Cirrhosis is a severe damage to the liver, which is characterized by the gradual replacement of its functional cells, as well as hepatocytes, by fibrous tissue cells. As the number of liver parenchyma cells decreases, it becomes more difficult for the body to cope with its main responsibilities - lipid metabolism and cleansing the body of toxins. Therefore, a patient who suffers from cirrhosis acquires an icteric complexion and large-scale disturbances in the functioning of the digestive system. What medicine to take with cirrhosis of the liver? Let's consider further.
With severe liver damage, the shape, density and internal structure of the organ changes. The fibrous tissue penetrates and compresses it, and the surviving parenchyma cells multiply increased, trying to compensate for the deficiency. Subsequently, the liver becomes small, as well as hard and bumpy, but this is not the worst. The random growth of parenchyma cells often leads to changes in the genotype of their cell structure, and then they transform into tumor cells.
There are several types of liver cirrhosis, which depend on the causes of the disease:
Viral (exacerbation of viral hepatitis).
Congestive cirrhosis is caused by difficulty in the outflow of venous blood from the liver due to chronic heart disease.
Biliary (associated with a mechanical obstacle to the movement of bile).
Alcoholic cirrhosis is considered the result of long abuse of "strong" drinks.
Toxic (occurs under the influence of the drug, or poisons that destroy the liver). Medicines that cause liver cirrhosis should be stopped at the very first symptoms of the disease.
Idiopathic cirrhosis is so called because it has no clear reason.
What medications are used for cirrhosis? This will be discussed later.
Hepatoprotectors
Hepatoprotectors are drugs that have a protective effect on hepatocytes. This group includes a large number of medicines, the effectiveness of the main part of which has not been proven by clinical trials.
In Russian pharmacology, approximately seven hundred hepatoprotectors have been recorded, which belong to sixteen subgroups, depending on the active component. But not all of them are relevant when it comes to serious degenerative lesions of the liver.
Essential phospholipids
Complex fats, the structure of which is formed by fatty acids, phosphoric acid, and sometimes also nitrogen atoms.
In the hematopoietic system, there is a constant metabolism of esters of polyhydric alcohols between plasma and red blood cells. This process helps to keep non-polar fats in dissolved form and distribute them throughout the body. Thus, without essential phospholipids, an exact balance of carbohydrates, as well as fats and cholesterol, would not be possible. What medications for liver cirrhosis are best taken (from the group of essential phospholipids)?
"Essential Forte N"
The phospholipids included in the structure of the drug are endogenous in chemical composition, but with a higher concentration of polyunsaturated fatty acids in them surpass them in activity.
After the incorporation of these molecules into the damaged sections of the membranes of the liver cells, the integrity of the hepatocytes resumes, which helps to regenerate them. Due to the geometric isomerism of their polyunsaturated fatty acids, the parallel arrangement of alkanes in complex fat cells ceases.
The phospholipid structure of hepatocytes is thus "loosened." This leads to an increase in their elasticity and fluidity, which leads to an improvement in metabolism.
The resulting functional blocks enhance the activity of enzymes, which, in turn, helps to improve the physiological pathways of metabolic processes. The hepatoprotector transfers cholesterol and neutral fats to oxidation sites and regulates lipoprotein metabolism. This process occurs due to an increase in the ability of high density lipoproteins to bind to cholesterol.
As a result, "Essential Forte N" leads to a stable state of protein and lipid metabolism, detoxification effect of the liver. It also accumulates and regenerates the cellular structure of the liver and phospholipid-dependent enzyme systems. In the end, this contributes to the natural regeneration of cells and prevents the formation of connective tissue. Country of origin - Germany.
Essliver Forte
Essential fatty acids provide a lipid-lowering, hepatoprotective and hypoglycemic effect. Essliver forte is an Indian medicine for cirrhosis.
Considered to be complex components that are diglyceride esters of linoleic and oleic unsaturated fatty acids, phospholipids regulate the permeability and activity of membrane-bound enzymes. They normalize the metabolism and processes of oxidative phosphorylation in case of hepatocyte disorders.
