The drug “Mexidol” (reviews note that the medication helps relieve nervous tension, remove headaches and lower cholesterol) is a modern antioxidant. It is used to stimulate cerebral circulation, a positive effect on memory. The body after treatment with Mexidol becomes more resistant to oxygen deficiency. Used to treat adults, seniors and children. It was created in 1996 by scientists from Russia. It is widely used in medical practice for the treatment of vascular diseases.
The composition of the drug
In reviews of Mexidol, patients note that the drug improves blood supply to the cerebral cortex. It acts quickly and efficiently.
Mexidol Injection Solution is in the form of a colorless liquid with a yellowish tinge. The active component of this medication is ethylmethylhydroxypyridine succinate. Excipients are sodium metabisulfite and purified water.
Pharmacology
Reviews about "Mexidol" are positive, people call it "a real savior." They say that it alleviates the condition of vegetovascular dystonia, relieves vascular spasm. Improvements occur after the first injection.
The drug is characterized by nootropic, antihypoxic and anxiolytic properties. It has a membrane protective and anticonvulsant effect. Makes the body more resistant to stressful situations and the influence of negative factors. Helps to transfer oxygen deficiency arising under conditions such as:
- hypoxia;
- intoxication of the body;
- shock;
- coronary heart disease;
- cerebrovascular accident.
Mexidol has a beneficial effect on brain metabolism. It improves blood supply to the brain, stimulates microcirculation, reduces platelet aggregation, positively affects blood properties, normalizes the plasma structure during hemolysis, and stabilizes platelet and red blood cell counts.
The medicine lowers cholesterol, as well as low density lipoproteins. It has lipid-lowering quality. Reduces the degree of intoxication that occurs with pancreatitis in the acute stage of development.
Mexidol increases the amount of dopamine found in the brain. It enhances the activity of glycolysis and reduces the inhibition of oxidative reactions that occur during hypoxia in the Krebs cycle. At the same time, the content of creatine phosphate and ATP increases. There is a stimulation of mitochondrial functions and normalization of cell membranes, metabolic processes in the myocardium are stabilized, and the necrosis zone is reduced. Electrical activity is restored, myocardial contractility improves, coronary blood flow to the ischemic zone enters in a larger volume. The consequences that appear with reperfusion syndrome, coronary insufficiency, become less pronounced. Antianginal activity of nitro drugs increases.
The drug protects against damage to the optic nerve fiber, as well as retinal ganglion cells with neuropathy, and helps to increase visual acuity.
Indications for use
In the reviews on the use of Mexidol, it is noted that the drug is often prescribed by neurologists for children with speech delay. They say that the medicine works effectively, and the child becomes calmer after therapy, starts talking and better assimilates new information.
Mexidol is prescribed for cerebrovascular problems. The drug is used for traumatic brain injuries and to eliminate the consequences after them. Indications are vegetovascular dystonia and dyscirculatory encephalopathy. Assign a solution for injection in atherosclerotic cognitive disorders occurring in the mild stage of development. Use it for anxiety. Involved in the treatment of myocardial infarction, open-angle glaucoma and in inflammatory, purulent processes in the abdominal cavity (peritonitis, pancreatitis).
The drug is indicated for alcoholism, when there are vegetovascular and neurotic disorders. The medicine relieves withdrawal symptoms in alcohol dependence. Intoxication of the body with various antipsychotic drugs is the reason for the appointment of this drug.
The price of Mexidol in reviews (analogues can replace this medicine if necessary, but they must be selected by a doctor) is indicated as overpriced, because the drug is Russian and could cost several times cheaper.
Contraindications
More than once, the good prophylactic effect of thrombosis was confirmed by patients in reviews of Mexidol. Analogues, despite the content of succinic acid and lower cost, are inferior to this tool in their effectiveness. Therefore, doctors use “Mexidol” in their practice and do not recommend replacing it with other medicines.
The drug has contraindications. It is not used in case of impaired renal and hepatic organ. It is not used for hypersensitivity to the active component and excipients of Mexidol.
