure, it is necessary to regularly check its function.
When using the drug, avoid applying it to the area near the eyes.
The drug can be used to treat onychomycosis with short cropped nails, so the drug penetrates better into the affected area. In such cases, it is better to use the solution, it provides better penetration.
The appearance of hypersensitivity to the drug is an occasion to discontinue the drug. The absence of the desired effect within a month requires confirmation of the diagnosis.
In order to prevent re-infection, the implementation of therapy is indicated for both a woman and a man. For the effective elimination of trichomoniasis, combined treatment is necessary in combination with drugs that have a systemic effect.
If necessary, combine the drug with other means, you should consult your doctor and follow his recommendations.
The cost of the drug, reviews, analogues
If you want to replace "Clotrimazole", analogues and prices will help to make the right choice. The same active substance contains "Faktodin", "Lotrimin", "Gine-Lotrimin." Kanesten, Antifungol, Clotrimazole-Acre belong to the analogues in structure. The same active substance is composed of "Yenamazole", "Amiklon." Clotrimazole is based on the action of the Kanizon and Imidil preparations. As a substitute, the doctor may prescribe “Candizol”, “Candibene”. Treatment using Candida is possible.
A solution (15 ml) can be purchased for 120-140 rubles, ointment (20 g) for 36-89 rubles, gel (20 g) for about 23 rubles, cream (20 g) for 37-155 rubles . The cost of tablets (6 pcs. 100 mg) is 15-55 rubles.
The original drug, analogues of “Clotrimazole” do not help everyone, sometimes there are side effects such as burning, itching. Some women have a blood discharge. Many people like the price, in most cases the drug is effective, and there are no discomfort during treatment with its use. For the most effective treatment, you can use the drug only after prescribing by a doctor and in accordance with his recommendations.