Thus, using the Indian medicine for liver cirrhosis "Essliver forte", you can restore cell membranes. Integrating into biological membranes, unsaturated fatty acids take on the harmful effects of the environment, protecting the lipids of the diseased organ.
The medication brings the liver function to a stable state and, according to the reviews on the drug, enhances its detoxification effects.
"Phosphogliv"
A complex preparation with a membrane-stabilizing, hepatoprotective and antiviral effect.
Indications for use:
- Alcoholic, medicinal, toxic liver disorders.
- Hepatosis (that is, a group of diseases based on metabolic disorders in the liver cells and the development of dystrophic changes in them).
- Cirrhosis of the liver.
- Acute and chronic viral hepatitis.
- Psoriasis.
- Intoxication (negative general reaction of the body to the intake of toxins).
- Neurodermatitis (a chronic skin disease of a neurogenic-allergic type, occurring with periods of remission and exacerbation).
"Phosphogliv" is an effective medicine for cirrhosis. Country of origin - Russia.
"Phosphoncial"
This drug is considered a complex medication. The drug is used to treat diseases of the liver and bile ducts.
"Phosphoncial" is a hepatoprotector that acts as follows:
- Activates the production of protein.
- It normalizes the metabolism of phospholipids, proteins and lipids.
- Helps to improve the functional state of the liver and enhance its detoxifying effect.
- He takes an active part in the activation and protection of phospholipid-dependent enzyme systems.
- Helps preserve liver cells and helps restore their damaged structure.
- Prevents the formation of connective tissue in the liver.
- It has a choleretic effect in the presence of cholestasis.
Country of origin - Russia.
Natural drugs for the treatment of liver cirrhosis
The main active ingredient that suppresses the harmful effects is milk thistle extract. It is this plant that is most rich in silymarin, a component that, like a barrier, builds protection around hepatocytes and blocks them from damage.
A direct analogue of silymarin is cynarin, which has a similar hepatoprotective effect. This substance is concentrated in large quantities in the seeds of artichoke.
Hepatoprotectors of animal origin
This group of drugs for the treatment of cirrhosis includes sublimated substances and products of hydrolytic breakdown of proteins of the liver of pigs and cattle. It is believed that drugs for cirrhosis of the liver and hepatitis of animal origin help to compensate for the lack of own cells in a diseased human organ. But the mechanism of this compensation looks very controversial, and the effectiveness of drugs has not yet been proven by clinical studies.
In addition, sublimated hepatic substances and hydrolysates are considered powerful antigens that provoke allergic reactions and serious side effects in people sensitive to them. Therefore, the decision on the appointment of such drugs should be made only by a specialist after a thorough examination of the patient and weighing the possible benefits and risks. Such drugs that protect the liver are dispensed strictly according to the doctor’s prescription.
Herbal medicines
The main substance of the medicine of this group is milk thistle. It is part of the structure of the drugs described below. In addition to a useful plant, they are saturated with auxiliary components that have a positive effect on the functioning of the organ:
- "Carsil."
- "Allohol."
- Gepabene.
- Sibektan.
- Bongjigar
- Galstena.
- Dipana
"Allohol"
This medicine has an activating effect, which helps to strengthen and accelerate the excretion of bile from the body. Due to the active ingredients included in the structure of the drug, intestinal function improves, which helps to prevent obstruction and the occurrence of putrefactive processes. "Allohol" stabilizes the process of bile formation, as well as contractile capabilities of the gall bladder, and, accordingly, the work of the liver.
Improving the functioning of the gallbladder and liver helps to normalize the secretory capabilities of the pancreas and duodenum.
Subsequently, which beneficial microelements are absorbed from the products absolutely completely, flatulence and a feeling of heaviness in the intestine are eliminated. Correct bile secretion under the influence of tablets has a small antispasmodic effect, which leads to the elimination of pain in the abdomen and right hypochondrium, as well as nausea and a taste of bitterness in the oral cavity.
Improving the excretion of bile reflexively increases the secretory activity of other digestive organs. Subsequently, a large number of pancreatic juice with digestive enzymes is thrown out, which enhances the absorption of food, eliminates rotting and fermentation in the intestine. Improves digestion, and also helps eliminate flatulence and constipation. Constant elimination of bile also has an antispasmodic effect, eliminates pain. "Allohol" is the best medicine for cirrhosis caused by alcohol. Country of origin - Ukraine.
