The drug "Folliculin" belongs to the category of hormones and their substitutes. It is widely used to treat insufficient ovarian function. This remedy is a natural ovarian hormone (follicular hormone).
1 milliliter of the drug contains estrone (active substance) and peach oil.
According to the instructions to "Folliculin," this estrogenic drug stimulates the development of sexual characteristics, and in addition, the uterus with their underdevelopment. Estron is produced in the ovaries after puberty, which continues until the menopause. It acts as a natural follicular hormone that regulates the normal development of the reproductive system in women.
The medicine manifests a specific estrogenic effect, which consists in stimulating the proliferation of the endometrium (in the tubes, vagina, cervix, genitals, mammary glands and excretory ducts). Taking the drug promotes the development of the uterus and female sexual characteristics in case of their underdevelopment, eliminating or reducing the severity of the violation that occurs in the female body due to insufficient functions of the sex glands during the menopause or after the gynecological operation.
Along with progesterone, it is involved in the regulation of the menstrual cycle and the function of procreation. In small doses, the secretion of follicle-stimulating hormone is activated. In case of taking large doses, it inhibits it, retaining water and sodium ions in the female body and suppressing erythropoiesis.
Hypocholesterolemic effect
The drug may exhibit hypocholesterolemic effects, improving glucose utilization and increasing the sensitivity of peripheral tissue to insulin. This agent is fairly well absorbed. Its large plasma level can persist for four to five days.
The drug is metabolized mainly in the liver (the process can partially take place in the lungs, adipose tissues), is excreted together with bile. Then it is reabsorbed in the intestine, again entering the liver through the portal system. It is excreted in the form of conjugates by the kidneys. The rate of withdrawal directly depends on the physiological state (gestation, phase of the ovarian menstrual cycle), other factors and age.
Release form
As the instructions indicate, "Folliculin" is available in the form of ampoules (oil solution intended for injection). Next, find out what the drug has indications for use.
Indications for use of Folliculin
This medication is prescribed to patients in a number of the following cases:
- Against the background of conditions caused by insufficient ovarian functions.
- If a woman develops primary and secondary amenorrhea.
- The development of genital hypoplasia along with insufficient formation of sexual secondary signs, menopause and postcastration disorders.
- In case of infertility due to a decrease in estrogenic function of the ovaries.
- With a weakness of labor.
- Against the background of a postponed pregnancy.
What is it - dysmenorrhea in women, we will tell below.
This medicine is prescribed to patients intramuscularly.
Application
What else does the instruction for Folliculin tell us? Dosage is set individually. With primary amenorrhea with underdevelopment of the genital organs and against the background of sexual secondary signs, this drug is prescribed 1 or 2 milliliters daily or every other day for one to two months or more (until a noticeable increase in the uterus is achieved). Further, patients are prescribed progesterone (usually intramuscularly, 5 milligrams daily for six to eight days). If necessary, the course of hormone therapy is repeated.
With secondary amenorrhea, 1 milliliter is prescribed daily for fifteen to sixteen days with the subsequent use of progesterone for about eight days. Against the background of the absence of a stable effect, the course of therapy is repeated.
In the case of oligomenorrhea, algodismenorrhea, infertility due to ovarian hypofunction or uterine underdevelopment, injections are given after completion of menstruation, 1 milliliter daily for sixteen days. Further, when indicated, progesterone is prescribed for eight days. The course of therapy can be repeated after the end of menstruation.
For functional disorders caused by the onset of ovariectomy (depression, angioedema, etc.), the drug is prescribed 1 milliliter daily or two days later with courses of fifteen injections. The course of therapy is repeated with the resumption of symptoms. In this case, the dosage should be selected strictly individually (the selection of the minimum effective dosages is required) depending on the stage of the menopause, and in addition, on the severity of the symptoms.
Against the background of weak labor and in the event of a postponed pregnancy, women are prescribed 5 milliliters from the Folliculin ampoule two or three hours before the use of birth control drugs.
Use for menopausal disorders
According to the instructions, the medicine can also be used to treat the pathological manifestation of menopause, which is associated not only with the natural aging of the female body, but also with surgical removal of the ovaries. In this case, after a day, 10,000 units are intramuscularly administered.
For a course of Folliculin therapy for menopausal disorders, usually ten to fifteen injections are prescribed. If the symptoms of pathological menopause occurs again, then therapy can be repeated. At the same time, one must strive to apply the minimum dosage of the drug, which ensure the achievement of a positive effect of the treatment, and it is necessary to take into account the patient's age along with the phase of the menopause, the severity of nervous and cardiovascular disorders.
Dysmenorrhea in women - what is it?
Algomenorrhea (algodismenorea, dysmenorrhea) is a pathological process cyclically repeated on the days of menstruation, due to a complex of metabolic, neurovegetative, behavioral disorders. Translated from the Greek dysmenorrhea means "difficult menstrual flow." A specific sign of dysmenorrhea is pain in the abdomen and pelvis, in rare cases radiating to the legs and sacrum. Severe pain signals a violation of the menstrual cycle, can be supplemented by weakness, dizziness, emotional bursts.
Overdose
If this occurs, the following symptoms may be observed in patients: increased headache along with nausea. And with prolonged use, uterine bleeding is possible. Symptomatic treatment will be required.
Side effects
According to the instructions to "Folliculin," among undesirable reactions, one should be wary of nausea, vomiting, headache, dizziness, allergic manifestations, edema and erythropenia. In case of prolonged use, uterine bleeding is possible along with ovarian sclerosis, impaired metabolism of sodium, water and calcium, and congestive jaundice is not excluded.
Contraindications
Among the contraindications, the following conditions and diseases are worth highlighting:
- The presence of increased sensitivity.
- The presence of neoplasms (whether malignant and benign pathologies) of the mammary glands and genitals among women under the age of sixty years.
- The development of mastopathy.
- The presence of inflammatory diseases of the female genital organs.
- Vaginal or uterine bleeding of unknown etiology.
- The development of a tendency to uterine bleeding.
- Hypestrogenic stage of menopause.
- Liver or kidney failure.
- The development of thrombophlebitis and recurrent thromboembolism in history.
- The presence of pregnancy.
Contraindications "Folliculin" should be strictly observed.
General recommendations for use
Treatment with this drug should be carried out under the supervision of a doctor. With great caution, this medicine is prescribed if the patient has arterial hypertension, a thromboembolic disease, amid epilepsy or depression (including a history), gall bladder ailments and otosclerosis. Before starting therapy with the drug, you must undergo a thorough general gynecological and medical examination, including a full examination of the mammary glands.
Such a diagnosis should be carried out every six months of treatment. In case of acute visual and hearing impairment, thrombosis, if there are signs of phlebitis, stagnation of bile or hepatitis, the use of this medication should be stopped. When carrying in the early postpartum period, the use of the drug "Folliculin" is suspended. During therapy, breastfeeding should be discontinued. In adolescence and childhood (until bone growth is complete), the drug should be used with great care, since there is the possibility of developing a violation of the skeletal system.
Interaction with other medications and with alcohol
It should be borne in mind that this medicine enhances the effects of hypocholesterolemic, antihypertensive and antiarrhythmic drugs, as well as diuretics, tricyclic antidepressants, anticoagulants, glucocorticoids and thyroid hormones.
Exposure to estrogen is enhanced by folic acid and thyroid medications. The concentration of this drug in the blood is lowered by Ampicillin along with Levomycetin, Tetracycline, Neomycin and sulfonamides. But the concentration of the drug in question is increased due to ascorbic acid. Keep this product at a temperature of no more than fifteen degrees.