Caution should be exercised when treating pregnant and lactating women, as well as children, with this medication, due to the lack of clinical trials.
"Mexidol": instructions for use
In the reviews (the price of the injection solution is 500 rubles for 10 ampoules of 2 ml each), patients say that they were satisfied with Mexidol, which was used to treat cardiovascular diseases.
The Mexidol solution is administered intramuscularly and intravenously. The introduction of the drug is made as a stream, and drip. If the drug is administered by infusion, the drug is diluted with sodium chloride.
The jet injection of the drug should be slow, for 5-7 minutes. The drip rate is 40-60 drops per minute. The daily maximum rate is 1200 mg.
In case of circulatory disturbance in the brain, Mexidol treatment is carried out for 10-14 days, drip. At a dosage of 200-500 ml from two to four times a day. In the future, the drug is administered to the patient for another two weeks, but already intramuscularly. 200-500 ml from two to three times a day.
Treatment of traumatic brain injury lasts 10-15 days. The drug is used dropwise, up to four times a day, at a dose of 200-500 mg.
With a diagnosis of discirculatory encephalopathy (therapy is carried out at the stage of decompensation), Mexidol is prescribed intravenously, 1-2 times a day. A single dosage is 200-500 mg. Thus, the treatment is carried out for two weeks. In the next fourteen days, the drug is administered intramuscularly once or twice a day. For the course prevention of the occurrence of discirculatory encephalopathy, the medication is used for two weeks, twice a day, 200-250 mg. The drug is administered intramuscularly.
Cognitive impairment in the mild stage in people aged, as well as anxiety, are treated with intramuscular injection of Mexidol, in an amount of 100 to 300 mg / day. Therapeutic course 2 to 4 weeks.
With myocardial infarction, Mexidol is used in complex therapy. Assign both intramuscularly and intravenously. The course of treatment is two weeks. Doctors recommend putting the medicine intravenously for five days, and administering the remaining nine days intramuscularly.
Intravenous administration is done only through a drip infusion. Slow. The drug is diluted with sodium chloride 0.9%. Dilution of the drug with glucose is allowed. Mexidol is administered to patients in a dosage of 100-150 ml for about 0.5-1.5 hours. Allowed jet injection, lasting at least five minutes.
With a heart attack, the drug is administered three times a day, every eight hours. The daily dosage is 6-9 mg. This amount is calculated per kilogram of patient weight. A single norm of 2-3 mg per kilogram of body weight. The daily dose is 800 mg, no more than 250 mg is recommended at a time.
"Mexidol" with open-angle glaucoma is used only in complex therapy. It is administered intramuscularly, up to three times a day. The daily dosage is 100-300 mg. The duration of therapy is two weeks.
In the treatment of withdrawal symptoms resulting from alcoholism, the medicine is used intravenously and intramuscularly. The daily dose is 200-500 mg. The course of treatment is seven days.
For drug intoxication, Mexidol is administered intravenously. The daily norm is 200-500 mg. The duration of therapy is 1-2 weeks.
With purulent-inflammatory processes taking place in the abdominal cavity, the drug is prescribed on the first day before surgery. Subsequently, it is administered to the patient throughout the postoperative period. Dosage depends on the severity and form of the disease. Cancel Mexidol gradually.
Instructions for the use of Mexidol warns of strict adherence to the rules for taking the medicine. The price (in the reviews, some people claim that the medicine helps with stress and depression, positively affects the quality of sleep), the drug is fully justified by its effectiveness.
special instructions
The reviews on the use of Mexidol indicate good tolerability of this drug. Accept the host that it has virtually no contraindications. It is noted that the drug completely eliminates headaches with vegetovascular dystonia.
The drug increases the effect of benzodiazepine anxiolytics on the body. Enhances the effect of anticonvulsant drugs, especially carbamazepine. Similarly, Mexidol acts on antiparkinsonian drugs. It also reduces the toxicity of ethyl alcohol.
Instructions for use warns of side effects during treatment with Mexidol. In the reviews, some individuals claim that they did not see any effect from the use of this drug and say that the drug did not improve their condition in cardiovascular diseases.
