In the article, we will consider the instructions and reviews for the Neotigazone preparation.
It is a drug from the retinoid category for the treatment of psoriasis and other chronic skin pathologies. The effectiveness of this medication is quite high. He has no cheap substitutes. This drug is produced in Europe, its cost is very high and in Russia ranges from one to three and a half thousand rubles, depending on the dosage of the drug.
Reviews about Neotigazone abound.
Basic information about the drug
The causes of psoriasis are not yet fully understood, and at this stage the main goal of therapy is to eliminate the symptoms and return the patient’s skin to its original, and at the same time, healthy appearance.
Some doctors are of the opinion that psoriasis is recommended to be treated only by applying external ointments to the damaged area of the skin, but most specialists are inclined to the need for complex therapy, and the drug “Neotigazone” is included in the list of basic appointments. This medicine is a synthetic vitamin preparation. It is important to know that it is used only in case of a severe course of the disease and it is required to take it only after the appointment of a doctor. According to reviews, Neotigazone helps with psoriasis very well.
Doctors say that the best effect of therapy is achieved only if the patient uses this medication strictly according to the schedule prescribed by the doctor and does not change it to substitutes without prior consultation.
The composition of the medication
The main component of this medication is a substance called acitretin, which is a synthetic analogue of vitamin A. It took a lot of time for pharmacists to get this component. The main difficulty was that it was simply impossible to isolate vitamin A in an artificial form that would not have a toxic effect on the human body due to hypervitaminosis. Side effects from such therapy were too serious, in this regard, obtaining the optimal formula of acitretin is considered a breakthrough in the treatment of psoriasis. Synthetic vitamin A, being part of this medication, has regulatory functions. It also has the following properties:
- Normalization of the process of formation of new skin cells.
- Stabilization of metabolic processes.
- The provision of immunomodulatory effects.
- Removal of inflammation.
Taking the medicine also entails a number of some consequences, but against the background of the fact that acitretin leaves the body quite quickly, they are easily tolerated and inconsequential.
Reviews on the use of Neotigazone are mostly positive.
Facts about the drug
In relation to the drug in question, some facts can be given:
- The medicine "Neotigazone" is a medicine from the group of retinoids. Its active substance is acitretin, which acts as an analogue of retinoic acid (that is, vitamin A).
- The effects of this drug are to normalize the processes of proliferation of skin cells, and in addition, to stabilize their keratinization. In the presence of psoriasis and other hyperkeratoses, these processes can just be disturbed.
- The mechanism of action of acitretin on skin cells is not yet fully understood.
- The withdrawal period of this drug from the human body is usually fifty hours. As for complete elimination, it usually takes about thirty days.
- Retinoids, especially neotigazone, produce a teratogenic effect, causing congenital malformation in the fetus during pregnancy of a woman who was taking this medication.
It should be noted that when drinking alcohol simultaneously with the Neotigazone preparation, etretinate can form in the body, which is completely excreted from the body only after two years. It follows that for two years after a combination of taking the drug with alcohol, in no case should you become pregnant.
Indications for drug treatment
This medical product is suitable for use if the patient has the following pathologies:
- Psoriasis, especially severe forms of the disease.
- Lichen planus, especially its hypertrophic form.
- Ichthyosis.
- Daria’s disease.
Instructions for use "Neotigazone"
The medicine can be purchased at the pharmacy only with a prescription, which should be prescribed by a dermatologist. Self-administration of this drug is strictly contraindicated.
According to the instructions, the doctor is obliged to tell the patient, especially if it is a woman who is of childbearing age, about the dangers of the appearance of deformity in the fetus. Thus, within two years it is undesirable to become pregnant in order to avoid such consequences.
Treatment with retinoids and acitretin in general cannot be carried out alone, that is, as part of monotherapy. It is imperative to undertake a set of treatment methods, one of which is this drug.
Features of the use of the drug for psoriasis
The considered drug Neotigazone is considered very effective against such a pathology as psoriasis, which is confirmed by doctors with patients. Laboratory studies demonstrate that a significant improvement in the condition of the skin is usually observed in forty-seven percent of cases. Twelve percent of patients completely relieve the symptoms of psoriasis.
