In the article, we will consider instructions and reviews for Candibene candles. This is a drug with an antifungal effect, which is part of the group of imidazole derivatives and demonstrates fungicidal and antibacterial activity. The drug is available in various forms, including ointment, solution and suppositories in the form of vaginal tablets, which will be discussed below.
Structure
Clotrimazole acts as an active component in the drug. This substance is an effective antifungal agent. Tablets for intravaginal administration are also available under such trade names as "Imidil", "Amiklon", "Fungicide" and "Kandin". Candibene suppositories in the form of vaginal tablets may contain 100 or 200 mg of clotrimazole. Packed tablets in cells of three in one box. The packaging is equipped with a special applicator for the correct insertion of the tablet into the vagina.
In addition to clotrimazole, the composition of “Candibene” is supplemented with such auxiliary components as:
- Lactose Monohydrate.
- Adipic acid.
- Corn starch.
- Sodium bicarbonate.
- Magnesium stearate.
- Copovidone.
- Polysorbate.
- Anhydrous colloidal silicon.
The tablets themselves are painfully colored oblong, biconvex.
The properties
Candibene suppositories as an antibacterial and antifungal agent have a wide range of effects on pathogenic microflora. The antimycotic property of the drug is due to the ability of clotrimazole to disrupt the natural production of ergosterol, which is part of the membrane of the fungal cell. In addition, clotrimazole reduces the intensity of the production of certain enzymes that cause the accumulation of pathogenic fungi in healthy cells.
In small quantities, Candibene is able to suspend and even completely stop the reproduction of harmful fungal cells. In high doses, clotrimazole demonstrates its good fungicidal properties, affecting fungal spores and the cellular structure of microorganisms. In addition, the active component interacts with enzymes inside the cells. Against the background of its activity, the level of concentration of hydrogen peroxide increases to such an extent that the fungus is destroyed.
Candibene suppositories are active in relation to such fungi that cause dermatophytosis, as well as yeast-like and moldy varieties, color lichen and erythma pathogens. The antibacterial effect is in relation to both gram-negative and gram-positive microorganisms. The drug also effectively destroys the vaginal trichomonads.
According to the instructions for Candibene suppositories, the absorption of the drug by the mucous membranes when using vaginal tablets occurs slowly and in small quantities, so the medication does not have a systemic effect on the body. The maximum concentration of clotrimazole is observed in the deep layers of the epidermis.
With intravaginal use of tablets, 3-10% of the drug enters the systemic circulation. In the vaginal secretion, the drug persists for 2-3 days. Candibene is metabolized by the liver and excreted as inactive substances.
Indications
Candibene suppositories are used to treat various fungal infections of the female reproductive system. The drug is prescribed to eliminate dermatophyte, yeast and mold fungi, as well as for the treatment of candidiasis.
In addition, indications for the use of tablets are:
- Vulvovaginal candidiasis.
- Trichomoniasis
- Superinfection of the genitals.
- Remediation of the birth canal.
Contraindications
The drug is considered relatively safe, therefore, it has no contraindications, except for hypersensitivity to the components included in the composition of vaginal tablets.
Many women are interested in the possibility of using "Candibene" during pregnancy. Data from clinical studies have shown that the drug does not have a teratogenic effect, as well as a negative effect on the condition of a woman during gestation. However, doctors warn women against using pills in the first trimester. Next, determine the feasibility of using vaginal tablets should be the attending physician. Reviews about Candiben candles during pregnancy will be presented below.
When using tablets, clotrimazole does not penetrate into breast milk, therefore this form of the drug is not prohibited during the lactation period, in contrast to similar local drugs. It is not recommended to use vaginal tablets against the background of menstrual bleeding. The therapy should be carried out immediately before the onset of menstruation or the treatment should be postponed to another time when the menstruation is over. Also, during therapeutic measures, it is not recommended to use hygienic tampons.
Instruction manual
Vaginal tablets should be administered before going to bed. The drug is inserted deep into the vagina, one tablet at a dosage of 100 mg per day for six days or at a dosage of 200 mg for three days. In some cases, the doctor may prescribe a second course of treatment for Candibene.
Intravaginal tablets are administered using a special applicator, which is included with the drug. Use the pill most optimally while lying on your back. In this case, the following sequence of actions is recommended:
- Remove the tablet from the cell and insert into the applicator.
- Insert the applicator deep into the vagina. After smoothly pressing the applicator, the tablet takes the necessary position in the vagina.
- After the procedure, the applicator must be thoroughly washed with warm water.
- For the rehabilitation of the birth canal, a single use of the Kandibene tablet is recommended.
It should be remembered that during pregnancy, the use of an applicator is not recommended.
Adverse reactions
When using vaginal tablets, the following adverse reactions are most often observed:
- Local allergic reactions to clotrimazole, accompanied by itching, burning and dermatitis.
- Vaginal discharge, severe burning.
- Frequent urination.
- A complicated form of cystitis.
- Soreness during intercourse.
- Pain in the abdomen.
- Burning in the penis of a partner.
- Headache.
Overdose
If the dosage prescribed by the doctor is exceeded, conditions that are hazardous to human life or health are not created. However, if you accidentally swallow a vaginal tablet, the following signs of intoxication may develop:
- Nausea and vomiting.
- Anorexia.
- Gastralgia.
- Pathological changes in the liver.
- Drowsiness.
- Dermatological reactions in the form of rash and redness.
- Frequent urination.
Clotrimazole does not have a specific antidote, therefore, in case of an overdose, the stomach is washed and enterosorbents are taken, as well as symptomatic treatment.
Special recommendations for use
What else does the “Candibene” candle application manual tell us? The therapeutic regimen for trichomoniasis involves the combination of clotrimazole with metronidazole. If not only the labia, but also the areas of the skin adjacent to them have been infected, along with suppositories, “Candibene” cream is also used. In this case, if there is an increased sensitivity to the components of the drug, its use should be discontinued.
If, after the prescribed course, there is no positive dynamics in the patient’s condition, you should consult a doctor who will select another drug, having previously prescribed an additional examination. To prevent relapse, you need to undergo treatment with a sexual partner. Candibene is rarely prescribed in combination with other drugs in the form of suppositories. With liver failure, it is important to monitor the state of the organ during treatment with the drug.
Analogues of candles "Candibene"
On the basis of clotrimazole, quite a lot of drugs are produced not only in Russia but also in India. The most common analogues are:
- Amiklon.
- Akriderm.
- "Clotrimazole-Acre."
- Candide.
- Klomegel.
- "Candizol."
- Candiderm.
Replacing the drug with an analogue requires the advice of a doctor, since each drug composition has its own contraindications, dosages and application features.
Candiben Candlelight Reviews
Experts say that Kandibene is an effective and effective drug. Using suppositories is a simple and convenient way to get rid of fungal lesions in the female reproductive system.
Patients are also satisfied with the results of therapy. Women with the help of vaginal tablets quickly get rid of the unpleasant manifestations of candidiasis and trichomoniasis. Some patients complain of allergic local reactions when using the drug, but this is due to an individual reaction to clotrimazole. Pregnant women respond positively about this medication. Candles are completely safe, the main thing is not to use them in the first trimester and clearly follow the instructions.
In any case, before you start using suppositories, you should consult your doctor, since Candibene has a number of restrictions for use and can only be used when pathogens are sensitive to clotrimazole.
We reviewed the instructions, testimony, and reviews of Candibena.