Karsil
Hepatoprotective drug, the structure of which includes dried extract of the fruit of milk thistle, which is considered a substitute for silymarin. This is one of the newest cure for liver cirrhosis.
The drug is used for various impaired functioning and liver diseases, as well as for preventive purposes.
Under the influence of the drug, the structure of the liver cells is restored. When using "Karsila", toxins are eliminated from the body and metabolic processes come back to normal, due to which the patient's well-being improves.
The drug has an antioxidant effect on the body, enhances blood flow to the tissues and cells of the liver. People who constantly paid attention to nausea, bitterness in the oral cavity, heaviness in the right hypochondrium and suffered from loss of appetite, noted an improvement in their general condition. Country of origin - Bulgaria.
Gepabene
Gepabene is the latest cure for cirrhosis. This drug of natural origin is complex. The extract of the smoky officinalis, which is part of the structure of the drug, contains fumarin. This is an alkaloid that has a choleretic effect.
In addition, fumarine helps to stabilize the formation of bile and has a cholespasmolytic effect - it reduces the tone of the sphincter, which improves the flow of bile into the duodenum.
Alkaloid fumarin eliminates spasms of the gallbladder and bile ducts and stabilizes the amount of bile produced, which facilitates its delivery to the intestine. The composition of the drug includes silymarin, which has a hepatoprotective effect. The drug is effective in acute and chronic intoxication of the body, characterized by disruption of the sodium ion channels. It has antioxidant activity, which binds toxins and free radicals in the tissues of the liver, increases the process of combining protein, and helps restore liver cells. The medicine improves the functioning of this organ in various pathologies that occur in a chronic form.
Most doctors, as a rule, leave positive comments about “Hepaben”, since it has long been used to eliminate liver and gall bladder diseases, while giving good results. Although some experts doubt the effectiveness of this drug.
Patients also respond well to the medication. It is extremely rare to mention side effects, for example, such as:
- diarrhea (a pathological condition in which the patient has frequent bowel movements, while the stool becomes watery);
- weakness;
- heaviness in the right hypochondrium.
It is recommended to use this medication only as prescribed by the doctor, who will make sure that it is correctly prescribed and that there are no prohibitions on the use. This is one of the best cure for liver cirrhosis. Germany is a manufacturer of the drug.
Vitamin and mineral complexes for the liver
The body of a patient suffering from cirrhosis of the liver, is in great need of vitamins. The most important among them are retinol, ascorbic acid, tocopherol and lipoic acid. In addition, vitamins are necessary to maintain the normal functioning of intracellular chemical reactions in the liver:
- thiamine;
- riboflavin;
- a nicotinic acid;
- adermin;
- folic acid;
- cobalamin;
- routine.
The disease provokes functional malfunctions in the digestive organs, one of the results of which is the insufficient absorption of fat-soluble vitamins in the intestine. These include cholecalciferol and antihemorrhagic substance. Therefore, the doctor, as an adjunct treatment, can prescribe vitamins to the patient.
Diuretic drugs for cirrhosis
Opinions that diuretics are recommended for use only in the active phase of decompensated liver cirrhosis, which is accompanied by ascites, are incorrect. As a rule, it is best to prescribe diuretic drugs for prevention immediately after the transition of the disease to the active stage, since the development of abdominal dropsy in such people is almost inevitable, it is only a matter of time.
Even at the first stage of inflammatory liver disease, stagnation appears: venous blood block occurs, and, as a result, increased lymph production. This process, in turn, leads to a decrease in the pressure of the ionized gas and a decrease in the volume of blood circulation. The body tries to fix the problem by sending signals to the adrenal glands to produce more aldosterone hormone.
Too much aldosterone causes the fluid to constantly accumulate and persist. This causes swelling of the legs, arms and internal organs. To prevent edema from passing into abdominal dropsy, a patient with cirrhosis should follow a diet, monitor daily diuresis and start using diuretic drugs with the first symptoms of edema.