In people with bronchial asthma who have a special sensitivity to sulfites, the drug can provoke the occurrence of negative symptoms of hypersensitivity.
Among the adverse reactions of the use of "Mexidol" was noted:
- nausea;
- allergic reactions;
- dry mouth
- the appearance of drowsiness.
If negative symptoms appear, consult a doctor and cancel the drug.
Mexidol: analogues
The reviews (the instructions describe in detail the features of the use of the drug and should be studied before using the medication) contain information that the drug is not suitable for everyone, and therefore it is important that the doctor prescribes it. Self-medication should be completely ruled out.
If Mexidol did not work for treatment, then it can always be replaced by analogues, this:
- Neurox
- Mexicor;
- "Cerecard";
- Astrox
- Mexiprim;
- Mexifin;
- "Mexidol Pharmasoft."
When choosing analogues, do not forget to consult a doctor in order to avoid side effects.
Based on the reviews on the use of Mexidol, consumers consider the price of analogues of the drug more affordable.
Release form, cost
Mexidol for injection is in the form of a solution intended for intravenous and intramuscular administration. The drug is enclosed in glass ampoules with a break point. There are three marking rings on the ampoules. The top is yellow, the middle is white, and the bottom ring is red.
Ampoules are produced in volumes of 2 and 5 ml. Five pieces are enclosed in cell blisters. One or two blisters with Mexidol ampoules and instructions for use can be in a cardboard box.
Price (in reviews, analogues are not considered the best option for the treatment of vegetative-vascular dystonia and those who have undergone treatment are advised not to replace Mexidol with them) the medication fluctuates around 500 rubles for 5 ampoules of 5 ml each. 10 ampoules of 2 ml are the same.
Patient Reviews
In psychoneurological, cardiological and ophthalmological practice, Mexidol has found its application. In the reviews, the price of the drug is indicated as overpriced. They say that treatment is expensive, especially if the medicine must be used for a long period.
People note that the drug in ampoules is more effective than in tablets. In addition, patients say that they are often prescribed the drug for vegetative-vascular dystonia. In this case, it lowers cholesterol well. Relieves headaches, chills, tremors of limbs and dizziness.
The drug showed itself well in stress and depression. Removes panic attacks. Clarifies the head and improves memory. Against this background, people's perception of the world is changing. They become calmer and more self-confident. Stop being afraid of others.
According to patients, the drug is often prescribed in the treatment of cardiovascular diseases, in combination with other drugs. The medicine well strengthens blood vessels and improves blood circulation. Relieves cramps, numbness of limbs. Stabilizes sleep.
The drug is prescribed for diseases of the visual apparatus, to activate blood circulation in the eyeball. According to patients, it increases visual acuity, gives clarity to the eyes. In order to avoid side effects, experts advise reading the instructions before treatment.
There are negative reviews about Mexidol. They compare the drug with a dummy and say that it does not help with vegetovascular dystonia and cardiovascular diseases. In some, the drug intensified the symptoms of the disease. Panic attacks became more pronounced, anxiety, distraction and headache appeared.
Some believe that Mexidol gives only a temporary effect, and negative symptoms, after its cancellation, return.
Negative opinions about the drug are much less than positive. The majority of people were satisfied with the treatment.
Doctors reviews
Mexidol Injection Solution (Pharmasoft) is widely used by doctors in their practice. They find the drug effective. They say that he successfully treats cardiovascular pathologies. It gives a good and lasting result in the treatment of traumatic brain injuries. He proved himself worthy in the treatment of anxiety, emotional lability, encephalopathy and asthenia. Very often it is used for acute cerebrovascular accident.
The positive aspects of the medication of the doctor include the fact that patients of various age categories can use it. Doctors note a wide range of uses of the drug. Some doctors combine an injection with a tablet. Injections are used at the very beginning of therapy, and the results are fixed by tablets.
Specialists noted side effects that occur during treatment with Mexidol. This is heaviness in the head, dry mouth, nausea, increased and jumps in blood pressure, weakness.
Some doctors consider the drug ineffective. They say that it gives a short-term result and is little studied.