The initial norm of this medication is one capsule with a dosage of 25 milligrams of the active ingredient. It is worth recalling that this drug alone does not produce the desired effect. Psoriasis therapy should be comprehensive.
In order for the active component of the drug to help as much as possible, take it while eating. Also, you can take after eating. Doctors strictly warn their patients that during treatment it is required to abandon the use of alcoholic beverages. This is due to the following reasons:
- The substance acitretin can react with ethyl alcohol, because of this dangerous toxic substances can form in the body.
- Alcohol causes an additional load on the liver, which negatively affects the well-being of patients.
The dosage of the drug is prescribed by the attending physician, choosing it based on the individual characteristics of the patient. In this case, the specialist assesses the severity of the course of psoriasis along with other features of the body. Independent change in dosage can cause extremely serious consequences.
It is important to note that in case of an overdose of Neotigazone, patients may experience symptoms of excess vitamin A in the body. This is often accompanied by dizziness and migraine.
The duration of Neotigazone therapy may vary. Usually, this drug is taken until the symptoms of psoriasis have completely disappeared, and after that continued long-term maintenance therapy with small doses is continued.
Patients taking Neotigazone cannot act as blood donors for a year after therapy.
How should I take this medicine for lichen planus?
The initial norm is one capsule with a dosage of 25 milligrams of the active ingredient. Maintenance dosage is less than 20 milligrams per day (i.e. one, maximum two capsules). In rare cases of severe lesions with a large mass, a dosage of 50 milligrams per day is prescribed.
Is it possible to drink Neotigazone for children and pregnant women?
This is allowed, but only in cases of ineffectiveness of other methods of treatment. The daily dosage in this situation is 0.5 milligrams per kilogram of body weight of the child.
It should be noted that this medication is categorically not suitable for treatment for lactating or pregnant patients.
This is stated in the instructions for use with Neotigazone. We will consider reviews below.
Is it possible to use alcohol during the treatment with this agent?
The answer in this case is also negative. But in particular, a categorical ban on the use of alcohol is imposed on women who are of childbearing age. The reasons for this have been described above. Answering the question of whether there is a teratogenic effect in patients receiving men, the answer will also be negative.
Side effects
Reviews of Neotigazone confirm that the drug can provoke the following side effects:
- The appearance of a teratogenic effect, that is, the occurrence of malformations in the bearing fetus.
- Against the background of large dosages and with prolonged use, symptoms of vitamin A hypervitaminosis may occur. In this case, patients often have dry skin along with headache, nausea, vomiting, dry lips and jaundice.
- An increase in liver aminotransferases, and in addition, alkaline phosphatase. In this regard, it is required at least once a month to take blood tests for a functional liver test.
In general, according to reviews, "Neotigazone" from psoriasis is well tolerated by people. In case of adverse reactions, it is enough just to cancel this medication, and everything will definitely pass.
Contraindications to the use of the drug
Contraindications include the following conditions and pathologies:
- The period of pregnancy and lactation.
- The presence of individual intolerance to the main components of the drug.
- You can not use this medicine at the same time as vitamin products containing vitamin A.
- The presence of liver and kidney failure.
Analogs of this drug
As analogues of Neotigazone, you can consider drugs such as Isotretinoin along with Sotret or Roaccutane. It is worth noting that absolutely all systemic retinoids in pills or capsules are expensive drugs, so at present there are simply no cheap substitutes for the medication.
Neotigazone reviews
According to the reviews of doctors and patients, we can confidently say that the effectiveness of the considered medical device is quite high. People taking this medicine note a regression of the clinical manifestations of the disease. In addition, in reviews of Neotigazone, it is noted that psoriatic plaques disappear along with papules of flat red lichen due to its administration, and itching decreases. Relapses appear very rarely. But this requires mandatory comprehensive treatment.
Thus, the drug “Neotigazone” acts as an effective medicine that fights the symptoms of psoriasis. But it is worth noting that he can not cope with the causes of the disease. That is why the percentage of the problem returning is so high.
This medicine is mainly used to treat men, since women are afraid of the harmful effects of this drug on the reproductive system. In general, reviews often report that after treatment with Neotigazone, psoriasis disappears from absolutely all parts of the body.